Concurrent Platform Sessions
SATURDAY, APRIL 6 8:30-10:15 am
Program number is in
bold
above title. The first author is the presenter. Full abstracts can be found online
38
Drosophila Models of Human Diseases I
Co-Moderators: Ross Cagan, Mount Sinai School of Medicine, New
York and Leo Pallanck, University of Washington, Seattle
Room: Marriott Ballroom Salon 1, Lobby Level
91
- 8:30
Mannitol - a BBB disrupter is also a potent α-synuclein aggregation
inhibitro for treating Parkinson's disease.
Daniel Segal
1,2
,
Ronit
Shaltiel-Karyo
1
,
Moran Frenkel-Pinter
1
,
Edward Rockenstein
3
,
Christina Patrick
3
,
Michal Levy-Sakin
1
,
Nirit Egoz-Matia
1
,
Eliezer
Masliah
3
,
Ehud Gazit
1
.
1)
Department of Molecular Microbiol &
Biotech, Tel Aviv University, Tel Aviv 69978, Israel; 2) Sagol School
of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel; 3)
Department of Neurosciences, School of Medicine, University of
California at San Diego, La Jolla, CA 92093, USA.
92
- 8:45
Bioinformatics-driven approaches to building new fly models of human
disease.
Stephanie E. Mohr
1
,
Yanhui Hu
1
,
Ian Flockhart
1
,
Juliane
Schneider
2
,
Charles Roesel
1,3
,
Lizabeth Perkins
1
,
Norbert
Perrimon
1,4
.
1)
Dept Gen, Harvard Med Sch, Boston, MA; 2)
Countway Medical Library, Harvard Med Sch, Boston, MA; 3) Grad
Program in Bioinformatics, Northeastern University, Boston, MA; 4)
Howard Hughes Medical Institute, Boston, MA.
93
- 9:00
Early mitochondrial dysfunction leads to oxidative stress in a
drosophila model of TPI deficiency.
Stacy Hrizo
1,2
,
Isaac J. Fisher
1
,
Bartholomew P. Roland
2
,
Daniel R. Long
1
,
Joshua A. Hutton
1
,
Zhaohui Liu
2
,
Michael J. Palladino
2
.
1)
Biology, Slippery Rock
University, Slippery Rock, PA; 2) Pharmacology and Chemical
Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
94
- 9:15
Signaling pathways involved in 1-octen-3-ol mediated neurotoxicity
in
Drosophila melanogaster
:
Implication in Parkinson’s Disease.
Arati
A. Inamdar, Joan W. Bennett.
Department of Plant Biology and
Pathology, Rutgers, The State University of New Jersey, New
Brunswick, NJ.
95
- 9:30
4-
aminoquinoline analogs rescue neurotoxicity in a Drosophila model
of ALS based on TDP-43.
Alyssa Coyne
1
,
Marilyn Roy
2
,
Ivy Lin
2
,
Joel Cassel
4
,
Mark McDonnell
4
,
Allen Reitz
4
,
Daniela
Zarnescu
2,3
.
1)
Department of Neuroscience, University of Arizona,
Tucson, AZ 85721, USA; 2) Department of Molecular and Cellular
Biology, University of Arizona, Tucson, AZ 85721, USA; 3)
Department of Neurology, University of Arizona, Tucson, AZ 85721,
USA; 4) Biopharma, LLC, Pennsylvania Biotechnology Center,
Doyleston, PA 18902, USA.
96
- 9:45
A
Drosophila melanogaster
model identifies a critical role for zinc in
initiating urinary stone formation.
Thomas Chi
1
,
Man Su Kim
2
,
Nichole Bond
1
,
Sven Lang
3
,
Joe Miller
1
,
Gulinuer Muteliefu
3
,
Katja
Bruckner
1
,
Arnie Kahn
3
,
Marshall Stoller
1
,
Pankaj Kapahi
3
.
1)
UCSF, San Francisco, CA; 2) College of Pharmacy, Inje University,
Republic of Korea; 3) Buck Institute for Research on Aging, Novato,
CA.
97
- 10:00
Inhibition of JNK/dFOXO pathway and caspases rescues neurological
impairments in
Drosophila
Alzheimer’s disease model.
Se Min Bang,
Yoon Ki Hong, Soojin Lee, Kyoung Sang Cho.
Biological sciences,
Kunkok university, Seoul, Seoul, South Korea.
Regulation of Gene Expression I
Co-Moderators: Erica Larschan, Brown University, Providence, Rhode
Island and Angela Stathopoulos, CalTech, Pasadena, California
Room: Marriott Ballroom Salon 2, Lobby Level
98
- 8:30
Expression pattern analysis of 6,300 genomic fragments for
cis-
regulatory activity in the imaginal discs of
Drosophila
Melanogater
.
Aurélie Jory
1
,
Carlos Estella
1,3
,
Matt W. Giorgianni
1,4
,
Matthew Slattery
1,5
,
Todd R. Laverty
2
,
Gerald M. Rubin
2
,
Richard
S. Mann
1
.
1)
Department of Biochemistry and Molecular Biophysics,
Columbia University Medical Center, 701 W. 168th Street, HHSC
1104,
New York, NY 10032, USA; 2) Janelia Farms Research Campus,
19700
Helix Drive, Ashburn, VA 20147, USA; 3) Present address:
Departamento de Biología Molecular, and Centro de Biología
Molecular ‘‘Severo Ochoa,’’ Universidad Autónoma de Madrid,
Madrid, Spain; 4) Present address: R.M. Bock Laboratories, University
of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA;
5)
Present address: Institute for Genomics and Systems Biology,
University of Chicago, 900 E. 57th St. KCBD 10115, Chicago, IL
60637,
USA.
99
- 8:45
DNA regulatory element usage is driven largely by developmental
stage, even within distinct cell lineages.
Daniel J. McKay
1
,
Jason D.
Lieb
1,2
.
1)
Department of Biology, The University of North Carolina at
Chapel Hill, Chapel Hill, NC; 2) Carolina Center for Genome
Sciences.
100
- 9:00
Differential regulation of
sloppy-paired-1
transcription initiation and
elongation by Runt and Even-skipped during Drosophila
segmentation.
Kimberly Bell
1,3
,
Saiyu Hang
2,3
,
J. Peter Gergen
3
.
1)
Graduate Program in Genetics; 2) Graduate Program in Biochemistry
and Structural Biology; 3) Department of Biochemistry and Cell
Biology and the Center for Developmental Genetics Stony Brook
University, Stony Brook, NY 11794-5215.
101
- 9:15
Robust Hox-Mediated Transcriptional Regulation Utilizes a
Combination of Flexible Binding Site Composition and Rigid
Grammar.
Juli Uhl, Lisa Gutzwiller, Arif Ghasletwala, Brian
Gebelein.
Developmental Biology, Cincinnati Children's Hospital,
Cincinnati, OH.
102
- 9:30
Autoregulation controls temporal progression of gene expression during
development.
Leslie A. Dunipace, Angelike Stathopoulos.
Biology,
California Institute of Technology, Pasadena, CA.
103
- 9:45
Tissue-specificity of Drosophila Developmental Gene Regulatory
Networks.
Matthew Slattery
1
,
Roumen Voutev
2
,
Rebecca Spokony
1
,
Lijia Ma
1
,
Richard Mann
2
,
Kevin White
1
.
1)
Institute for Genomics
and Systems Biology, University of Chicago, Chicago, IL; 2)
Department of Biochemistry and Molecular Biophysics, Columbia
University, New York, NY.
104
- 10:00
Regulation of
rhodopsins
:
Single nucleotides are critical for
photoreceptor subtype-specific expression.
Jens Rister, Claude
Desplan.
New York University, Department of Biology, 100
Washington Square East, New York, NY.
