Concurrent Platform Sessions
SATURDAY, APRIL 6 10:45 am-12:30 pm
Program number is in
bold
above title. The first author is the presenter. Full abstracts can be found online
40
Drosophila Models of Human Diseases
II
Co-Moderators: Ross Cagan, Mount Sinai School of Medicine, New
York and Leo Pallanck, University of Washington, Seattle
Room: Marriott Ballroom Salon 1, Lobby Level
112
- 10:45
Drug screening on a new Drosophila cardiac model of Friedreich
Ataxia.
Veronique Monnier, Hervé Tricoire.
BFA Unit, University
Paris Diderot, 75205 Paris Cedex 13, France.
113
- 11:00
Rescue of insulin signaling misregulation in a fly model of fragile x
syndrome.
Rachel E. Monyak
1
,
Danielle Emerson
1
,
Yan Wang
1
,
Xiangzhong Zheng
2
,
Brian Schoenfeld
3
,
Sean McBride
1
,
Amita
Sehgal
2
,
Thomas Jongens
1
.
1)
Department of Genetics University of
Pennsylvania Perelman School of Medicine Philadelphia, PA; 2)
Howard Hughes Medical Institute and Department of Neuroscience
University of Pennsylvania Perelman School of Medicine Philadelphia,
PA; 3) Section of Molecular Cardiology Departments of Medicine and
Molecular Pharmacology Albert Einstein College of Med Bronx, NY.
114
- 11:15
Sphingosine 1-phosphate mediated suppression of dystrophic muscle
wasting in Drosophila and mice.
Mario Pantoja
1
,
Karin A. Fischer
1
,
Nicholas Ieronimakis
2
,
Timothy L. Dosey
1
,
Junlin Qi
1
,
Aislinn
Hayes
2
,
Morayma Reyes
2,3
,
Hannele Ruohola-Baker
1
.
1)
Dept
Biochem, Univ Washington, Seattle, WA; 2) Dept Pathology; 3) Dept
Labortory Medicine.
115
- 11:30
A kinome-wide RNAi screen in
Drosophila
glia reveals new kinases
that mediate cell proliferation and survival in human
glioblastoma.
Renee Read
1,2
,
Tim Fenton
3
,
German Gomez
3
,
Jill
Wykosky
3
,
Scott Vandenberg
4
,
Ivan Babic
3
,
Akio Iwanami
5
,
Huijun
Yang
3
,
Webster Cavenee
3
,
Paul Mischel
3
,
Frank Furnari
3
,
John
Thomas
2
.
1)
Department of Pharmacology, Emory University School
of Medicine, Atlanta, GA; 2) The Salk Institute for Biological Studies,
Molecular Neurobiology Laboratory, La Jolla, CA; 3) Ludwig Institute
for Cancer Research, University of California - San Diego,; 4)
Department of Pathology, University of California - San Diego, La
Jolla, CA; 5) Department of Orthopaedic Surgery, Keio University
School of Medicine, Tokyo, Japan.
116
- 11:45
Functional characterisation of human synapse genes expressed in
the
Drosophila
brain, applications in drug screening.
Matt B.
Mahoney, Lysimachos Zografos, R. Wayne Davies, J. Douglas
Armstrong.
Brainwave Discovery, LTD, Ardshiel, Main Street,
Gartmore, FK8 3RJ, United Kingdom.
117
- 12:00
Renal proximal tubule receptors Cubilin and Amnionless mediate
protein reabsorption in Drosophila nephrocytes.
Fujian Zhang
1
,
Ying
Zhao
1
,
Yufang Chao
1
,
Katherine Muir
1
,
Zhe Han
1,2
.
1)
Department
of Internal Medicine, University of Michigan, Ann Arbor, MI; 2)
Department of Cell and Developmental Biology.
118
- 12:15
SMN is required for RNA splicing in sensory-motor circuits.
Brian
McCabe
1,2
,
Francesco Lotti
1
,
Erin Beck
1,2
,
Ben Choi
1,2
,
George
Mentis
1
,
Christine Beattie
3
,
Livio Pellizzoni
1
,
Wendy Imlach
1,2
.
1)
Pathology & Cell Biology, Columbia University, New York, NY; 2)
Neuroscience, Columbia University, New York, NY; 3) Neuroscience,
The Ohio State University, Columbus, OH.
Regulation of Gene Expression II
Co-Moderators: Erica Larschan, Brown University, Providence, Rhode
Island and Angelika Stathopoulos, CalTech, Pasadena, California
Room: Marriott Ballroom Salon 2, Lobby Level
119
- 10:45
Widespread and distinct sequence signatures of combinatorial
transcriptional regulation.
M. Kazemian
1
,
H. Pham
2
,
M. Brodsky
2
,
S.
Sinha
1
.
1)
U of Illinois, Urbana, IL; 2) UMASS Med School,
Worcester, MA.
120
- 11:00
Synergistic interactions between MSL complex and the CLAMP
protein regulate Drosophila dosage compensation.
Marcela Soruco
1
,
Jessica Chery
1
,
Eric Bishop
2,7
,
Trevor Siggers
3
,
Michael
Tolstorukov
2,3
,
Alexander Leydon
1
,
Arthur Sugden
1
,
Karen
Goebel
1
,
Jessica Feng
1
,
Peng Xia
1
,
Anastasia Vedenko
3
,
Martha
Bulyk
3,4,5
,
Peter Park
2,3,6
,
Erica Larschan
1
.
1)
Department of
Molecular Biology, Cellular Biology and Biochemistry, Brown
University, Providence, RI ; 2) Center for Biomedical Informatics,
Harvard Medical School, Boston MA; 3) Division of Genetics,
Department of Medicine, Brigham & Women’s Hospital and Harvard
Medical School, Boston, MA ; 4) Department of Pathology, Brigham &
Women’s Hospital and Harvard Medical School, Boston, MA; 5)
Harvard-MIT Division of Health Sciences and Technology, Harvard
Medical School, Boston, MA; 6) Children’s Hospital Informatics
Program, Boston, MA; 7) Bioinformatics Graduate Program, Boston
University,
121
- 11:15
Akirin: a novel link between Twist transcription factor activity and
Brahma chromatin remodeling complexes during embryogenesis.
Scott
J. Nowak
1
,
Hitoshi Aihara
3
,
Katie Gonzalez
2
,
Yutaka Nibu
3
,
Mary
K. Baylies
2
.
1)
Dept. of Biology and Physics, Kennesaw State
University, Kennesaw, GA 30144; 2) Developmental Biology Program,
Sloan-Kettering Institute, New York, NY 10065; 3) Cell and
Developmental Biology, Weill Cornell Medical College, New York,
NY 10065.
122
- 11:30
Zelda's role in
Drosophila
zygotic genome activation.
Yujia Sun
1
,
Sun
Melody Foo
1
,
Chung-Yi Nien
1
,
Hsiao-Yun Liu
1
,
Kai Chen
2
,
Kevin
O'Brien
1
,
Amruta Tamhane
1
,
Julia Zeitlinger
2
,
Christine
Rushlow
1
.
1)
Department of Biology, New York University, New
York, NY 10003; 2) Stowers Institute for Medical Research, 1000 East
50
th Street, Kansas City, MO 64110.
123
- 11:45
Analysis of evolution within the bHLH transcription factor family
based on a complete set of DNA binding interaction
specificities.
Hannah Pham, Jianhong Ou, Scot Wolfe, Michael
Brodsky.
Program in Gene Function and Expression, University of
Massachusetts Medical School, Worcester, MA.
124
- 12:00
Transcription Start Site Turnover in Drosophila using CAGE.
Bradley
J. Main, Hyosik Jang, Andrew Smith, Sergey Nuzhdin.
MCB, Univ
Southern California, Los Angeles, CA.
125
- 12:15
Role of regulatory small peptides in the control of gene
expression.
Francois Payre
1,2
,
Emilie Benrabah
1,2
,
Jennifer Zanet
1,2
,
Serge Plaza
1,2
.
1)
Center for Developmental Biology, University of
Toulouse,Toulouse, France; 2) CNRS, UMR5547, Toulouse France.
