Poster Session Listing

Gametogenesis and Organogenesis

157A
MicroRNA-190 downregulates Bag of marbles to allow the switch from proliferation to differentiation in the Drosophila male germline stem cell lineage. Gonzalo H. Olivares, Margaret T. Fuller. Developmental Biology, Stanford University School of Medicine, Palo Alto, CA.

158B
Microtubule (MT)-dependent regulation of muscle length. Victoria K. Schulman^1,2, Eric S. Folker², Mary K. Baylies^1,2. 1) Weill Cornell Graduate School of Medical Sciences, New York, NY; 2) Sloan-Kettering Institute, New York, NY.

159C
Frazzled/DCC facilitates cardiac cell outgrowth and attachment during dorsal vessel formation. Frank D. Macabenta^1,2, Amber G. Jensen^1,2, Yi-Shan Cheng¹, Joseph J. Kramer¹, Sunita G. Kramer^1,2. 1) Pathology Department, UMDNJ/RWJMS, Piscataway, NJ; 2) Cell and Developmental Biology, Rutgers University, Piscataway, NJ.

160A
The core complex of cuticle dynamics in Drosophila exoskeleton. Matthias Behr, Kapil R. Patil, Yanina Y. Pesch, Dominik Hölper. Life & Medical Sciences (LIMES) Institute, Carl-Troll-Str. 31, 53115 Bonn, Germany.

161B
MIPP1 functions at the basolateral domain to facilitate the generation of filopodia and the extension of lamellopodia of tracheal leading cells. Yim Ling Cheng, Deborah Andrew. Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.

162C
The PDZ domain protein Arc is required for proper invagination of the embryonic salivary glands. Rika Maruyama^1,2, Sarah Hughes¹, Deborah Andrew². 1) Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada; 2) Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD.

163A
The large Maf factor Traffic jam functions to repress hub cell fate in the developing germline stem cell niche. Lindsey Wingert, Steve DiNardo. Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA.

164B
Machine learning-based functional characterization of heart enhancers uncovers novel cardiogenic roles for the transcription factors Myb and Su(H). Shaad M. Ahmad^1,4, Brian W. Busser^1,4, Di Huang^2,4, Elizabeth J. Cozart¹, Anton Aboukhalil³, Sebastien Michaud³, Neal Jeffries¹, Martha L. Bulyk³, Ivan Ovcharenko², Alan M. Michelson¹. 1) NHLBI, NIH, Bethesda, MD; 2) NLM, NIH, Bethesda, MD; 3) Harvard Medical School, Boston, MA; 4) Equally contributing first authors.

165C
Investigating the potential non-cell autonomous Robo2 function during lumen formation of the Drosophila melanogaster dorsal vessel. Judith J. Canabal Alvear^1,2, Sunita G. Kramer^1,2. 1) Pathology Department , UMDNJ/RWJMS, Piscataway , NJ; 2) Cell and Developmental Biology, Rutgers University, Piscataway, NJ.

166A
Identification of transcription factors and chromatin regulators with novel roles in muscle morphogenesis. Krista C. Dobi¹, Marc S. Halfon², Mary K. Baylies¹. 1) Dept Dev Biol, Sloan-Kettering Inst, New York, NY; 2) Biochem Dept, SUNY Buffalo, Buffalo, NY.

167B
Cellular mechanisms of heart morphogenesis and lumen formation in Drosophila. Georg Vogler¹, Jiandong Liu², Timothy W. Iafe³, Rolf Bodmer¹. 1) Development and Aging, Sanford Burnham Medical Research Institute, La Jolla, CA; 2) University of North Carolina, School of Medicine, Chapel Hill, NC; 3) New York University, School of Medicine, New York, NY.

168C
Elucidating the role of the nuclear hormone receptor E78 in Drosophila oogenesis. Elizabeth T. Ables^1,2, Kelly E. Bois², Daniela Drummond-Barbosa². 1) Dept. of Biology, East Carolina University, Greenville, NC; 2) Dept. of Biochemistry and Molecular Biology, Johns Hopkins University School of Public Health, Baltimore, MD.

169A
RTC1, a conserved SEA complex component, is required for early oogenesis in Drosophila. Weili Cai, Mary Lilly. NICHD, National Institute of Health, Besthesda, MD.

170B
Aging Related Oogenesis Defects of Upd3 Mutants. Michelle Giedt¹, Liqun Wang², Travis Sexton³, Claire Venard¹, Douglas Harrison¹. 1) Biology Department, University of Kentucky, Lexington, KY; 2) Department of Pathology, Brigham & Woman's Hospital, Harvard Medical School, Harvard New Research Building, Room 652, 77 Avenue Louis Pasteur, Boston, MA; 3) University of Kentucky College of Medicine, Cardiovascular Research Center, 741 S. Limestone St., Lexington, KY.

171C
Selective replication of functional mtDNA during oogenesis restricts the transmission of a deleterious mutation. Jahda H. Hill, Hong Xu. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

172A
FGF mutants exhibit pleiotropic ovariole phenotypes relating to loss of epithelial sheath. Jihyun Irizarry^1,2, Angelike Stathopoulos¹. 1) California Institute of Technology, Division of Biology, Pasadena, CA; 2) CIRM Bridges to Stem Cell Research Program, California State Los Angeles, Los Angeles, CA.

173B
The Mitochondrial Protein Cytochrome c heme lyase is Necessary for Cell Polarity. Sarah E. Kleinsorge, Caryn Navarro. Graduate Program in Genetics and Genomics, BUSM, Boston, MA.

174C
Translational regulation at the oocyte to embryo transition in Drosophila. Iva Kronja¹, Bingbing Yuan¹, Kristina Dzeyk², Joanna Kirkpatrick², Jeroen Krijgsveld², Terry Orr-Weaver¹. 1) Whitehead Institute, MIT, Cambridge, MA; 2) EMBL, Heidelberg, Germany.

175A
Heterologous Segregations are established prior to chromosome congression in female meiosis I in Drosophila melanogaster.. Fiona M. Lane, Ashley A. Snouffer, William D. Gilliland. Biological Sciences Department, DePaul University, Chicago, IL.

176B
asteroid is required for oocyte determination in Drosophila. Julie A. Merkle, Trudi Schüpbach. Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ.

177C
The DExH box helicase region of Spindle-E is necessary for retrotransposon silencing and germline development. Caryn Navarro, Kristen Ott, Tram Nyguyen. Boston University School of Medicine, Boston, MA.

178A
Three-dimensional epithelial morphogenesis in developing eggshells. Miriam Osterfield¹, XinXin Du¹, Trudi Schüpbach^1,2, Eric Wieschaus^1,2, Stanislav Shvartsman¹. 1) Princeton University, Princeton, NJ; 2) Howard Hughes Medical Institute, Princeton, NJ.

179B
Genetic and cytological dissection of mechanisms controlling mitochondrial DNA inheritance in Drosophila melanogaster. Jennifer Leigh Page, Patrick O'Farrell. BIOCHEMISTRY AND BIOPHYSICS, UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA.

180C
Mio: Connecting Meiotic Progression to Metabolism in Early Oogenesis. John C. Reich, Mary Lilly. CBMP, NICHD, Bethesda, MD.

181A
A Role for Prolyl-4-Hydroxylase Alpha in Cell Migration During Oogenesis. Jinal S. Sheth, Michelle Starz-Gaiano. Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD.

182B
Genes that act to destroy mitochondrial DNA in spermatids and enforce maternal only inheritance. Steven Z. DeLuca, Patrick H. O'Farrell. Dept. of Biochemistry, UCSF, San Francisco, CA.

183C
Identifying new regulators of secretory capacity. Rebecca M. Fox, Xueni Chen, Deborah J. Andrew. Dept Cell Biol, Johns Hopkins Univ, Baltimore, MD.

184A
Terminal cells lacking V-ATPase appear to form auto-cellular rather than seamless tubes. Deanne M. Francis, Amin Ghabrial. Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA.

185B
Role of expansion in Drosophila tracheal tube diameter regulation. Ekaterini Iordanou, Rachana R. Chandran, Mina Essak, Lan Jiang. Biological Sciences, Oakland University, Rochester, MI.

186C
Myogenesis of the smooth muscles surrounding the testes of Drosophila melanogaster males. Jessica Kuckwa¹, Christina Hornbruch-Freitag¹, Loreen Susic-Jung¹, Uwe Lammel², Renate Renkawitz-Pohl¹. 1) Developmental Biology, University of Marburg, 35043, Marburg, Germany; 2) Neurobiology, University of Muenster, 48149, Muenster, Germany.

187A
Identification of somatic factors controlling ovarian development by RNAi screening. Chun-Ming Lai^1,2, Yueh Cho¹, Hwei-Jan Hsu¹. 1) Inst Cellular & Organismic Biol, Academia Sinica, Taipei, Taipei, Taiwan; 2) Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, National Chung-Hsing University and Academia Sinica, Taipei, Taiwan.

188B
Analysis of Neprilysins 1-5 in Drosophila melanogaster reveals parallels between mammalian and invertebrate roles in reproductive fitness. J. Sitnik³, C. Francis^1,2, R. Huybrechts⁴, M. Wolfner³, P. Callaerts^1,2. 1) Laboratory of Behavioral and Developmental Genetics, KULeuven, Leuven, Belgium; 2) VIB Center for the Biology of Disease, Leuven, Belgium; 3) Dept. of Molecular Biology and Genetics, Cornell University, Ithaca NY, USA; 4) Zoological Institute, KULeuven, Leuven, Belgium.

189C
The H4K16 histone acetyltransferase chameau is a putative target of Doublesex. Emily Clough¹, Cale Whitworth², Erin Jimenez², Hania Pavlou³, Megan Neville³, Stephen Goodwin³, Mark Van Doren², Brian Oliver¹. 1) Laboratory of Cellular and Developmental Biology, NIDDK/NIH, Bethesda , MD; 2) Department of Biology, Johns Hopkins University, Baltimore, MD; 3) Department of Physiology, Anatomy and Genetics,University of Oxford, Oxford, UK.

190A
A Genomic Analysis of Sex Determination. Erin Jimenez¹, Cale Whitworth¹, Emily Clough², Brian Oliver², Mark Van Doren¹. 1) Biology, Johns Hopkins University, Baltimore, MD; 2) NIDDK, National Institutes of Health, Bethesda, MD.

191B
Female-expressed genes that affect the post mating response in Drosophila melanogaster. Alexandra L. Mattei, Jessica L. Sitnik, Frank W. Avila, Amber R. Krauchunas, Mariana F. Wolfner. Cornell University, Ithaca, NY.

192C
Genetic basis for developmental homeostasis of germline stem cell niche number: a network of Tramtrack-group nuclear BTB factors. Mathieu Bartoletti^1,2,3, Thomas Rubin^2,3, Fabienne Chalvet^2,3,4, Sophie Netter^1,2,3, Nicolas Dos Santos^2,3, Emilie Poisot^2,3, Melanie Paces-Fessy^2,3,5, Delphine Cumenal⁵, Frederique Peronnet⁵, Anne-Marie Pret^1,2, Laurent Theodore^1,2,4. 1) Centre de Génétique Moléculaire - UPR 3404, GIF SUR YVETTE, France; 2) Departement de Biologie, Univ Versailles St-Quentin, Versailles, France; 3) Laboratoire de Génétique et Biologie Cellulaire, Equipe Associée 4589, Univ Versailles St-Quentin, Versailles , France; 4) Departement de Biologie, Univ Paris-Sud, Orsay, France; 5) Biologie du Développement UMR 7622, CNRS et UPMC, France.

193A
Apontic acts as a JAK/STAT pathway regulator in the Drosophila testis niche. Kathryn A. Bus, Archana Murali, Michelle Starz-Gaiano. University of Maryland Baltimore County, Batimore, MD.

194B
The Role of miR-310s in Regulation of Somatic Cell Differentiation in Drosophila Ovary. Omer Cicek, Halyna Shcherbata. MPRG of Gene Expression and Signaling, Max Planck Institute, Goettingen, Germany.

195C
Putative sperm chromatin condensing proteins and their respective conserved domains in 12 sequenced species of Drosophila. Zain A. Alvi, Tin-Chun Chu, Angela V. Klaus. Department of Biological Sciences, Seton Hall University, South Orange, NJ.

196A
Lipid signaling between soma and germline is required for Drosophila spermatogenesis. Geulah Ben-David, Josefa Steinhauer. Department of Biology, Yeshiva College, New York, NY.

197B
Studying the effects of Hsp27 phosphorylation on viability and fertility. Emily Furbee¹, Joseph Ayoob², Jonathan Minden¹. 1) Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA; 2) Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

198C
The role of Tudor-SN in spermatogenesis and the Piwi-piRNA pathway. Hsueh-Yen Ku, Vamsi Gangaraju, Haifan Lin. Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT.

199A
Characterizing the genetic basis for mitochondrial shaping defects in emmenthal mutants of Drosophila melanogaster. Will S. Mitchell, Karen G. Hales. Department of Biology, Davidson College, Davidson, NC.

200B
Roles for testis-enriched ATP synthase subunits in mitochondrial shaping during Drosophila spermatogenesis. Eric M. Sawyer, Olivia Brown, Yihharn Hwang, Lauren Ivey, Kelsey E. Sheaffer, Conroy Field, Taylor Gunnell, Karen G. Hales. Department of Biology, Davidson College, Davidson, NC.

Cell Biology & Signal Transduction

201C
Cooperation of Mad and Akt signaling in a Drosophila model of epithelial plasticity. Courtney Onodera^4,8, Björn Gärtner^5,8, Samantha Aguinaldo-Wetterholm^2,9, David Casso^2,9, J. Alex Rondon^2,6,9, Samuel Meier⁵, Aiguo Tian^2,7, Brandy Alexander², Rik Derynck^1,2,3, Jun S. Song^1,4, Julia Zeitlinger⁵, Katja Brückner^1,2,3. 1) Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research; 2) Department of Cell and Tissue Biology; 3) Department of Anatomy; 4) Institute for Human Genetics, University of California San Francisco, San Francisco, CA; 5) Stowers Institute for Medical Research, Kansas City, MO; 6) present address: Genentech; 7) present address: UT Southwestern; 8) equal contribution; 9) equal contribution.

202A
The Drosophila BMPRII, Wishful thinking, is required for eggshell patterning. Rob Marmion¹, Milica Jevtic², George Pyrowolakis², Nir Yakoby¹. 1) Department of Biology and Center for Computational and Integrative Biology, Rutgers University, Camden, NJ; 2) Institute for Biology I, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

203B
A Novel Role for UDP-GlcNAC in Dpp Signal Antagonism. Matthew J. Moulton, Gregory Humphreys, Anthea Letsou. Human Genetics, University of Utah, Salt Lake City, UT.

204C
GPI-mannosyltransferase 2 shapes the Hedgehog morphogen gradient. Yi-Nan Lee¹, Haiwei Pi², Cheng-Ting Chien¹. 1) Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan; 2) Department of Biomedical Sciences, Chang-Gang University, Taoyuan 333, Taiwan.

205A
Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and Shifted/dWif. David Sánchez Hernández, Aphrodite Bilioni, Ainhoa Callejo, Ana-Citlali Gradilla, Carmen Ibañez, Emanuela Mollica, M.Carmen Rodríguez-Navas, Eleanor Simon, Isabel Guerrero. CBMSO, Madrid, Madrid, Spain.

206B
The interactions among upd-family ligands. Qian Chen, Douglas Harrison. Dept Biol, Univ Kentucky, Lexington, KY.

207C
A novel calcyphosine-like protein facilitates border cell migration during oogenesis. Lathiena A. Manning, Michelle Starz-Gaiano. Biological Sciences, University of Maryland Baltimore County, Baltimore, MD.

208A
An in vivo RNAi screen identifies components of the JAK/STAT signaling that regulate cell migration. Afsoon Saadin, Michelle Starz-Gaiano. Biological Sciences, UMBC, Baltimore, MD.

209B
JAK/STAT pathway plays two opposite roles in Drosophila spermatogenesis. Lingfeng Tang, Douglas Harrison. Department of Biology, University of Kentucky, Lexington, KY.

210C
Drosophila glypican Dally regulates Upd distribution and JAK/STAT signaling activity in eye development. Jia You¹, Yan Zhang², Wenyan Ren², Xinhua Lin^1,2. 1) Dev Biol, Cincinnati Chld Hosp Med Ctr, Cincinnati, Oh; 2) 1State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

211A
Spatial and temporal analysis of axonal transport in primary neuronal cultures from Drosophila larvae. Gary Iacobucci, Noura Abdel Rahman, Aida Andrades Valtueña, Shermali Gunawardena. Biological Sciences, State University of New York at Buffalo, Buffalo, NY.

212B
Drosophila Tempura, a novel Rab geranylgeranyl transferase subunit, modulates Notch signaling via Rab1 and Rab11. Wu-Lin Charng¹, Shinya Yamamoto^1,2, Manish Jaiswal^2,6, Vafa Bayat^1,3, Bo Xiong¹, Ke Zhang⁴, Hector Sandoval², Gabriela David¹, Hsiang-Chih Lu¹, Kuchuan Chen¹, Hugo Bellen^1,2,4,5,6. 1) Program in Developmental Biology; 2) Dept of Molecular and Human Genetics; 3) Medical Scientist Training Program; 4) Program in SCBMB; 5) Dept of Neuroscience; 6) Howard Hughes Medical Institute; The Neurological Research Institute; Baylor College of Medicine, Houston, TX.

213C
Identification of novel maternal neurogenic genes that are potential components of Notch signaling in Drosophila. Takuma Gushiken^1,2, Kenjiroo Matsumoto^1,2, Takahiro Seto², Ryo Hatori^1,2, Shunsuke Shimaoka^1,2, Tomoko Yamakawa¹, Takeshi Sasamura¹, Kenji Matsuno¹. 1) Department of Biological Science, Osaka university, Japan; 2) Department of Biological Science and Technology, Tokyo University of Science, Japan.

214A
Direct regulation of broad expression by Notch signaling during the mitotic/endocycle switch in Drosophila follicle cells. Dongyu Jia¹, Yoichiro Tamori¹, George Pyrowolakis^2,3, Wu-Min Deng¹. 1) Department of Biological Science, Florida State University, Tallahassee, FL 32306. USA; 2) Institute for Biology I, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Hauptstrasse 1, 79104 Freiburg, Germany; 3) BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany.

215B
Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila. Kenjiroo Matsumoto¹, Tomonori Ayukawa², Ishikawa O. Hiroyuki³, Akira Ishio¹, Tomoko Yamakawa¹, Takuya Suzuki¹, Kenji Matsuno¹. 1) Biological Science, Osaka university, Toyonaka,Osaka, Japan; 2) Medical Science, Akita university, Toyonaka,Akita, Japan; 3) Science, Chiba university, Chiba,Chiba, Japan.

216C
The Drosophila CREB binding protein gene nejire is involved in multiple signaling and cell migration processes in follicle cells. Zhiqiang Shu, Dongyu Jia, Wu-Min Deng. Biological Science, Florida State University, Tallahassee, FL.

217A
Identification of me31B from an in vivo RNAi screen as a potential regulator of Notch Signaling. Muhammed Soylemez, Dongyu Jia, Wu-Min Deng. Department of Biological Science, Florida State University, Tallahassee, FL. Muhammed Soylemez, Dongyu Jia, Wu Min Deng. BIOLOGICAL SCIENCE , FLORIDA STATE UNIVERSITY, TALLAHASSEE , FL.

218B
E(y)1, a component of the transcription initiation complex, is required for Notch signaling activation in Drosophila. Gengqiang Xie, Dongyu Jia, Wu-Min Deng. Department of Biological Science, Florida State University, Tallahassee, FL, 32306.

219C
Drosophila pecanex activates Notch signaling via unfolded protein response (UPR). Tomoko Yamakawa¹, Yu Atsumi¹, Takeshi Sasamura¹, Naotaka Nakazawa¹, Emiko Suzuki², Mark E. Fortini³, Kenji Matsuno¹. 1) Osaka Univ, Osaka, Japan; 2) Gene Network Lab, NIG, Japan; 3) Thomas Jefferson Univ, Philadelphia, USA.

220A
UIF, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. Hongtao Zhang^1,2, Gengqiang Xie^1,4, Jun Ma^1,3, Renjie Jiao¹. 1) State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, the Chinese Academy of Sciences, Beijing, China; 2) Graduate School of the Chinese Academy of Sciences, Beijing, China; 3) Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children’s Research Foundation, Cincinnati, OH, USA; 4) Department of Biological Science, The Florida State University,Tallahassee, FL 32306, USA.

221B
Interaction between juvenile hormone and insulin/IGF-like signaling mediates lipid homeostasis during lactation in the tsetse fly, Glossina morsitans. Aaron A. Baumann¹, Joshua B. Benoit², Veronika Michalkova², Paul Mireji³, Geoffrey M. Attardo², John K. Moulton⁴, Thomas G. Wilson⁵, Serap Aksoy². 1) HHMI Janelia Farm Research Campus, Ashburn, VA; 2) School of Public Health, Yale University, New Haven, CT; 3) Department of Biochemistry and Molecular Biology, Egerton University, Njoro, Kenya; 4) Department of Entomology and Plant Pathology, University of Tennessee, Knoxville TN; 5) Department of Evolution, Ecology, and Organismal Biology, Ohio State University, Columbus, OH.

222C
The Male Accessory Gland: A novel model to evaluate new ER stress genes. Clement Y. Chow, Andrew G. Clark, Mariana F. Wolfner. Dept Molec Biol & Gen, Cornell Univ, Ithaca, NY.

223A
Phosphatidylinositol Synthase regulates the polarized deposition of basement membrane components. Olivier Devergne, Trudi Schüpbach. Department of Molecular Biology, HHMI/Princeton University , Princeton, NJ.

224B
Characterization of cytoplasmic Eyes absent function in Drosophila eye development. Charlene Hoi, Wenjun Xiong, Fangfang Jiang, Ilaria Rebay. University of Chicago, Chicago, IL.

225C
Vesicle trafficking during wing margin development: a role for Docked. Suresh K. Kandasamy, Justin Thackeray. Biology Dept, Clark University, Worcester, MA.

226A
Phosphoproteomic analysis of Drosophila embryos deficient in neural-specific glycosylation. Varshika Kotu^1,2, Peng Zhao^1,3, Toshihiko Katoh¹, Lance Wells^1,2,3, Michael Tiemeyer^1,2. 1) The Complex Carbohydrate Research Center, University of Georgia, Athens, GA; 2) The Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA; 3) The Department of Chemistry, University of Georgia, Athens, GA.

227B
Dynamic feedback shapes steroid pulses in Drosophila. Morten E. Møller¹, E. Thomas Danielsen¹, Rachel Harder², Michael B. O’Conner², Kim F. Rewitz¹. 1) Department of Biology, University of Copenhagen, Copenhagen, Denmark; 2) Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota.

228C
Negative Regulation of the Folded gastrulation Signaling Pathway by the Non-visual β-arrestin Kurtz. Emily J. Simon, Alyssa J. Manning, Stephen L. Rogers. Dept Biology, Univ North Carolina-Chapel Hill, Chapel Hill, NC.

229A
Mechanism and function of the capa/capaR in the desiccation stress response in Drosophila. Selim Terhzaz, Pablo Cabrero, Louise Henderson, Julian A. T. Dow, Shireen-A. Davies. Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom.

230B
Chmp1 may negatively regulate DER and Notch signaling. Meagan Valentine, Simon Collier. Dept Biomedical Sciences, Marshall University, Huntington, WV.

231C
The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2. Samantha J. Warrington, David Strutt. University of Sheffield, Sheffield, United Kingdom.

232A
Nicotinamide Mononucleotide Adenylyltransferase (NMNAT) Maintains Active Zone Structure by Stabilizing Bruchpilot. Shaoyun Zang¹, Yousuf O. Ali², Ruan Kai¹, R. Grace Zhai¹. 1) University of Miami,1600 NW 10 Ave. R.M.S.B. Bldg. 6068, Miami, FL 33136; 2) Baylor College of Medicine, Jan and Dan Duncan Neurology Institute, 1250 Moursund, Houston TX 77025.

233B
Regulation of cell migration during dorsal appendage morphogenesis. Sandra G. Zimmerman, Celeste A. Berg. Department of Gemone Sciences, University of Washington, Seattle, WA.

234C
Role of Dachs localization and ATPase activity in Fat signaling. Abhijit A. Ambegaonkar, Cordelia Rauskolb, Kenneth Irvine. Waksman Institute of Microbiology, Rutgers, the State University of New Jersey, Piscataway, NJ.

235A
The transcriptional TOR and AMPK target sugarbabe regulates amino acid and lipid catabolism. Torsten Buelow, Katrin Riemschoss, Ingo Zinke, Michael J. Pankratz. Molecular Brain Physiology and Behavior, LIMES Institute, University of Bonn, 53115 Bonn, Germany.

236B
Investigating the Role of PI4P in Lysosome-related Organelle Biogenesis in the Drosophila Eye. Lauren M. Del Bel^1,2, Ronit Wilk¹, Jason Burgess^1,2, Gordon Polevoy¹, Ho-Chun Wei¹, Julie Brill^1,2. 1) Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada; 2) Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

237C
Investigating Expanded localization and binding partners. Leonie Alexandra Enderle, Robyn Rosenfeld, Vladimir Belozerov, Helen McNeill. Research, SLRI, Toronto, Ontario, Canada.

238A
Endocytotic vacuolation and vacuole acidification act in concert during early-to-mid prepupal development of Drosophila salivary glands. Robert Farkas¹, Denisa Benova-Liszekova¹, Zuzana Datkova^1,2, Daniel Vlcek², Milan Beno^1,2, Ludmila Pecenova^1,2, Otakar Raska³, Pavel Juda³, Lubos Kovacik³, Ivan Raska³, Bernard Mechler^3,4. 1) Inst Experimental Endocrinology, Slovak Academy Sciences, Vlarska 3, 83306 Bratislava, Slovakia; 2) Department of Genetics, Faculty of Science, Comenius University, Bratislava, Slovakia; 3) Institute of Cellular Biology and Pathology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 4) Department of Developmental Genetics, Deutsches Krebsforschungszentrum-ZMBH Allianz, Heidelberg, Germany.

239B
The interplay between TNF signaling, apoptosis, and tissue damage-induced pain sensitization in Drosophila larvae. Juyeon Jo¹, Felona Gunawan², Daniel Babcock¹, Michael Galko¹. 1) UT M.D. Anderson cancer center, Housotn, TX; 2) Rice University.

240C
JNK Signaling Antagonism: The role of Raw during Drosophila dorsal closure. Molly C. Jud, Melissa Ratcliffe, Anthea Letsou. Human Genetics, University of Utah, Salt Lake City, UT.

241A
Lipid modification of secreted signaling proteins. Hui Hua Liu¹, Rayshonda Hardy², Steven Blais¹, Thomas Neubert¹, Marilyn Resh², Jessica Treisman¹. 1) Kimmel Center for Biology and Medicine of the Skirball Institute, NYU School of Medicine, New York, NY; 2) Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY.

242B
Spargel/ PGC-1 is the new terminal effector in the Insulin-Tor Signaling pathway. Subhas Mukherjee, Atanu Duttaroy. Biology, Howard University, Washington, DC.

243C
Acal, a new ‘vessel’ that negatively regulates JNK signaling. Luis Daniel Ríos-Barrera, Juan Rafael Riesgo-Escovar. Developmental Neurobiology Dept., Neurobiology Institute, Universidad Nacional Autónoma de México, Queretaro, Mexico.

244A
The atypical cadherin Fat directly regulates mitochondrial function to control planar cell polarity and Hippo signaling. Anson D. Sing^1,2, Yonit Tzatzkis², Maïlis Bietenhader³, Lacramioara Fabian⁴, Tasha Stoltz³, Robyn Rosenfeld^1,2, Julie A. Brill^1,4, G. Angus McQuibban³, Helen McNeill^1,2. 1) Molecular Genetics, University of Toronto, Toronto, ON, Canada; 2) Samual Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; 3) Department of Biochemistry, University of Toronto, Toronto, ON, Canada; 4) Collaborative Program in Developmental Biology, Hospital for Sick Children, Toronto, ON Canada.

245B
Control of lipid metabolism by gut Tachykinin hormones. Wei Song¹, Jan Veenstra³, Norbert Perrimon^1,2. 1) Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; 2) Howard Hughes Medical Institute; 3) Université de Bordeaux, INCIA UMR 5287 CNRS, 33405 Talence, France.

246C
Dissecting the Fat/Dachsous pathway’s role in planar cell polarity using chromatin immunoprecipitation to find targets of Atrophin. Kelvin Yeung^1,2, Helen McNeill^1,2. 1) Research, Samuel Lunenfeld Res Inst, Toronto, Ontario, Canada; 2) Molecular Genetics, University of Toronto St. George Campus, Toronto, Ontario, Canada.

247A
The effect adenosine receptor and adenosine transporter on energy homeostasis. Michal Zurovec, Roman Sidorov, Lucie Kucerova. Dept Physiology, Biology Centre, Inst Entomology, Ceske Budejovic, Czech Republic.

248B
Investigation of novel epidermal growth factor receptor target genes implicated in Drosophila egg and wing development. Jacquelyn Gallo, Luke Dombert, Justin Hunter, Kristopher Krawchuk, Connor Zale, Lisa Kadlec. Department of Biology, Wilkes University, Wilkes-Barre, PA.

249C
Torso-like influences developmental timing in Drosophila melanogaster independently of the Torso RTK pathway. Travis K. Johnson^1,2, Tova Crossman², Karyn Foote², Michelle A. Bennett², Lauren Forbes Beadle², Anabel Herr^1,2, James C. Whisstock¹, Coral G. Warr². 1) Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia; 2) School of Biological Sciences, Monash University, Clayton, Victoria, 3800, Australia.

250A
Friend of Echinoid (Fred) and Echinoid (Ed) regulate EGFR trafficking. Qian Nie, Susan Spencer. Department of Biology, Saint Louis, MO.

251B
Characterization of Dis3 in Drosophila melanogaster. Amanda Raimer¹, Mark Snee², Hemlata Mistry¹, James Skeath². 1) Department of Biochemistry, Widener University, Chester, PA; 2) Department of Genetics, Washington University School of Medicine, St. Louis, MO.

252C
Importance of tyrosine phosphorylation for Echinoid’s function. Peter P. Saengthien, Erin J. Andrews, Susan A. Spencer. Saint Louis University, St. Louis, MO.

253A
Motor neuron regulates Indirect muscle patterning through EGF ligands. Kumar Vishal, Lindsay Grainger, Mary Turvy, Joyce Fernandes. Dept Zoology, Maimi Univ, Oxford, OH.

254B
RhoGAP68F regulates endocytic recycling to facilitate epithelial flattening and tissue elongation. Beatriz Hernandez de Madrid, Lina Greenberg, Victor Hatini. Anatomy and Cell Biology, Tufts University, Boston, MA.

255C
In vivo Time Lapse Confocal Analysis of the RhoA Head Involution Defect and Molecular and Genetic Characterization of Five Extant RhoA Mutant Alleles. Melissa Maloof¹, Rachel Stottlar¹, Pria Chang¹, Laura Johansen¹, Katherine Sinclair¹, Maureen Filak¹, Fafa H. Koudoro¹, Rahul Warrior², Susan R. Halsell¹. 1) Biology, James Madison University, Harrisonburg, VA; 2) Developmental and Cell Biology, University of California, Irvine, CA.

256A
Ack1 regulates a macromolecular complex involved in nucleotide synthesis. Todd Strochlic, Alana O'Reilly, Jeffrey Peterson. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA.

257B
Wnt/Wingless signaling, Earthbound, and Erect Wing are required for late stages of indirect flight muscle development. Hassina Benchabane, Ai Tian, Yashi Ahmed. Department of Genetics, Geisel School of Medicine at Dartmouth.

258C
TH8, a new ADAMTS like protease in Wg signaling pathway. Go-Woon Kim, Jong-Hoon Won, Ok-Kyung Lee, Orkhon Tsogtbaatar, Su-Jin Nam, Yeon Kim, Kyung-Ok Cho. Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.

259A
Revisiting the role of Wnt signaling in sensory organ development in the Drosophila wing. Ezgi Kunttas-Tatli, Kellie Kravarik, Sandra Zimmerman, Amy Fuller, Brooke M. McCartney. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA.

260B
An in vivo kinome and phosphatome RNAi screen in the Drosophila wing imaginal disc identifies a novel regulator of Wnt/Wg secretion. Tirthadipa Pradhan, Sharan Swarup, Esther Verheyen. Simon Fraser Unversity, Burnaby, Canada.

261C
Regulation of Wnt signaling by the tumor suppressor APC does not require the ability to enter the nucleus nor a particular cytoplasmic localization. David M. Roberts¹, Mira I. Pronobis², John S. Poulton², Eric G. Kane¹, Mark Peifer². 1) Department of Biology, Franklin & Marshall College, Lancaster, PA; 2) Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

262A
The interaction between Tankyrase and Axin modulates Wingless signaling during development. Ofelia Tacchelly Benites, Zhenghan Wang, Eungi Yang, Michael Randall, Yashi Ahmed. Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH.

263B
Context-dependent Transcriptional Cofactors Regulate Specific Wnt Target Genes. Ai Tian, Hassina Benchabane, Nan Xin, Yashi Ahmed. Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH.

264C
Drosophila Tankyrase Regulates Axin Through Cell Membrane Recruitment and Proteolysis. Zhenghan Wang, Ofelia Tacchelly Benites, Eungi Yang, Geoffrey Noble, Megan Johnson, Michael Randall, Yashi Ahmed. Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH.

Cell Cycle and Cell Death

265A
Control of stalk cell number and morphology. Antoine Borensztejn¹, Anne-Marie Pret², Kristi Wharton¹. 1) Brown University, Department of Molecular Biology, Cell Biology, and Biochemistry, Providence, RI; 2) CNRS, Centre de Génétique Moléculaire, Gif-Sur-Yvette, France.

266B
Apoptotic priming is regulated during Drosophila development. Yunsik Kang, Arash Bashirullah. Sch Pharmacy, Univ Wisconsin, Madison, Madison, WI.

267C
Autophosphorylation of DBT Occurs in its C-terminal Domain and is required for its Antiapoptotic Function. John C. Means, Jin-Yuan Fan, Ed Bjes, Jeffrey Price. University of Missouri-Kansas City, Kansas City, MO.

268A
The regulation of Dronc by Hippo Pathway. Shilpi Verghese¹, Aidan Fenix¹, Madhuri Kango-Singh^1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) Pre-Medical Programs, University of Dayton, Dayton OH; 3) Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton OH.

269B
Modeling of spreading cell death by necrosis neurons to adjacent cells in Drosophila. Yong Yang, Lin Hou, Lei Liu. Peking University, Beijing, China.

270C
Polyploidy Rewires The Spindle Assembly Checkpoint. Benjamin M. Stormo¹, Ruth Montague², Sarah Paramore², Don Fox^1,2. 1) Department of Cell Biology, Duke University, Durham, NC; 2) Department of Cancer Biology and Pharmacology, Duke University, Durham, NC.

271A
Identification of novel regulators of apoptosis during metamorphosis. Gina Castelvecchi¹, Yunsik Kang¹, Anne Sapiro², Sarah Ives¹, Arash Bashirullah¹. 1) Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; 2) Department of Genetics, Stanford University, Stanford, California, United States of America.

272B
Identification of genes that mediate steroid- and TNF-triggered non-apoptotic cell death. Gautam Das, Tsun-Kai Chang, Sudeshna Dutta, Charles Nelson, Emily Clough, Cheng-Yu Lee, Daniel Caffrey, Eric Baehrecke. Cancer Biology, University of Massachusetts Medical School, Worcester, MA.

273C
Invadolysin, a novel and essential metalloprotease, is involved in the activation of apoptosis. Michal M. Janiszewski, Christopher G. Mills, Catherine M. Rose, Cristina Aguilar, Samantha J. Littler, Margarete M. S. Heck. University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.

274A
Uncovering novel targets of Escargot-inhibited cell death in the Drosophila ovary by RNA-seq. Victoria Kathryn Jenkins, Kim McCall. Department of Biology, Boston University, Boston, MA.

275B
Engulfment Receptors in Programmed Cell Death in the Drosophila Ovary. Tracy L. Meehan, Allison Timmons, Jon Iker Etchegaray, Jeffrey Taylor, Olivia Rudnicki, Sarah Yunes, Kim McCall. Department of Biology, Boston University, Boston, MA.

276C
Inhibiting both autophagy and caspases does not abolish nurse cell death in late stage egg chambers. Jeanne S. Peterson, Alla Yalonetskaya, Kim McCall. Dept Biol, Boston Univ, Boston, MA.

277A
A non-cell-autonomous contribution of somatic cells to programmed cell death of the germline in Drosophila. Claire E. Schenkel, Jon Iker Etchegaray, Kim McCall. Biology, Boston University, Boston, MA.

278B
The contribution of follicle cells to non-apoptotic programmed cell death of nurse cells during late oogenesis. Allison Timmons, Claire Schenkel, Jon Iker Etchegaray, Jeffrey Taylor, Olivia Rudnicki, Kim McCall. Biology, Boston University, Boston, MA.

279C
Molecular characterization of cell competition and compensatory cell proliferation in Drosophila. Li He. Genetics, Harvard Medical School, Boston, MA.

280A
Overexpression of DNA polymerase theta (Pol theta) in Drosophila melanogaster causes reduced hatch rate and sensitivity to nitrogen mustard. Anna Dukhovich, Kelly Beagan, Mitch McVey. Biology Department, Tufts University, Medford, Ma.

281B
DR-white measures double-strand break repair pathways in Drosophila melanogaster. Jeannine R. LaRocque, Margot Le Neveu, Anthony Do. Department of Human Science, School of Nursing and Health Studies, Georgetown University, Washington, DC 20057.

282C
The Smc5/6 complex confers resistance to caffeine and genotoxic stress and plays a role in cell cycle regulation and cell survival in Drosophila melanogaster. Xiao Li¹, Ran Zuo², Stanley Tiong², Francesca Di Cara², Kirst King-Jones², Sarah C. Hughes¹, Shelagh D. Campbell², Rachel Wevrick¹. 1) Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada; 2) Department of Biological Sciences, University of Alberta.

283A
Mu2 cooperates with p53 to regulate fusion of dysfunctional telomeres in Drosophila. Sarah R. Oikemus, Hannah Pham, Michael Brodsky. Dept PGF&E, Univ Massachusetts, Worcester, Worcester, MA.

284B
Regulation of the translesion DNA polymerase eta by the E3 ubiquitin ligase NOPO. Heather A. Wallace¹, Julie A. Merkle², Laura A. Lee¹. 1) Cell and Developmental Biology, Vanderbilt University, Nashville, TN; 2) Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ.

285C
An mCherry-tagged Gemini Bac transgene provides a biosensor throughout D. melanogaster development and a tool for studying Geminin function. Robert C. Eisman, Samantha Young, Melissa A. S. Phelps, Amelia D. Tomlinson, Stacy L. Holtzman, Brian R. Calvi, Thomas C. Kaufman. Dept Biol, Jordan Hall A505, Indiana Univ, Bloomington, IN.

286A
Loss of the Werner’s Syndrome exonuclease sensitizes flies to replication stress and promotes tumorigenesis. Mitch McVey¹, Elyse Bolterstein¹, Rachel Rivero¹, Robert Salomon². 1) Tufts University, Medford, MA; 2) Tufts Medical Center, Boston, MA.

287B
Functional dissection of Mcm10: exploring the essential functions of a replication factor. Michael C. Reubens, Tim W. Christensen. Biology, East Carolina University, Greenville, NC.

288C
Investigating the Interaction of RecQ4 and Mcm10 in Drosophila melanogaster. Wayne A. Rummings, Tim W. Christensen. Biology, East Carolina University, Greenville, NC.

289A
Genome damage triggers non-canonical cell death during Drosophila polyploid mitosis. Heidi Bretscher, Don Fox. Duke University, Durham, NC.

290B
Interactions between purine synthesis and cell death pathways. Denise V. Clark, Ashley M. DiPasquale. Dept of Biology, Univ New Brunswick, Fredericton, NB, Canada.

291C
Cdc20/fizzy maintains neural stem cells by suppressing necrotic cell death. Cheng-Yu Lee^1,2,3,4, Chaoyuan Kuang^4,5. 1) Center for Stem Cell Biology, Life Sciences Institute; 2) Division of Molecular Medicine and Genetics, Department of Internal Medicine; 3) Department of Cell and Developmental Biology; 4) Program in Cellular and Molecular Biology,; 5) Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI 48109.

292A
Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation. Bertrand Mollereau¹, Marie-Laure Dichtel-Danjoy¹, Dali Ma¹, Pierre Dourlen¹, Gilles Chatelain¹, Francesco Napoletano¹, Marion Robin¹, Marlene Corbet¹, Clemence Levet¹, Hind Hafsi², Pierre Hainaut², Hyung Don Ryoo³, Jean Christophe Bourdon⁴. 1) LBMC UMR5239, Ecole Normale Superieure, Lyon, France; 2) International Agency for Research on Cancer, Lyon, France; 3) Department of Cell Biology, New York University School of Medicine, New York, NY, USA; 4) European Associated Laboratory University of Dundee/Inserm U858, Department of surgery and Molecular Oncology, Dundee, DD1 9SY UK.

293B
Anastasis: An unexpected route to rescue dying cells, and its physiological and pathological implications. Ho Lam Tang, Ho Man Tang, Denise Montell. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD.

294C
Generation of transaldolase knockdown Drosophila in the apoptosis study and screening for the apoptosis modifiers. Yi-Chun Chen, Tzu-Li Yen, Ju-Ching Yu, Horng-Dar Wang. Institute of Biotechnology, HsinChu, Taiwan.

295A
JAK/STAT signaling controls loss of polarity and apoptosis for elimination of supernumerary polar cells in the Drosophila ovary. Anne-Marie Pret^1,2, Antoine Borensztejn^1,3, Alba Torres^1,4, François Agnès^1,4. 1) Centre de Génétique Moléculaire, CNRS UPR3404, Gif-sur-Yvette, France; 2) Université de Versailles-St Quentin, Versailles, France; 3) Université Pierre et Marie Curie, Paris, France; 4) Université Paris-Sud, Orsay, France.

296B
How Do Endocycling Cells Block Apoptosis? Bingqing Zhang, Brian R. Calvi. Biology, Indiana University, Bloomington, IN.

297C
Regulation of life or death fate in Drosophila neural stem cells. Richa Arya, Ying Tan, Hsiao-Yu Huang, Francisca Rodriguez, Tatavik Keshishyan, Megumu Yamada-Mabuchi, Kristin White. CBRC, MGH/HARVARD, CHARLESTOWN, MA.

298A
Dpp signaling counteracts JNK-dependent apoptosis caused by epithelial disruption. Jorge V. Beira^1,2, Jean-Paul Vincent¹. 1) Developmental Biology Division, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, United Kingdom; 2) Research Department of Cell and Developmental Biology, University College London, Gower Street, London, United Kingdom.

Cell Division and Growth Control

299B
A novel screen to identify regulators of cell competition in Drosophila. Justin A. Bosch, Iswar Hariharan. Molecular and Cell Biology, University of California - Berkeley, Berkeley, CA.

300C
“Divide and rule”: cell mixing induced by winner cells is required for loser cell elimination during cell competition. Romain V. Levayer, Eduardo Moreno. IZB institute für Zellbiologie, University of Bern, Bern, Bern, Switzerland.

301A
Analysis of Yorkie activity in scribble mutant cells challenged with different cell competitive environments. Indrayani Waghmare¹, Shilpi Verghese¹, Alyssa Lesko^2,3, Amit Singh^1,4,5, Madhuri Kango-Singh^1,4,5. 1) Department of Biology, University of Dayton, Dayton, OH; 2) University of Dayton Honors Program, Dayton, OH; 3) Department of Chemistry, University of Dayton, Dayton, OH; 4) Pre Medical Program, University of Dayton, Dayton, OH; 5) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

302B
The bHLH proteins Emc and Da control cell cycle progression through the transcriptional regulation of the Cdc25 phosphatase string, during Drosophila development. Irene Andrade-Zapata, Antonio Baonza. Centro de Biología Molecular Severo Ochoa, Madrid, Spain.

303C
Nutrition/TOR signaling promotes growth via the conserved Pol I transcription factor, TIF-IA in Drosophila. Abhishek Ghosh, Savraj S. Grewal. Clark H. Smith Brain Tumor Centre, SACRI, University of Calgary, Calgary, AB, T2N 4N1, Canada.

304A
Transcriptional Mediators of Growth and Survival Downstream of the Target of Rapamycin (TOR) Pathway. Lauren E. Killip, Savraj Grewal. Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada.

305B
Scribble acts in the Drosophila Fat-Hippo pathway to regulate Warts activity. Shilpi Verghese¹, Indrayani Waghmare¹, Hailey Kwon¹, Katelin Hanes¹, Madhuri Kango-Singh^1,2,3. 1) Department of Biology, University of Dayton, Dayton, OH; 2) Pre-Medical Programs, University of Dayton, Dayton OH; 3) Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton OH.

306C
Drosophila RNase Z^L is involved in cell growth and cell cycle progression. Xie Xie, Edward Dubrovsky. Biological Sciences, Fordham University, Bronx, NY.

307A
Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. Tamara Zoranovic¹, Aloma Rodrigues¹, Aidee Ayala-Camargo¹, Savraj Grewal², Tamara Reyes-Robles¹, Michelle Krasny¹, D. Christine Wu³, Laura Johnston³, Erika Bach¹. 1) Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA; 2) Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada; 3) Department of Genetics and Development, Columbia University, New York, NY, USA.

308B
Polyploid Hindgut Cells in Drosophila Undergo Multipolar Mitosis and Tolerate Aneuploidy. Kevin Schoenfelder¹, Ruth Montague², Sarah Paramore², Donald Fox^1,2. 1) Duke University Program in Genetics and Genomics, Durham, NC 27710; 2) Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710.

309C
Interplay between the dividing cell and its neighbors temporally and spatially regulates adherens junction formation during cytokinesis in epithelial tissue. Sophie Herszterg¹, Andrea Leibfried², Floris Bosveld¹, Charlotte Martin¹, Yohanns Bellaiche¹. 1) Polarity Division and Morphogenesis Team, Institut Curie, CNRS UMR 3215, INSERM U934, 26 rue d’Ulm, 75248 Paris Cedex 05, France; 2) Present address: Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

310A
Chromosome condensation and the evolution of Drosophila karyotypes. Shaila Kotadia, William Sullivan. Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA.

311B
Insulin signaling controls mitose/ endocycle switch through Notch signaling during drosophila oogenesis. Patrick Jouandin, Stéphane Noselli. Insitut Biologie Valrose (iBV), Nice, Alpes Maritimes (06), France.

312C
dLipin interacts with the insulin signaling pathway in the control of fat metabolism and growth. Michael Lehmann, Sandra Schmitt. Dept Biological Sci, Univ Arkansas, Fayetteville, AR.

313A
CENP-E is required for chromosome bi-orientation in meiosis in Drosophila females. Tranchau L. Hoang¹, Sarah J. Radford², Kim S. McKim^1,2. 1) Genetics Department, Rutgers University, Piscataway, NJ; 2) Waksman Institute, Rutgers University, Piscataway, NJ.

314B
Discovery of B Chromosomes in Drosophila Melanogaster That Causes Female Specific 4th Chromosome Nondisjunction. Elisabeth Bauerly¹, Stacie Hughes¹, R. Scott Hawley^1,2. 1) Stowers Institute for Medical Research, Kansas City, MO; 2) Department of Molecular and Integrative Physiology, Kansas University Medical Center Kansas City, Kansas 66160, USA.

315C
Discovering new genes required for mitosis and meiosis by analysis of interactions with the kinesin Subito. Daniel J. DiSanto, Arunika Das, Kim S. McKim. Waksman Institute, Rutgers University, Piscataway, NJ.

316A
Heterochromatin Proteins Required for Association of Achiasmate Homologous Chromosomes in Drosophila Oocytes. Christopher C. Giauque, Sharon E. Bickel. Biological Sciences, Dartmouth College, Hanover, NH.

317B
Analysis of synaptonemal complex initiation. Mercedes R. Gyuricza¹, Kathryn B. Landy¹, Sanese K. White- Brown², Kim S. McKim¹. 1) Waksman Institute, Rutgers University, NJ; 2) UMDNJ, Piscataway, NJ.

318C
Topoiosomerase II is required for the proper separation of heterochromatic regions during female meiosis. Stacie E. Hughes¹, R. Scott Hawley^1,2. 1) Stowers Inst Med Res, Kansas City, MO; 2) Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, Kansas.

319A
SUN is required to maintain centromere cohesion and for proper chromosome segregation during meiosis in both male and female Drosophila melanogaster. Badri Krishnan¹, Sharon Thomas¹, Hirotsugu Yamada¹, Rihui Yan¹, Bruce McKee^1,2. 1) Biochemistry and Cellular and Molecular biology, University of Tennessee, Knoxville, TN; 2) Genome Science and Technology program, University of Tennessee, Knoxville, TN.

320B
Exploring SOLO Working Mechanism in Drosophila Meiosis Cohesin Complex. Qian Ma, Bruce McKee. Univ of Tennessee, Knoxville, Knoxville, TN.

321C
Recombination and the Function of Chromosome Pairing Sites. John R. Merriam. Dept Molec/Cell/Dev Biol, Univ California, Los Angeles, CA.

322A
Role Of Cohesins In Drosophila Male Meiosis. Avik Mukherjee¹, Bruce McKee^1,2. 1) Genome Science and Technology, University of Tennessee, Knoxville, TN; 2) Department of Biochemistry Cell and Molecular Biology, University of Tennessee, Knoxville, TN.

323B
The role of mcm5 and mad2 in the Pachytene checkpoint in Drosophila females. Anshu A. Paul, Kim S. McKim. Waksman Institute of Microbiology, Rm 206, Genetics, Rutgers, New Brunswick, New Brunswick, NJ.

324C
Temporal Analysis of DSB Formation in Meiotic Prophase Heterochromatin. Marissa C. Pelot¹, R. Scott Hawley^1,2. 1) Stowers Institute for Medical Research, Kansas City, MO 64110; 2) Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160.

325A
Regulation and Function of the Drosophila Shugoshin, MEI-S332. Belinda Pinto, Cristina Nogueira, Terry Orr-Weaver. Whitehead Inst, Cambridge, MA.

326B
A Novel Role for Sister-Chromatid Cohesion Proteins in Promoting Heterochromatin Mediated Association of Achiasmate Homologs in Drosophila Oocytes. Brian C. Seitz, Sharon E. Bickel. Biological Sciences, Dartmouth College, Hanover, NH.

327C
Euchromatic homology is sufficient for pairing of rDNA-deficient X chromosomes in male meiosis. John E. Tomkiel, Andrew Bourgeios, Christina Morgan, Katie Hansen, Kayla Hill, Aboubakar Doura. Dept Biol, Univ North Carolina, Greensboro, NC.

328A
Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation. Katherine A. Weng, Charlotte A. Jeffreys, Sharon E. Bickel. Biological Sciences, Dartmouth College, Hanover, NH.

329B
Role and regulation of BubR1 on acentric chromosome segregation. Nicolas Derive¹, Zohra Rahmani², Anne Royou¹. 1) Institut Européen de Chimie et Biologie, CNRS, Université Bordeaux Segalen, 2 rue Robert Escarpit, 33607 Pessac, France; 2) Institut Jacques Monod, CNRS, Université Paris Diderot Paris 7, 4 rue Marie-Andrée Lagroua Weill-Halle, 75205 Paris, France.

330C
Lipid droplets buffer the histone supply of Drosophila embryos. Zhihuan Li, Michael Welte. Department of Biology, University of Rochester, Rochester, NY.

331A
Maternal PIWI proteins are essential for embryonic mitosis and chromatin integrity. Sneha Mani¹, Heather Megosh², Haifan Lin¹, *First and second authors equally contributed to this work. 1) Cell Biology, Yale University, New Haven, CT; 2) Cell Biology, Duke University, Durham, NC.

332B
An in situ analysis of Drosophila imaginal disc regeneration: pattern reorganisation occurs independently of cell proliferation. Sandra Diaz-Garcia, Antonio Baonza. Development and Genetics Dept, CBMSO-UAM (CSIC), Madrid, Spain.

333C
A genetic approach to enhancing tissue regeneration. Robin Harris, Iswar Hariharan. University of California, Berkeley, Berkeley, CA.

334A
Identifying a transcriptional program that regulates compensatory proliferation. Joy H. Meserve¹, Robert J. Duronio². 1) Curriculum in Genetics and Molecular Biology, UNC, Chapel Hill, NC; 2) Departments of Biology and Genetics, UNC, Chapel Hill, NC.

335B
Trithorax is required for imaginal disc regeneration. Andrea Skinner, Rachel Smith-Bolton. Cell & Developmental Biology, University of Illinois Urbana-Champaign, Urbana, IL.

336C
A novel role for cytokinesis proteins in acentrosomal spindle assembly and chromosome segregation in Drosophila oocytes. Arunika Das¹, Shital J. Shah², Kim S. McKim¹. 1) Waksman Institute, Rutgers University, NJ; 2) New Jersey Medical School, Newark.

337A
Drosophila tumor suppressors maintain epithelial integrity by controlling mitotic spindle orientation. Yu-ichiro Nakajima, Emily Meyer, Matthew Gibson. Stowers Institute for Medical Research, Kansas City, MO.

338B
Chromosome segregation without spindle microtubules. Peter Vilmos¹, Szilard Szikora^1,2, Ferenc Jankovics¹, Ildiko Kristo¹, Laszlo Henn¹, Miklos Erdelyi¹. 1) Dept Genetics, Biological Research Center, Szeged, Hungary; 2) Dept Biology, University of Szeged, Szeged, Hungary.

339C
Mitotic epithelial cells have a dynamic relationship with the layer. Daniel T. Bergstralh, Holly Lovegrove, Daniel St. Johnston. Gurdon Inst, Univ Cambridge, Cambridge, United Kingdom.

340A
Role of Polyploid Glial Cells in Drosophila Neural Development. Laura E. Frawley, Yingdee Unhavaithaya, Terry L. Orr-Weaver. Whitehead Institute for Biomedical Research, Cambridge, MA.

341B
Activation and function of TGFβ signalling during Drosophila wing development and its interactions with the BMP pathway. Covadonga F. Hevia, Jose F. de Celis. Centro de Biología Molecular Severo Ochoa CSIC-UAM, Madrid, Spain.

342C
Growth is coordinated during regeneration through the regulation of ecdysone by Dilp8 via nitric oxide signaling. Jacob Jaszczak, Anh Dao, Adrian Halme. Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA.

343A
A screen to identify genes involved in tissue specific growth of the larval trachea in Drosophila. Paulo Leal, Robert Ward. Dept Molecular Biosciences, University of Kansas, Lawrence, KS.

344B
Two-tiered control of epithelial growth and autophagy by the insulin receptor and the Ret-like receptor, Stitcher. Fergal O'Farrell^1,2, Shenqiu Wang², Christos Samakovlis², Tor Erik Rusten¹. 1) Dept. of Biochemistry, Institute for Cancer Research The Norwegian Radium Hospital Oslo, Norway; 2) Department of Developmental Biology, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

345C
An in vivo RNAi screen for novel regulators of the Hippo pathway in organ size control. Carole Poon^1,2, Xiaomeng Zhang^1,2,3, Jane Lin^1,2, Samuel Manning^1,2,3, Kieran Harvey^1,2,3. 1) Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; 2) Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia; 3) Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.

346A
Drosophila models for XPB-related cancer predisposition. Leonie M. Quinn¹, Naomi C. Mitchell¹, Arjun Chahal¹, Mendis Peter¹, Amandine Michaud-Cartier¹, Ross D. Hannan². 1) Anatomy, University of Melbourne, Melbourne, Victoria 3010, Australia; 2) Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne Victoria 3002, AUSTRALIA.

347B
The Hippo signaling pathway plays a role in homeostatic growth of soma and germ line in the D. melanogaster larval ovary. Didem P. Sarikaya, Cassandra G. Extavour. Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.

348C
A novel mechanism for Emc transcriptional regulation of Notch-mediated proliferation in Drosophila. Carrie M. Spratford, Justin P. Kumar. Biology, Indiana University, Bloomington, IN.

349A
Mask proteins are cofactors of Yorkie/YAP in the Hippo pathway. Barry J. Thompson, Clara M. Sidor. London Research Institute, Cancer Research UK, London, United Kingdom.

350B
Distinct replication mechanisms leading to polyploidy. Jessica R. Von Stetina¹, Noa Sher¹, George Bell¹, Shinobu Matsuura², Katya Ravid², Terry L. Orr-Weaver¹. 1) Whitehead Inst, Dept. of Biol., MIT, Cambridge, MA; 2) Boston University Medical School, Boston MA.

351C
Characterization of a novel Merlin and Sip1 interaction region. Namal Abeysundara, Albert Leung, Sarah C. Hughes. University of Alberta, Edmonton, Canada.

352A
Characterizing the interaction between dCAF1-p180 and the tumor suppressor Merlin. Patrick Delaney, Pam Vanderzalm, Richard Fehon. Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.

353B
Hippo Activation through Homo-dimerization and Membrane Association for Growth Inhibition and Organ Size Control. Yaoting Deng¹, Yurika Matsui², Yifan Zhang³, Zhi-Chun Lai^1,2,3,4. 1) Biochemistry and Molecular Biology, Penn State University, University Park, PA; 2) Intercollege Graduate Degree Program in Cell and Developmental Biology; 3) Intercollege Graduate Degree Program in Genetics; 4) Department of Biology.

354C
Investigation of the genetic interactions between the Hippo signaling pathway and Drosophila C-terminal Src kinase (dCsk). Hailey J. Kwon^1,2, Indrayani Waghmare¹, Shilpi Verghese¹, Madhuri Kango-Singh^1,3,4. 1) Department of Biology, University of Dayton, Dayton, OH; 2) University of Dayton Honors Program, Dayton OH; 3) Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton OH; 4) PreMedical Programs, University of Dayton, Dayton OH.

355A
Signalling pathways controlling transcription of the myc oncogene and cell overgrowth in Drosophila via Psi. Amanda Jue Er Lee¹, Nicola Cranna¹, Naomi Mitchell¹, David Levens³, Ross Hannan², Leonie Quinn¹. 1) Anatomy and Neuroscience, University of Melbourne, Parkville, VIC, Australia; 2) Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; 3) National Cancer Institute, Bethesda, Maryland, United States.

356B
Functional and Genetic Analysis of Compensatory Responses Induced in Tumors Caused by Loss of Scribble (apical-basal polarity). Alyssa Lesko^1,2, Shilpi Verghese³, Indrayani Waghmare³, Madhuri Kango-Singh^3,4,5. 1) Department of Chemistry,University of Dayton, Dayton, OH; 2) Department of Mathematics, University of Dayton, Dayton, Oh; 3) Department of Biology, University of Dayton, Dayton, OH; 4) Pre-Medical Programs, University of Dayton, Dayton OH; 5) Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton OH.

357C
Effects of the endocrine hormone ecdysone on neoplastic tumorigenesis. Thu H. Tran, Rebecca Garrett, Katherine Pfister, Adrian Halme. Cell Biology, University of Virginia School of Medicine, Charlottesville, VA.

358A
A non-transcriptional role for Hippo pathway signaling. Pam Vanderzalm, Richard Fehon. Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL.

359B
Effect of novel phosphorylation sites on the function of the tumor suppressor Merlin. Sophia Yip, Angela Effa, Sarah Hughes. University of Alberta, Edmonton, Canada.

Chromatin and Epigenetics

360C
Assembly and function of centromeric chromatin in Drosophila meiosis. Nicole L. Beier^1,2, Elaine M. Dunleavy^2,3, Walter Gorgescu⁴, Jonathan Tang⁴, Sylvain V. Costes⁴, Gary H. Karpen^1,2. 1) Department of Molecular and Cell Biology, University of California, Berkeley, CA; 2) Department of Genome Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA; 3) National University of Ireland, Galway, Ireland; 4) Department of Cancer and DNA Damage Responses, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA.

361A
Mitotic chromosome phenotypes associated with a panel of Mcm10 mutants in Drosophila. Ritu Dalia, Michael Reubens, Tim W. Christensen. Biology Dept, East Carolina University, Greenville, NC.

362B
Redundant PREs act together to maintain en/inv gene expression. Sandip De, Judith Kassis. NICHD, NIH, BETHESDA, MD.

363C
Chromosome conformation capture and ecdysone signaling: insights into the regulation of early genes. Travis J. Bernardo, Xie Xie, Edward Dubrovsky. Fordham University, 441 East Fordham Road, Bronx, NY 10458.

364A
The SCF^Slimb ubiquitin ligase directly targets condensin II for degradation and functions to modulate 3D interphase chromosome spatial organization. Giovanni Bosco¹, Daniel W. Buster², Scott G. Daniel², Huy Q. Nguyen¹, Sarah L. Windler³, Maureen Peterson¹, Meredith Roberts², Joy H. Meserve², Tom Hartl², Joey E. Klebba², David Builder³, Gregory C. Rogers². 1) Genetics & Norris Cotton Cancer Ctr, Geisel Sch Med at Dartmouth, Hanover, NH; 2) Department of Cellular and Molecular Medicine, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA; 3) Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

365B
Condensin II mediated interphase chromosome compaction drive changes in nuclear architecture. Julianna Bozler¹, Huy Nguyen¹, Tom Hartl², Christopher Bauer², Gregory Rogers², Giovanni Bosco¹. 1) Geisel School of Medicine, Dartmouth College, Hanover, NH; 2) Molecular and Cellular Biology, University of Arizona, Tucson, AZ.

366C
Mis-expession of HipHop rescues cell lethality following telomere loss. Rebeccah L. Kurzhals¹, Laura Fanti², Sergio Piminelli², Yikang Rong³, Kent Golic⁴. 1) Department of Biology, Southeast Missouri State University, Cape Girardeau, MO; 2) University of Rome, “La Sapienza”, Rome, Italy; 3) National Cancer Inst., Bethesda, MD 20892; 4) University of Utah, Salt Lake City, UT 84112.

367A
PARP-1 marks mitotic chromatin and regulates post-mitotic transcription. Niraj Lodhi, Alexei Tulin. Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, Philadelphia, PA.

368B
Homeostasis of interphase chromosome length is maintained by the SCF^Slimb E3 Ubiquitin ligase direct targeting of the Cap-H2 subunit of condensin II. Huy Nguyen¹, Christopher Bauer², Maureen Peterson¹, Daniel Buster⁴, Scott Daniel², Gregory Rogers^3,4, Giovanni Bosco¹. 1) Geisel School of Medicine, Dartmouth College, Hanover, NH; 2) Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ; 3) Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ; 4) Arizona Cancer Center, University of Arizona, Tucson, AZ.

369C
Condensin II inhibits heterochromatic gene silencing and facilitates transposon silencing. Maureen Peterson¹, Christopher Bauer², John Manak³, Stephen Butcher³, Giovanni Bosco¹. 1) Genetics, Dartmouth College, Hanover, NH; 2) New York University Center for Genomics and Systems Biology; 3) University of Iowa Department of Biology.

370A
Interactions of HP1a, HP1b, and HP1c. Nicole C. Riddle^1,2, Tingting Gu², Sarah C. R. Elgin². 1) Biology, The University of Alabama at Birmingham, Birmingham, AL; 2) Biology, Washington University in St. Louis, St. Louis, MO.

371B
CAP-D3, a subunit of Condensin II, regulates expression of Bithorax cluster genes. Kavitha R. Sarvepalli¹, Michelle S. Longworth^1,2. 1) Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA; 2) Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.

372C
The JIL-1 Kinase Does Not Phosphorylate H3S28 or Recruit 14-3-3 to Active Genes in Drosophila. Chao Wang, Changfu Yao, Yeran Li, Weili Cai, Jack Girton, Jørgen Johansen, Kristen M. Johansen. Biochemistry, Biophysics & Mol Biol, Iowa State University, Ames, IA.

373A
Mitotic telomere clustering in Drosophila melanogaster. Natalia Wesolowska, Yikang Rong. Lab of Biochemistry and Molecular Biology, National Institutes of Health, Bethesda, MD.

374B
Dosage compensation of the X chromosome and inverse effect on the autosomes in RNASeq analysis of triple X metafemales compared to normal females. James A. Birchler¹, Lin Sun¹, Adam Johnson¹, Jilong Li², Jianlin Cheng². 1) Division Biological Sci; 2) Department of Computer Sci, Univ Missouri, Columbia, MO.

375C
Targeting the MSL complex counteracts the effect of increased histone acetylation and does not induce dosage compensation. Lin Sun¹, Harvey Fernandez¹, Jilong Li², Jianlin Cheng², James Birchler¹. 1) Biological Sci Div; 2) Department of Computer Sci, Univ Missouri,Columbia, MO.

376A
Sex-specific heterochromatin: How does chromatin become male? Manasi Apte, Victoria Meller. Dept. of Biological Sciences, Wayne State University, Detroit, MI.

377B
Localization of Mini-chromosome Maintenance Protein 10. Nicholas W. Faulkner, Tim W. Christensen. East Carolina University, Greenville, NC.

378C
Developmental time-course of gene inactivation caused by position effect. Aleksei Shatskikh, Sergey Lavrov, Vladimir Gvozdev. Department of Molecular Genetics of Cell, Institute of Molecular Genetics of Russian Academy of Sciences, Moscow, Russian Federation.

379A
Enhancer-associated H3K4 mono-methylation by Trithorax-related. Hans-Martin Herz¹, Man Mohan¹, Alexander S. Garruss¹, Kaiwei Liang¹, Yoh-hei Takahashi¹, Kristen Mickey¹, Olaf Voets², C. Peter Verrijzer², Ali Shilatifard¹. 1) Shilatifard lab, Stowers Institute for Medical Research, Kansas City, MO; 2) Department of Biochemistry and Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.

380B
Role of nucleosome modification, composition, and position in specification of replication origins. Neha P. Paranjape, Jun Liu, Brian R. Calvi. Department of Biology, Indiana University, Bloomington, IN.

381C
Investigations of Drosophila Suppressor of Hairy-wing zinc-finger mutants identify distinct subclasses of genomic binding sites. Ryan M. Baxley¹, Michael W. Klein², Ashley G. Fell², Joel A. Morales-Rosado², James D. Bullard², Pamela K. Geyer^1,2. 1) Molecular & Cellular Biology Program, University of Iowa; 2) Biochemistry Department, University of Iowa, Iowa City, IA.

382A
Diversity in function: How a polydactyl zinc finger protein confers multiple functional outputs. James D. Bullard¹, Ryan M. Baxley², Jake M. Traxler¹, Bianca N. Mason¹, Pamela K. Geyer^1,2. 1) Biochemistry Department, University Of Iowa; 2) Molecular & Cellular Biology Program, University of Iowa, Iowa City, IA.

383B
Structure-function analysis of Argonaute2 in chromatin insulator activity. Madoka Chinen, Elissa Lei. Laboratory of Cellular and Developmental Biology, NIDDK, Bethesda, MD.

384C
The even skipped insulator Homie blocks Polycomb response element-mediated repression of the adjacent gene TER94. Miki Fujioka, James B. Jaynes. Dept Biochem. & Mol. Biol, Thomas Jefferson Univ, Philadelphia, PA.

385A
Characterization of an RNA Binding Protein Involved in Chromatin Insulation. Matthew R. King, Ryan K. Dale, Elissa P. Lei. National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

386B
Genome-wide localization of exosome components to active promoters and chromatin insulators. Su Jun Lim, Patrick Boyle, Madoka Chinen, Ryan Dale, Elissa Lei. Laboratory of Cellular and Developmental Biology, NIDDK, NIH, Bethesda, MD.

387C
Tissue-specific regulation of chromatin insulator function mediated by an RNA-binding protein. Leah H. Matzat, Ryan K. Dale, Nellie Moshkovich, Elissa P. Lei. Laboratory of Cellular and Developmental Biology, NIDDK, Bethesda, MD.

388A
Mechanisms of transcriptional regulation by a Drosophila insulator protein. Alexey A. Soshnev, Pamela K. Geyer. Molec & Cellular Biol, Univ Iowa, Iowa City, IA.

389B
Environmentally induced rDNA instability as a driver of epigenetic variation. John Aldrich, Keith Maggert. Department of Biology, Texas A&M University, College Station, TX.

390C
Analysis of Sex combs reduced HOX gene cis-regulatory elements. Monica T. Cooper, James A. Kennison. Program on Genomics of Differentiation, NIH, Bethesda, MD.

391A
Epigenetic regulation in Drosophila melanogaster via DNA methylation- a systems biology approach. Deepti D. Deobagkar, Chitra Pannikar. Department of Zoology, University of Pune, Pune, India,411007.

392B
Intercalary heterochromatin regions in salivary gland polytene chromosomes of Drosophila melanogaster tend to have conserved gene order across the genus Drosophila. Tatiana D. Kolesnikova, Natalya G. Andreyenkova, Elena S. Belyaeva, Fedor P. Goncharov, Tatyana Yu. Zykova, Lidiya V. Boldyreva, Galina V. Pokholkova, Igor F. Zhimulev. Institute of Molecular and Cellular Biology , Russian Academy of Sciences, Novosibirsk, Russian Federation.

393C
Gene Environment Interactions - Implications for Epigenesis. Yoav Soen. Biological chemistry, Weizmann Institute of Science, Rehovot, Israel.

394A
Wash interacts with Lamin and affects nuclear organization. Jeffrey M. Verboon, Hector Rincon, Tim Werwie, Tobias Ragoczy, Dave Scalzo, Steven Erikson, Jeff Delrow, Mark Groudine, Susan Parkhurst. Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N., Seattle, WA 98109.

395B
The telomeric retrotransposons in Drosophila are activated and replicated at the G1/S boundary. Liang Zhang, Yikang Rong. National Cancer Institute, Bethesda, MD.

396C
De novo establishment of Polycomb-mediated repression. Jumana S. AlHaj Abed, Judith Benes, Richard Jones. Dept. Of Biology, Southern Methodist University, Dallas, TX.

397A
Function of the bxd ncRNA. Ana Borges, Welcome Bender. bcmp, harvard medical school, boston, MA.

398B
Analysis of two closely-linked engrailed Polycomb Response Elements: similarities and differences. J. Lesley Brown, Judith Kassis. NICHD, NIH, Bethesda, MD.

399C
Drosophila taranis is an important mediator of Polycomb mediated transcriptional silencing. Pranabananda Dutta, Willis Li. Medicine, University of California, San Diego, La Jolla, CA.

400A
Polycomb group gene E(z) prevents germline-to-soma conversion in Drosophila adult testes. Suk Ho Eun, Xin Chen. Dept Biol, Johns Hopkins Univ, Baltimore, MD.

401B
Binding profile comparison of Tritrorax-like across Drosophila species. Lijia Ma, Nicolas Negre, Matt Slattery, Rebecca Spokony, Sasha Ostapenko, Ryan Ptashkin, Jennifer Zieba, Kevin White. Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL.

402C
Identification and characterization of DNA binding proteins necessary for epigenetic silencing by Polycomb group proteins. Payal Ray, Judith A. Kassis. Eunice Kennedy Shriver National Institutes of Child Health and Human Development, NIH, Bethesda, MD.

Drosophila Models of Human Diseases

403A
The EGFR/MAPK pathway is a target of developmental ethanol exposure in Drosophila.. Rachael L. French, Peter Luu, David Do, Nicole Delgado. Biological Sciences, San Jose State University, San Jose, CA.

404B
TSPO/PBR, a component of mPTP, modulates ethanol-related behaviors in Drosophila. Ran Lin, Douglas Wallace. Children's Hospital of Philadelphia Research Institute, Philadelphia, PA.

405C
The Role of Oxidative Stress in a Drosophila Model of Fetal Alcohol Syndrome. Theresa A. Logan-Garbisch¹, Kiara Y. Amaro-Rivera^1,2, Audrey A. Ford¹, David Do^1,3, Hilal J. Jarar¹, Melissa K. Ruiz¹, Omar Fateen¹, Rachael French¹. 1) Biological Sciences, San José State University, San José, CA; 2) Industrial Biotechnology Department, University of Puerto Rico-Mayagüez, Yaguez, Mayagüez, Puerto Rico; 3) Computer Science, San José State University, San José, CA.

406A
Psi regulates dmyc transcription via modulation of RNA Polymerase II. Nicola J. Cranna¹, Amanda Lee¹, Naomi Mitchell¹, Ross Hannan², Leonie Quinn¹. 1) Anatomy and Neuroscience, University of Melbourne, Melbourne, VIC, Australia; 2) Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

407B
Genomic and epigenetic changes occurring during carcinogenesis: A fly perspective. Delphine Fagegaltier¹, Mary-Lee Dequeant², Gregory Hannon¹, Norbert Perrimon², Amanda Simcox³, STARR Consortium. 1) CSHL - HHMI, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; 2) HHMI - Department of Genetics Harvard Medical School Boston, MA; 3) Department of Molecular Genetics Ohio State University Biological Sciences Columbus, OH.

408C
Regulation of E-cadherin expression by Poly(ADP-ribosyl)ation during Development and Tumorigenesis. Yingbiao Ji, Alexei Tulin. Cancer Biology Program, Fox Chase Cancer Ctr, Philadelphia, PA.

409A
Cell type-specific, BMP-dependent regulation of growth and migration by the ecdysone receptor in secondary cells of the male accessory gland. Aaron Leiblich^1,2, Michael Williams¹, Luke Marsden², Carina Gandy¹, Laura Corrigan¹, Shih-Jung Fan¹, Freddie Hamdy², Clive Wilson¹. 1) Deparment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; 2) Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

410B
Novel functions of the Drosophila Mps1 homologue, altered disjunction (ald), regulating epithelial integrity. Beatriz Perez San Juan, Antonio Baonza Cuenca. Developmental Biology, CBMSO, Madrid, Madrid, Spain.

411C
Alcohol and cancer: dietary alcohol enhances tissue overgrowth upon loss of Hippo Pathway signaling. Cathie M. Pfleger¹, Anoj Ilanges^1,2, Maryam Jahanshahi¹. 1) Dept Oncological Sci, Mount Sinai Sch Med, New York, NY; 2) Yale University, New Haven, CT.

412A
A troponin-t mutation initiates cardiomyopathy due to impaired contractile inhibition in Drosophila melanogaster. Anthony Cammarato¹, Meera Cozhimuttam Viswanathan¹, Gaurav Kaushik², Adam J. Engler², William Lehman³. 1) Johns Hopkins University, Baltimore, MD; 2) University of California, San Diego, San Diego, CA; 3) Boston University School of Medicine, Boston, MA.

413B
Pygopus Is Required for Age-dependent Maintenance of Heart Function Independent of Canonical Wnt Signaling. Karen Ocorr¹, Min Tang², Wuzhou Yuan², Xiushan Wu², Rolf Bodmer¹. 1) Dept Neuroscience & Aging, Sanford-Burnham Medical Research Institute, La Jolla, CA; 2) The Center for Heart Development, College of Life Science, Hunan Normal University, Changsha Hunan Province, P.R. 410081.

414C
New cellular functions for the Lowe Syndrome phosphoinositide phosphatase dOCRL in diverse Drosophila tissues. Sarah A. Biber, Abdulmuhsen Ali, Avital Rodal. Biology Department, Brandeis University, Waltham, MA.

415A
The role of Cad99C, the Drosophila Usher Syndrome Protocadherin, in light-induced eye degeneration and apical membrane dynamics. Se-Yeon Chung, Deborah Andrew. Dept Cell Biol, Johns Hopkins Univ, Baltimore, MD.

416B
Quantitative Gene Expression Analysis of Drosophila melanogaster in a Fetal Alcohol Spectrum Disorder Model. David Do, Theresa Logan, Peter Luu, Omar Fateen, Brianna Hagen, Janet Lafler, Luke Lajoie, Melissa Ruiz, Clare Wadsworth, Audrey Ford, Schehrbano Khan, Hilal Jarrar, Elizabeth Benn-Hirsch, Rachael French. Biological Sciences, San Jose State University, San Jose, CA.

417C
A Step Closer to Understanding Social Behavior: Social Interactions and Dopamine in Drosophila melanogaster. Robert W. Fernandez¹, Adesanya A. Akinleye¹, Marat Nurilov¹, Zulekha Rouzyi¹, Anne F. Simon^1,2. 1) School of Arts And Sciences, Department of Biology, The City Univ New York, York College, Jamaica, NY; 2) York College and The Graduate Center, The City University of New York.

418A
Drug Rescue of Repetitive Grooming Behaviors in Drosophila Fragile X Mental Retardation Mutants. Catalina Florez¹, Matthew Whitmill¹, Melissa Kepke¹, Linda Restifo², William Conner¹. 1) Department of Biology, Wake Forest University, Winston-Salem, NC 27106; 2) Department of Neuroscience and Neurology, and Center for Insect Science, University of Arizona, Tucson, AZ 86721.

419B
Fragile X Mental Retardation Protein Regulates Trans-Synaptic Signaling. Samuel H. Friedman, Neil Dani, Kendal Broadie. Department of Biological Sciences, Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37212 USA.

420C
Kismet-dependent regulation of glutamate receptors at the Drosophila Neuromuscular Junction. Rupa Ghosh¹, Srikar Vegesna¹, Hong Boa³, Bing Zhang³, Faith Liebl², Daniel Marenda¹. 1) Drexel University, Philadelphia, PA; 2) Univ of Southern Illinois at Edwardsville, IL; 3) Univ of Oklahoma, OK.

421A
Low Doses of Iron-Oxide Nanoparticles have a Detrimental Effect on Reproduction and Development. Benjamin W. Henderson¹, Rami R. Ajjuri¹, Sarah Boyd¹, Gavin Daigle¹, Yuping Bao², Janis M. O'Donnell¹. 1) Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35401; 2) Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL.

422B
Genes Cam and nAchRα-30D suppress mutant dystrophin phenotype in Drosophila melanogaster. Natalia Holub, Ruslana Mykula, Yaroslava Chernyk. Departament of Genetics and Biotechnology, Ivan Franko National University, lviv, Ukraine.

423C
ACSL4 inhibits synapse growth by attenuating BMP signaling via endocytic recycling of its receptors. Yan Huang, Zhihua Liu, Qifu Wang, Yong Q. Zhang. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

424A
Effects of Perfluoroocatanoic Acid (PFOA) on growth and development in the fruit fly, Drosophila melanogaster. AnnJosette Ramirez, Kristin Johndreau, Amber K. Weiner, Ashley Parker, Kara Bennett, Caroline Rachfalski, Sheryl Smith. Biology, Arcadia University, Glenside, PA.

425B
Immunity Defects in the Drosophila Model of Fragile X Syndrome. Elizabeth Stone, Mimi Shirasu-Hiza. Columbia University, New York City, NY.

426C
Novel Web-based, High-throughput Drosophila Computational Tool used to Investigate the role of UBE3A in Autism Spectrum Disorders. Ryan Turner¹, Rami R. Ajjuri², Larry Reiter³, Janis M. O'Donnell². 1) Computer-Based Honors Program, University of Alabama, Tuscaloosa, AL; 2) Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama; 3) Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee.

427A
Effects of Bisphenol A exposure on growth and onset of metamorphosis in Drosophila melanogaster. Amber K. Weiner, Ashley Parker, AnnJosette Ramirez, Kara Bennett, Kristin Johndreau, Caroline Rachfalski, Sheryl Smith. Biology, Arcadia University, Glenside, PA.

428B
Protein expression profiling of genes implicated in cognitive disorders. Monika Zuberova¹, Korinna Kochinke², Pavel Mejstrik¹, Annette Schenck², Pavel Tomancak¹. 1) Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; 2) Radboud University Medical Centre, Department of Human Genetics, Nijmegen, Netherlands.

429C
The Use of a Drosophila Laminin A Mutant as a Model for Gestational Diabetes. Joana M. Hubickey, Lauren Perkins- Ross, Laura K. Reed. University of Alabama , Tuscaloosa , AL.

430A
Functional characterization of ACN9 in Drosophila mitochondria. Wendou Yu¹, Daniel K. Bricker¹, James E. Cox², Dennis R. Winge³, Jared Rutter³, Carl S. Thummel¹. 1) Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT; 2) Metabolomics Core Research Facility, University of Utah School of Medicine, Salt Lake City, UT; 3) Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT.

431B
The Role of SOD1 in a Drosophila Model of Spinocerebellar Ataxia 3 (Machado-Joseph's Disease). Christopher Acquafredda, John Warrick. University of Richmond, Richmond, VA.

432C
Catecholamines-up modulates alpha-synuclein- induced neurotoxicity in a Parkinson’s disease model. Rami R. Ajjuri, Faiza Ferdousy, Janis M. O'Donnell. Department of Biology, University of Alabama, Box 870344, Tuscaloosa, AL, 35487-0344.

433A
Drosophila Tau is Required for Proper Maintenance and Survival of Neurons. Bonnie J. Bolkan, Doris Kretzschmar. CROET, L606, Oregon Hlth & Sci Univ, Portland, OR.

434B
The role of SOD2 and autophagy in a Drosophila model of Machado-Joseph Disease. Natalie M. Clark, John M. Warrick. Department of Biology, University of Richmond, Richmond, VA.

435C
TDP-43 neurotoxicity due to loss-of-function in Map205-dependent steroid receptor-mediated gene program switching in Drosophila. Bart Dermaut^1,2, Lies Vanden Broeck², Marina Naval Sanchez³, Yoshitsugu Adachi⁴, Danielle Diaper⁴, Pierre Dourlen¹, Julien Chapuis¹, Gernot Kleinberger⁵, Marc Gistelinck², Christine Van Broeckhoven⁵, Jean-Charles Lambert¹, Frank Hirth⁴, Stein Aerts³, Patrick Callaerts². 1) Inserm U744, Institut Pasteur de Lille, University of Lille 2, Lille, France; 2) Laboratory of Behavioral and Developmental Genetics, VIB Center for the Biology of Disease, University of Leuven, Belgium; 3) Laboratory of Computational Biology, Center of Human Genetics, University of Leuven, Belgium; 4) MRC Centre for Neurodegeneration Research, King's College London, Department of Neuroscience, Institute of Psychiatry, London, UK; 5) Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, VIB, Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium.

436A
Photoreceptor cell death triggered by rhodopsin aggregation requires immunity signaling and transcriptional activation through NF-kB. Patrick J. Dolph, Ron Kinser, Yashodhan Chinchore. Biological Sciences, Dartmouth College, Hanover, NH.

437B
The role of Swiss cheese, the Drosophila homologue of Neuropathy target esterase, in glia development. Sudeshna Dutta, Janis McFerrin, Bruce Patton, Doris Kretzschmar. CROET, Oregon Health and Science University, Portland, OR.

438C
A novel rationally designed chaperone that blocks amyloid beta neurotoxicity. Shailaja Emani^1,2, Swati Khare¹, Alfonso Martin-Pena¹, Yan Zhang¹, Pedro Fernandez-Funez¹, Diego Rincon-Limas¹. 1) Neurology, University of Florida, Gainesville, FL; 2) HHMI-UF Science for Life.

439A
Discovery of SAD, a novel gene required for axonal integrity in ageing, by an unbiased genetic screen using the Drosophila wing as a model. Yanshan Fang, Xiuyin Teng, Yongqing Zhu, Nancy Bonini. HHMI, Dept. of Biology, Univ. of Pennsylvania, Philadelphia, PA 19104.

440B
Anti-Aβ miniantibodies suppress Aβ42 neurotoxicity in flies. Pedro Fernandez-Funez^1,2,3, Swati Khare¹, Krishanu Mathur¹, Alfonso Martin-Peña¹, Diego Rincon-Limas^1,2. 1) Dept Neurology; 2) Dept Neuroscience; 3) Genetics Institute and Center for Translational Research on Neurodegenerative Diseases; University of Florida, Gainesville, FL.

441C
Repeat Associated Non-AUG initiated Translation mediates neurodegeneration in a Drosophila models of Fragile X-associated Tremor Ataxia Syndrome. Michelle A. Frazer¹, Fang He², Peter K. Todd². 1) Cellular & Molecular Biology, University of Michigan, Ann Arbor, MI; 2) Neurology, University of Michigan, Ann Arbor, MI.

442A
Effects of Nicotine and Indole-3-carbinol on Rotenone-induced Drosophila model of Parkinson’s disease. Cassie K. Huang, Jessie Rottersman, S. Tariq Ahmad. Biology, Colby College, Waterville, ME.

443B
A large-scale RNAi screen to identify novel modifiers of polyglutamine toxicity in Drosophila. Sara Imarisio¹, Ashley R. Winslow², Benjamin R. Underwood³, Wun Lam¹, Evangelia K. Ttofi², Viktor I. Korolchuk⁴, Jörg Gsponer⁵, M. Madan Babu⁶, David C. Rubinsztein². 1) Department of Genetics, University of Cambridge, Cambridge , UK; 2) Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research,Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0XY, UK; 3) Norfolk and Suffolk Huntington’s Disease Service, Mental Health Team, Newmarket Hospital, Newmarket, Suffolk CB8 7JG, UK; 4) Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK; 5) Centre for High-Throughput Biology, The University of British Columbia, 2125 East Mall, Vancouver, BC V6T 1Z4, Canada; 6) Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

444C
FUS/TLS mutations disrupt axonal transport, synaptic development, and synaptic function: a screen for genetic modifiers. James B. Machamer¹, Thomas Lloyd^1,2. 1) Dept of Neurology, JHMI, Baltimore, MD; 2) Dept of Neuroscience, JHMI, Baltimore, MD.

445A
Effects of nicotine on motor deficits and lifespan when given on different treatment days in a Parkinson's disease model. Mukul Mallick¹, Lori M. Buhlman¹, Gerald B. Call². 1) Biomedical Sciences, Midwestern University, Glendale, AZ; 2) Dept. of Pharmacology, Midwestern University, Glendale, AZ.

446B
Role of Transcriptional Co activator CREB Binding Protein in Amyloid Beta-42 (Aβ42) mediated neurodegeneration. Gregory F. Mancini, Meghana Tare, Amit Singh. Biology, University of Dayton, Dayton, OH.

447C
Study of the Regulation of Aggregates Formation by ALS associated SOD1 Mutations Using Drosophila. Michael Mccarthy^1,2,3,4, Dongsheng Chen^1,2,4, Zhihua Zhen^1,2,4, Antonio Tito^1,2,3,4, Zhen Xu^1,2,4, Yanning Rui^1,2,4, Sheng Zhang^1,2,3,4. 1) Center for Degenerative and Metabolic Disorders, Houston, TX; 2) Institute of Molecular Medicine, 1825 Pressler St., Houston, TX; 3) GSBS, Houston, TX; 4) UT-Houston, Houston, Texas.

448A
Determining the tissue basis of nicotine rescue in the Drosophila Parkinson’s Disease model. David O. Meyer¹, Lori M. Buhlman¹, Gerald B. Call². 1) Dept. of Biomedical Sciences, Midwestern University, Glendale, AZ; 2) Dept. of Pharmacology, Midwestern University, Glendale, AZ.

449B
Drosophila eye model to identify genetic modifiers of Aβ42 mediated neurodegeneration. Michael T. Moran, Oorvashi Roy Puli, Meghana Tare, Amit Singh. University of Dayton, Biology Department, 300 College Park Dayton, OH 45469.

450C
Investigating interactions of TDP-43 with the insulin pathway in a Drosophila model of amyotrophic lateral sclerosis. Andrés A. Morera¹, Taylor Podolsky¹, Alyssa Coyne², Archi Joardar¹, Daniela Zarnescu^1,3. 1) Department of Molecular and Cell Biology, University of Arizona, Tucson, AZ; 2) Department of Neuroscience, University of Arizona, Tucson, AZ; 3) Department of Neurology, University of Arizona, Tucson, AZ.

451A
Neurodegeneration in mitochondrial Complex III deficiency involves necrotic cell death. Francesco Napoletano, Diane Lebrun, Gilles Chatelain, Bertrand Mollereau. LBMC-Laboratory of molecular cell biology, ENS Ecole Normale Superieure de Lyon, Lyon, France.

452B
Drosophila cd Mutant of the Kynurenine Pathway as a Model for Dementia-Like Disorders. Ekatherina Nikitina, Yulia Dolgaya, Nadiya Utesheva, Elena Savvateeva-Popova. Dept Neurogenetics, Pavlov Inst Physiology, St Petersburg, Russian Federation.

453C
Glial involvement in neuronal synaptic bouton formation implicates pak3 and draper function. Emily F. Ozdowski, Nina T. Sherwood. Dept Biol, Duke Univ, Durham, NC.

454A
Identification of protective prion protein residues with flies: insights into the dog PrP-N158D substitution. Diego E. Rincon Limas¹, Jonatan Sanchez-Garcia¹, Yan Zhang¹, Joaquin Castilla², Pedro Fernandez-Funez¹. 1) Dept Neurology, University of Florida, Gainesville, FL; 2) CIC bioGUNE, Bizkaia, Spain.

455B
The influence of up-regulating basket in a Drosophila model of Machado-Joseph Disease. Catherine Romberger, John Warrick. University of Richmond, Department of Biology, Richmond, VA.

456C
Polar substitutions in helix 3 produce toxic, transmembrane isoforms of the Prion protein. Jonatan Sanchez-Garcia¹, Daniela Arbelaez¹, Kurt Jensen¹, Diego Rincon-Limas^1,3, Pedro Fernandez-Funez^1,2,3. 1) Department of Neurology, Univ of Florida, Gainesville, FL; 2) Department of Neuroscience, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32611, USA; 3) Genetics Institute and Center for Translational Research on Neurodegenerative Diseases, University of Florida, Gainesville, FL 32611, USA.

457A
Drosophila mth mutant resists paraquat induced Parkinson’s like symptoms. Arvind K. Shukla¹, Prakash Pragya¹, M.Z. Abdin², Debapratim Kar Chowdhuri¹. 1) Embryotoxicology, Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India; 2) Department of Biotechnology, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062.

458B
Search for the modifiers of amyloid-β-42 mediated cell death in Drosophila eye. Andrew Steffensmeier¹, Oorvashi Roy Puli², Meghana Tare², Madhuri Kango-Singh², Amit Singh². 1) Pre-Med, University of Dayton. 300 College Park Drive, Dayton, Ohio, 45469; 2) Department of Biology, University of Dayton. 300 College Park Drive, Dayton, Ohio, 45469.

459C
Identifying the molecular mechanism of nicotine-mediated rescue in a fly model of Parkinson's disease. Jared Techau¹, Gerald B. Call², Lori M. Buhlman¹. 1) Biomedical Sciences, Midwestern University, Glendale, AZ; 2) Dept. of Pharmacology, Midwestern University, Glendale, AZ.

460A
Study of the Intracellular Handling of Dopamine using Drosophila. Antonio Tito^1,2,3, Dongsheng Chen^1,3, Zhen Xu^1,3, Yanning Rui^1,3, Zhihua Chen^1,3, Sheng Zhang^1,2,3. 1) Center of Metabolic and Degenerative Diseases, IMM, Houston, TX; 2) Department of Neurobiology and Anatomy, GSBS, Houston, TX; 3) UT-HEALTH, Houston, TX.

461B
Molecular study of age-related hearing disorders using Drosophila. Leo Tsuda, Yasuhiro Omata, Yasutoyo Yamasaki, Young-Mi Lim. Animal Models of Aging, National Center for Geriatrics and Grontology, Aich, Japan.

462C
Vesicular trafficking in the pathogenesis of Parkinson’s disease. Katerina Venderova¹, Sarah Wong¹, Jieyun Cao¹, Radek Linhart¹, Melody Tran¹, Casey Ardrey¹, Christine Hsu¹, Anne Huynh¹, Jong Min Park¹, Brian Phi¹, Gina Stassinos¹, Edwin Yadidi¹, Matthew Seaman². 1) University of the Pacific, Stockton, CA; 2) University of Cambridge, Cambridge, UK.

463A
Buildup Arsenal for Functional Study of Huntingtin in Drosophila. Zhen Xu¹, Yanning Rui¹, Zhihua Chen¹, Dongsheng Chen¹, Antonio Tito¹, Yamin Sun¹, Sheng Zhang^1,2,3. 1) Center for Metabolic & Degenerative Diseases , the Brown Foundation Institute of Molecular Medicine; 2) the Graduate School of Biomedical Sciences (GSBS); 3) Department of Neurobiology and Anatomy, The University of Texas Health Science Center (UTHEALTH) at Houston.

464B
Characterizing the interaction of neuron and glia by electroretinogram. Po-An Yeh, Henry Sun. Molecular Biology, Taipei, Taiwan.

465C
RAF2 promotes the autophagic degradation of the Amyloid-β peptide. Yan Zhang¹, Diego Rincon-Limas¹, Pedro Fernandez-Funez^1,2. 1) Neurology, University of Florida, Gainesville, FL; 2) Neuroscience, University of Florida, Gainesville, FL.

466A
Drosophila as a model to study the genetic mechanisms of parental high-fat diet and its effects on the trans-generational initiation of obesity and heart dysfunction. Ryan Tyge Birse, Hannah Catan, Kathryn Reardon, Sean Oldham, Rolf Bodmer. Program of Development and Aging, Sanford-Burnham Medical Research Institute, La Jolla, CA.

467B
QTLs associated with female pupal weight on a high fat diet. Kelly Dew-Budd¹, Ronglin Che², Alison Motsinger-Reif², Laura Reed¹. 1) Department of Biological Sciences, University of Alabama, Tuscaloosa, AL; 2) Department of Statistics, North Carolina State University, Raleigh, NC.

468C
Myosin storage myopathy mutations cause age dependent muscle degeneration and cardiac dysfunction in a Drosophila model. Meera Cozhimuttam Viswanathan^1,2, William Kronert¹, Girish Melkani¹, Anthony Cammarato², Sanford Bernstein¹. 1) Department of Molecular Biology and SDSU heart institute. San Diego State Univ, San Diego, CA; 2) Johns Hopkins School of Medicine, Baltimore, MD.

469A
Altering the balance of prickle isoforms changes NMJ bouton morphology and predisposes flies to seizures by lowering the seizure threshold. Salleh Ehaideb¹, Katie Cranston¹, Atulya Iyengar¹, Atsushi Ueda¹, Alexander G. Bassuk², David Gubb³, Chun-Fang Wu¹, J. Robert Manak^1,2. 1) Dept of Biology, Univ of Iowa, Iowa City, IA; 2) Dept of Pediatrics, Univ of Iowa, Iowa City, IA; 3) CIC bioGUNE, Biscay Technology Park, Derio, Spain.

470B
Metformin reduces seizure-like activity in the Bang-sensitive paralytic mutants easily-shocked and technical knockout. Daniel R. Kuebler, Bryan Stone. Dept Biology, Franciscan University, Steubenville, OH.

471C
Development and Validation of an Aged Adult onset Alzheimer's Disease model in Drosophila melanogaster. Siddhita D. Mhatre, Sarah Michelson, Janine Gomes, Daniel Marenda. Department of Biology, Drexel University, Philadelphia, PA.

472A
Paraquat-induced Oxidative Stress in a Drosophila von Hippel Lindau Mutant. Anna Moyer, Marleshia Hall, Janis O'Donnell. Biological Sciences, University of Alabama, Tuscaloosa, AL.

473B
Modulators for Prominin and EYS function in photoreceptor morphogenesis. Jing Nie, Simpla Mahato, Andrew Zelhof. Biology, Indiana University Bloomington, Bloomington, IN.

474C
Drosophila heart as a model to study the genetic basis underlying Ischemia/Reperfusion (I/R)-induced cardiac injury: HIF1α and small HSPs. Sarah Piloto, Rolf Bodmer. Development and Aging, SBMRI, La Jolla, CA.

475A
Effects of Freeman Sheldon Syndrome Y583S and R672C Myosin Mutations on Indirect Flight Muscles of Drosophila. Deepti Rao, Anju Melkani, Sanford Bernstein. Department of Biology, San Diego State University, San Diego, CA.

476B
A genetically tractable model of noxious cold detection in Drosophila larvae. Heather Turner¹, Christian Landry², Michael Galko¹. 1) Biochemistry and Molecular Bio, MD Anderson, Houston, TX; 2) ProDev Engineering, Houston, TX.

477C
Establishing an in vivo functional analysis system for renal gene discovery in Drosophila pericardial nephrocytes. Fujian Zhang¹, Ying Zhao¹, Zhe Han^1,2. 1) Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, MI; 2) Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI.

478A
Dg-Dys-Syn1 signaling in Drosophila regulates stress related miRNA profile. Evgeniia V. Edeleva, April K. Marrone, Halyna R. Shcherbata. MPRG of Gene Expression and Signaling, Max Planck Institute, Goettingen, Germany.

Evolution and Quantitative Genetics

479B
Tests of Evolutionary Mechanisms for the Maintenance and Origin of Chromosomal Rearrangements in Drosophila pseudoobscura. Gwilym D. Haynes¹, Zachary L. Fuller¹, Ian S. Leopold¹, Atousa Janshahil¹, Shannon Duggan², Dianhuiz Zhu^2,3, Stephen Richards², Stephen W. Schaeffer¹. 1) Biology, The Pennsylvania State University, University Park, PA; 2) Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030; 3) Chevron, 1500 Louisiana St, Houston, Texas, 77002.

480C
Y chromosome variants tip the epigenetic balance. Bernardo Lemos, Alan Branco, John Gibbons, Cristina Valente. Molecular & Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA.

481A
Molecular Evolutionary Genetics of Mexican Chromosomal Rearrangements in Drosophila pseudoobscura. Ian S. Leopold, Stephen W. Schaeffer. Department of Biology, The Pennsylvania State University, University Park, PA.

482B
Differences in gene expression in Drosophila eye imaginal disc underlie morphological diversification. Isabel Almudi¹, Montserrat Torres², Saad Arif¹, Maria D. Santos Nunes¹, Maarten Hilbrant¹, Alistair McGregor¹, Nico Posnien². 1) Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom; 2) Georg-August-University Göttingen Johann-Friedrich-Blumenbach Institute for Zoology and Anthropology Department of Developmental Biology Ernst-Caspari-Hause (GZMB) Göttingen, Germany.

483C
Genetic and selective responses to artificial selection on wing shape. Jose D. Aponte, Ellen Kosman, Andres Plata Stapper, Zach Boudreau, Mollie Taylor, Lisa Hollensead, Karalyn Aronow, Don Levitan, David Houle. Biological Science, Florida State university, Tallahassee, FL.

484A
Intragenic epistasis underlying climatic adaptation in natural Drosophila populations. Emily L. Behrman¹, Alan O. Bergland², Dmitri Petrov², Paul S. Schmidt¹. 1) Biology, University of Pennsylvania, Philadelphia, PA; 2) Biology, Stanford University, Stanford, CA.

485B
Evidence of Blastoderm Dpp Gradient Conservation in Drosophila. Juan S. Chahda, Priscilla Ambrosi, Claudia M. Mizutani. Biology, Case Western Reserve University, Cleveland, OH.

486C
Investigating the Mechanism of Sex Determination in Branchinecta lindahli. Michael J. Colgan¹, Janice Krumm¹, Alexis Nagengast². 1) Department of Biology, Widener University, Chester, PA; 2) Department of Biochemistry and Chemistry, Widener University, Chester, PA.

487A
Evolution of a novel wing pigmentation pattern in Drosophila : when engrailed crosses the line. Héloïse D. Dufour, Cédric Finet, Shigeyuki Koshikawa, Jane E. Selegue, Sean B. Carroll. HHMI/UW Madison, Madison, WI.

488B
Cis-regulatory divergence at the Insulin Receptor locus contributes to evolution of a reproductive morphology between two Drosophila species. Delbert A. Green¹, Cassandra G. Exatavour². 1) Molecular and Cellular Biology, Harvard University, Cambridge, MA; 2) Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.

489C
Trans-generational medication in Drosophila sechellia. Balint Z. Kacsoh, Zachary R. Lynch, Nathan T. Mortimer, Todd A. Schlenke. Biology, Emory University, Atlanta, GA.

490A
A faster-X effect for gene expression in Drosophila embryos. Alex T. Kalinka¹, Melek A. Kayserili¹, Dave T. Gerrard², Pavel Tomancak¹. 1) Max Planck Institute, Dresden, Germany; 2) University of Manchester, Manchester, UK.

491B
Effects of extreme temperatures on embryonic development in Drosophila species from different climates. Steven G. Kuntz¹, Michael B. Eisen^1,2. 1) Department of Molecular and Cell Biology, University of California, Berkeley, CA; 2) Howard Hughes Medical Institute, University of California, Berkeley, CA.

492C
Divergence of the yellow trans-regulatory network plays a significant role in pigmentation diversity between species. Richard W. Lusk, Cassandra D. Kirkland, Gizem Kalay, Patricia J. Wittkopp. University of Michigan, Ann Arbor, MI.

493A
A dictionary of genetic effects as a unified representation of the genotype-phenotype map. Eladio J. Márquez¹, Rosa Moscarella¹, David Aponte¹, Washington Mio², David Houle¹. 1) Dept of Biological Science, Florida State University, Tallahassee, FL; 2) Dept of Mathematics, Florida State University, Tallahassee, FL.

494B
Convergent evolution of hybrid inviability in Drosophila. Daniel R. Matute¹, Jackie Gavin-Smyth². 1) Human Genetics, Univ Chicago, Chicago, IL; 2) Ecology and Evolution, Univ Chicago, Chicago, IL.

495C
Genetic analysis of differences in eye and face morphology between Drosophila simulans and Drosophila mauritiana. Alistair P. McGregor¹, Saad Arif¹, Maarten Hilbrant¹, Corinna Hopfen^2,3, Isabel Almudi¹, Maria D. S. Nunes¹, Nico Posnien^1,4, Linta Kuncheria¹, Kentaro Tanaka⁵, Philipp Mitteroecker⁶, Christian Schötterer². 1) Oxford Brookes University, Oxford, United Kingdom; 2) Institute for Population Genetics, Vetmeduni Vienna, Vienna, Austria; 3) Max Planck Institute for Biology of Ageing, Cologne, Germany; 4) Department of Developmental Biology, Georg August University, Göttingen; 5) Department of Population Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan; 6) Department of Theoretical Biology, University of Vienna, Vienna, Austria.

496A
Diversity and dynamics of chorion patterning across Drosophila species. Matthew G. Niepielko, Robert A. Marmion, Kenneth Kim, David Luor, Chelsea E. Ray, Nir Yakoby. Center for Computational and Integrative Biology, Rutgers University, Camden, NJ.

497B
Evolution of clasper morphology between Drosophila simulans and D. mauritiana. Maria D. S. Nunes¹, Kentaro Tanaka¹, Corinna Hopfen^2,3, Christian Schlötterer², Alistair P. McGregor¹. 1) BMS, Oxford Brookes University, Oxford, United Kingdom; 2) Institute for Population Genetics, Vetmeduni, Vienna, Austria; 3) Max Planck Institute for Biology of Ageing, Cologne, Germany.

498C
Septin evolution following gene duplication. Ryan S. O'Neill, Denise V. Clark. Biology, University of New Brunswick, Fredericton, New Brunswick, Canada.

499A
A role for male genitalia in mate recognition: Aedeagus shape evolution results in pseudocopulation in the Drosophila mojavensis species cluster. Maxi Polihronakis Richmond, Therese Markow. Cell and Developmental Biology, University of California, San Diego, La Jolla, CA.

500B
Measuring the effects and rates of microsatellite instability in the morphogen concentration-sensitive enhancers of Drosophila. Clinton Rice, Albert J. Erives. Department of Biology, University of Iowa, Iowa City, IA.

501C
The evolution and development of limb regeneration: a perspective from studies on the red flour beetle, Tribolium castaneum. Yuichiro Suzuki. Department of Biological Sciences, Wellesley College, Wellesley, MA.

502A
Chill coma recovery analysis a major climatic adaptation tool among drosophila species. Pankaj K. Tyagi¹, Shruti Tyagi¹, Sudhir Singh². 1) Dept Biotechnology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India; 2) Department of Biotechnology, NIMS University, Jaipur Rajesthan INDIA.

503B
Regulation of wingless by Abd-B and Doublesex and the evolution of male abdominal segment reduction in Drosophila. Wei Wang, John Yoder. Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL.

504C
Regulation of Diverse Modes of Segmentation in Coleoptera (Beetles). Jie Xiang¹, Alison Heffer¹, Leslie Pick^1,2. 1) Program in Molecular & Cell Biology, University of Maryland, College Park, MD; 2) Department of Entomology, University of Maryland, College Park, MD.

505A
Inbreeding reveals mode of past selection: stabilizing selection for sperm length but directional selection for sperm competition success and male attractiveness in Drosophila melanogaster. Outi Ala-Honkola^1,2, David Hosken³, Mollie Manier², Stefan Lüpold², Elizabeth Droge-Young², Kirstin Berben², William Collins², John Belote², Scott Pitnick². 1) Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland; 2) Department of Biology, Syracuse University, Syracuse, NY, USA 13244; 3) Centre for Ecology and Conservation, College of Life and Environmental Sciences, University of Exeter, UK.

506B
Opposing fitness effects contribute to maintenance of polymorphism at a QTN in Aldehyde dehydrogenase. Mahul Chakraborty, James Fry. Department of Biology, University of Rochester, Rochester, NY.

507C
Sperm utilization and fertility of mitochondrial introgression genotypes in Drosophila. James A. Mossman, David M. Rand. Ecology and Evolutionary Biology, Brown University, Providence, RI.

508A
Viability in strains of Drosophila melanogaster submitted to artificial selection for wing shape divergence. Libéria Torquato, Blanche Bitner-Mathé. UFRJ, Rio de Janeiro, Brazil.

509B
Purging of deleterious mutations through sexual selection: negative evidence. Jing Zhu, James Fry. Biology Dept, University of Rochester, Rochester, NY.

510C
The Drosophila Early Ovarian Transcriptome Provides Insight to the Molecular Causes of Recombination Rate Variation. Andrew Adrian^1,2, Josep Comeron^1,3. 1) Biology, University of Iowa, Iowa City, IA; 2) Interdisciplinary Graduate Program in Informatics, University of Iowa, IA; 3) Interdisiplinary Program in Genetics, University of Iowa, IA.

511A
Variability of 5' and 3' untranslated regions of Dras1 gene in the Drosophila virilis species group. Anna I. Chekunova¹, Prokhor A. Proshakov¹, Maxim I. Barsukov¹, Ekaterina Sivoplyas¹, George N. Bachtojarov², Svetlana Yu. Sorokina¹, Vladimir G. Mitrofanov¹. 1) Dept Genetics, Koltsov Inst Dev Biol, RAS, Moscow, Russian Federation; 2) Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow, Russian Federation.

512B
Extended open reading frames in Drosophila associated with small introns are a useful genomic tool for the identification of rapidly evolving coding sequence and splice junctions. Robert C. Eisman, Thomas C. Kaufman. Dept Biol, Jordan Hall A505, Indiana Univ, Bloomington, IN.

513C
Evolution of a heterochromatic domain, the Muller F element, in Drosophila / Sophophora. SCR Elgin¹, M. Burg², J. DiAngelo³, A. Haberman⁴, C. Jones⁵, L. Kadlec⁶, SCS Key⁷, J. Leatherman⁸, GP McNeil⁹, H. Mistry¹⁰, A. Nagengast¹⁰, DW Paetkau¹¹, S. Parrish¹², L. Reed¹³, S. Schroeder¹⁴, S. Smith¹⁵, M. Wawersik¹⁶, L. Zhou¹⁷, CD Shaffer¹, W. Leung¹. 1) Washington U MO; 2) Grand Valley St MI; 3) Hofstra U NY; 4) Oberlin OH; 5) Moravian PA; 6) Wilkes U PA; 7) NC Central U NC; 8) Northern Colorado CO; 9) York/CUNY NY; 10) Widener U PA; 11) St Mary's IN; 12) McDaniel MD; 13) Alabama-Tuscaloosa AL; 14) Webster U MO; 15) Arcadia U PA; 16) William & Mary VA; 17) U Pittsburgh PA.

514A
Evolution of piRNA clusters in Anopheles gambiae M and S forms. Phillip George¹, Igor Sharakhov¹, Chantal Vaury², Silke Jensen². 1) Department of Entomology, Virginia Tech, Blacksburg, VA, USA; 2) Laboratoire Génétique, Reproduction et Développement (GReD), Clermont-Ferrand, France.

515B
Young retrogene detection in Drosophila. Tatiana A. Gurbich¹, JJ Emerson², Doris Bachtrog¹. 1) Integrative Biology, University of California, Berkeley, Berkeley, CA; 2) Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA.

516C
Lack of association between piRNA abundance and the deleterious capacity of transposable element families in Drosophila melanogaster. Erin S. Kelleher, Daniel A. Barbash. Molecular Biology and Genetics, Cornell University, Ithaca, NY.

517A
Evolutionary Constraints on DNA Shape. Tevfik H. Kitapci, Tianyin Zhou, Remo Rohs, Sergey V. Nuzhdin. University of Southern California, Los Angeles, CA.

518B
Rapid evolution of the Responder satellite in the melanogaster species subgroup. Amanda M. Larracuente, Daven C. Presgraves. Biology, University of Rochester, Rochester, NY.

519C
The functional and evolutionary significance of nested genes. Grace Y. C. Lee¹, Hsiao-Han Chang². 1) Ecology and Evolution, University of Chicago, Chicago, IL; 2) Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.

520A
Candidate genes contribute to behavioral isolation revealed by comparative genomic approach. Juan Li¹, Lan Jiang¹, Chung-I Wu^1,2, Chau-Ti Ting³, Xuemei Lu¹. 1) Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, People’s Republic of China; 2) Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637; 3) Department of Life Science, Institute of Ecology and Evolutionary Biology, & Institute of Zoology, National Taiwan University, Taipei, Taiwan, ROC.

521B
Sex-specific embryonic gene expression at different stages of sex chromosome evolution. Susan E. Lott^1,4, Jacqueline E. Villalta², Doris Bachtrog³, Michael B. Eisen^1,2,3. 1) Dept. of Molecular and Cell Biology; 2) Howard Hughes Medical Institute; 3) Dept. of Integrative Biology, University of California, Berkeley, CA; 4) Dept. of Evolution and Ecology, University of California, Davis, CA.

522C
Rapid evolution and differential expression of transcripts associated with sex chromosome meiotic drive in stalk-eyed flies. Josephine A. Reinhardt¹, Richard H. Baker², Gerald S. Wilkinson¹. 1) Biology, University of Maryland College Park, College Park, MD; 2) Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY.

523A
Copy number variation and the limits of natural seleciton in Drosophila yakuba and Drosophila simulans. Rebekah L. Rogers¹, Julie M. Cridland², Ling Shao¹, Kevin R. Thornton¹. 1) Ecology and Evolutionary Biology, University of California, Irvine, CA; 2) Department Of Evolution and Ecology, University of California, Davis, CA.

524B
The short life cycle of orphan genes in the Drosophila obscura group explains the paradox of conserved gene number across species. Christian W. Schloetterer, Nicola Palmieri, Carolin Kosiol, Viola Nolte. Inst f Populationsgenetik, Vetmeduni Vienna, Wien, Austria.

525C
Transfer of mitochondrial DNA fragments into the nuclear genome in flies and cell line of D.virilis. Svetlana Y. Sorokina¹, Denis A. Romanov², Boris V. Andrianov², Ilya A. Zakharov². 1) Dept Genetics, Koltsov Inst Dev Biology, Moscow, Russian Federation; 2) Dept insect Genetics, Vavilov Inst Gen Genet, Moscow, Russian Federation.

526A
Selection driven signatures of domestication in Drosophila. Craig E. Stanley, Rob J. Kulathinal. Dept. of Biology, Temple University, Philadelphia, PA.

527B
Identifying misregulated genes contributing to male lethality in D. melanogaster/D. simulans hybrids with RNA-seq. Kevin HC Wei, Andrew G. Clark, Daniel A. Barbash. Molecular Biology and Genetics, Cornell, Ithaca, NY.

528C
Sex-Specific Adaptation Drives Early Sex Chromosome Evolution in Drosophila. Qi Zhou, Doris Bachtrog. Integrative Biology, University of California, Berkeley, Berkeley, CA.

529A
Patterns of gene co-expression evolution throughout development in the Drosophila pseudoobscura group. Kawther Abdilleh, Carlos Machado. Department of Biology, Univ Maryland, College Park, MD.

530B
Parthenogenesis as an alternative reproductive strategy in Drosophila. Chia-chen Chang¹, Shu Fang², Chau-Ti Ting³, Hwei-yu Chang^1,2. 1) Department of Entomology, National Taiwan University, Taipei, Taiwan 10617, ROC; 2) Biodiversity Research Center, Academia Sinica, Taipei, Taiwan 11529, ROC; 3) Department of Life Science, Genome and Systems Biology Degree Program, Institute of Ecology and Evolutionary Biology, Institute of Zoology, and Research Center for Developmental Biology and Regeneration Medicine, National Taiwan University, Taipei, Taiwan.

531C
Sexually attractive traits as activity indicators of nutrient-sensing pathways. Tatyana Y. Fedina¹, Tsung-Han Kuo², Ingrid Hansen², Klaus Dreisewerd³, Herman A. Dierick², Joanne Y. Yew⁴, Scott D. Pletcher^1,2. 1) University of Michigan, USA; 2) Baylor College of Medicine, USA; 3) University of Münster, Germany; 4) National University of Singapore, Singapore.

532A
Epistasis plays a dominant role in the genetic architecture of Drosophila quantitative traits. Wen Huang¹, Robert Anholt², Trudy Mackay¹. 1) Department of Genetics, North Carolina State University, Raleigh, NC; 2) Department of Biology, North Carolina State University, Raleigh, NC.

533B
The effects of thermal stress on embryonic development: from cellular defects to whole-organism survival. Brent L. Lockwood, Kristi L. Montooth. Department of Biology, Indiana University, Bloomington, IN.

534C
Evolution of behavioral defenses against parasitoid wasps in the melanogaster subgroup. Zachary Lynch, Balint Kacsoh, Todd Schlenke. Biology Department, Emory University, 1510 Clifton Rd, Atlanta, GA 30322.

535A
Elucidation of the sex-determination pathways in an organism with monogenic sex determination. Meaghan L. Pimsler¹, Sing-Hoi Sze², Corbin D. Jones³, Jeffery K. Tomberlin¹, Aaron M. Tarone¹. 1) Entomology, TAMU, College Station, TX; 2) Computer Science and Engineering, TAMU, College Station, TX; 3) Biology Department, UNC, Chapel Hill, NC.

536B
Cis-regulatory determinants of Y-linked gene expression variation. Timothy Sackton, Jun Zhou, Daniel Hartl. Organismic & Evol Bio, Harvard Univ, Cambridge, MA.

537C
A genetic and molecular analysis of mating choice in D. simulans. Rui Sousa-Neves, Youngmin Chu, Emma Yang, Joseph Schinaman, Sebastian Chahda. Biol, Case Western Reserve Univ, Cleveland, OH.

538A
The effect of sex-ratio meiotic drive on sequence evolution and gene expression in Drosophila affinis. Robert Unckless, Andrew Clark. Department of Entomology, Cornell University, Ithaca, NY.

539B
Dissecting the sources of genetic variation in regulation of gene expression within D. simulans isolates. Hosseinali Asgharian¹, Rita M. Graze², Bradley J. Main¹, Marta L. Wayne², Alison M. Morse², Lauren M. McIntyre², Sergey V. Nuzhdin¹. 1) Molecular and Computational Biology, University of Southern California, Los Angeles, CA; 2) Molecular Genetics and Microbiology, University of Florida, Gainesville, FL.

540C
The evolutionary consequences of seasonality: assessing demography and balancing selection in real time. Alan O. Bergland¹, Emily Behrman², Katherine O'Brien², Paul Schmidt², Dmitri A. Petrov¹. 1) Dept. of Biol., Stanford Univ, Stanford, CA; 2) Dept. of Biol., Univ. of Penn., Philadelphia, PA.

541A
Evidence of positive selection on sex biased genes in Drosophila melanogaster. Joseph R. Boland, Matthew E. B. Hansen, Craig E. Stanley, Jr., Rob J. Kulathinal. Department of Biology, Temple University, Philadelphia, PA.

542B
How looks like Drosophila in different Romanian ecosystems. Gallia A. Butnaru¹, Cristina Chelu², Cristina Popescu³. 1) Prof. Dept of Genetics, Banat Univ of Agricultural Sci ences and Veterinary Medicine from Timisoara, Romania; 2) Ingenuity Systems Inc., Redwood City, California, Romanian Branch; 3) West University “Vasile Goldis” from Arad, Romania.

543C
Constraints on the evolution of plasticity in Drosophila melanogaster. Brandon S. Cooper¹, Loubna A. Hammad², Kristi L. Montooth¹. 1) Department of Biology, Indiana University, Bloomington, IN; 2) METACyt Biochemical Analysis Center, Department of Chemistry, Indiana University, Bloomington, IN.

544A
Genomic basis of latitudinal differentiation among North American populations of Drosophila melanogaster. Thomas Flatt^1,2, Daniel K. Fabian², Martin Kapun², Viola Nolte², Robert Kofler², Paul S. Schmidt³, Christian Schlötterer². 1) Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland; 2) Institut für Populationsgenetik, Vetmeduni Vienna, Vienna, Austria; 3) Department of Biology, University of Pennsylvania, Philadelphia.

545B
Do Males Matter? Exploring Male-Mediated Effects on Female Meiotic Recombination. Chad M. Hunter, Nadia Singh. Department of Genetics, North Carolina State University, Raleigh, NC 27695.

546C
Identifying natural genetic variation for Drosophila melanogaster resistance to parasitoid wasp infection. Kate J. Hutchence, Todd A. Schlenke. Biology Department, Emory University, Atlanta, GA.

547A
Variation in gene expression during embryogenesis in Drosophila strains and species. Asli Kayserili, Alex Kalinka, Pavel Tomancak. Max Planck Institute for Cell Biology and Genetics Pfotenhauerstrasse 108, Dresden, Germany.

548B
Natural genetic variation in chromatin state assessed by Position Effect Variegation. Keegan J. Kelsey, Andrew G. Clark. Molecular Biology and Genetics, Cornell University, Ithaca, NY.

549C
Fruit flies prophylactically medicate offspring after seeing parasites. Todd A. Schlenke, Balint Z. Kacsoh, Zachary R. Lynch, Nathan T. Mortimer. Biol/O Wayne Rollins Res Ctr, Emory Univ, Atlanta, GA.

550A
Experimental evolution in Drosophila uncovers the importance of phenotypic plasticity and canalization for the evolution of gene expression in a changed environment. Christian W. Schloetterer¹, Miguel Gallach^1,2, Viola Nolte¹, Pablo Orozco-TerWengel^1,3, Eszter Ari¹. 1) Inst f Populationsgenetik, Vetmeduni Vienna, Wien, Austria; 2) present address: Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna and Medical University of Vienna. Vienna, Austria; 3) present address: Cardiff University, Wales, UK.

551B
Genome-wide fine-scale recombination rate variation in Drosophila melanogaster. Yun S. Song^1,2, Andrew Chan¹, Paul Jenkins³. 1) Department of EECS, University of California, Berkeley, CA, USA; 2) Department of Statistics, University of California, Berkeley, CA, USA; 3) Department of Statistics, University of Warwick, Coventry, UK.

552C
The genetic architecture of diet-dependent immune defense in Drosophila. Robert Unckless, Susan Rottschaefer, Brian Lazzaro. Department of Entomology, Cornell University, Ithaca, NY.

553A
Variation at the Cyp6g1 locus between two populations of Drosophila Melanogaster. Srna Vlaho, Matthew Salomon, Sergey Nuzhdin, Daniel Campo. MOLECULAR AND COMPUTATIONAL BIOL, UNIVERSITY OF SOUTHERN CALIFORNI, LOS ANGELES, CA.

554B
An extreme test of mutational meltdown in small populations. Ronny C. Woodruff. Dept Biological Sciences, Bowling Green State Univ, Bowling Green, OH.

555C
Molecular Evolution of the Synaptonemal Complex in the genus Drosophila. Lucas Hemmer, Justin Blumenstiel. Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS.

556A
Intragenomic conflict drives rapid evolution of piRNA pathway genes in Drosophila. Jeffrey P. Vedanayagam, Daniel Garrigan. Department of Biology, University of Rochester, Rochester, NY.

557B
Using Experimental Evolution to Study Temporal Responses of the Genome to Selection. Julien F. Ayroles^1,2, Lawrence G. Harshman³, Jennifer Grenier², Andrew G. Clark². 1) OEB, Harvard, Cambridge, MA; 2) MBG, Cornell, Ithaca, NY; 3) School of Biological Sciences, Univ. of Nebraska, Lincoln, NE.

558C
Adaptive trait dissection in non-model Drosophila: Using next-gen sequencing to fine-map a naturally-occurring polymorphism in the sexually-selected cuticular hydrocarbons of D. serrata. Stephen F. Chenoweth, Bosco Rusuwa, Francesca Frentiu. Biological Sciences, University of Queensland, Brisbane, Queensland, Australia.

559A
Genetic basis of natural variation in cuticular hydrocarbons in the Drosophila melanogaster Genetic Reference Panel. Lauren Dembeck^1,3, Katalin Böröczky^2,3, Michael Maguire^1,3, Richard Lyman¹, Coby Schal^2,3, Trudy Mackay^1,2,3. 1) Department of Genetics, North Carolina State University, Raleigh, NC; 2) Department of Entomology, North Carolina State University, Raleigh, NC; 3) W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC.

560B
A genome-wide association approach to characterize natural genetic variation in the plastic response of mated lifespan and age-specific fecundity to diet in Drosophila melanogaster. Mary F. Durham¹, Michael M. Magwire², Jeff Leips¹. 1) Dept Biological Sci, Univ Maryland, Baltimore County, Baltimore, MD; 2) Department of Genetics, N.C. State University, Raleigh, NC.

561C
Building a better mousetrap: High-throughput, high-parameter analysis of Drosophila aggression gives novel insight into the genetic architecture of behavior. Bryn E. Gaertner, Landon Blakey, Kirsty Ward, Trudy F. C. Mackay. Genetics, North Carolina State University, Raleigh, NC.

562A
Understanding the effects of Insecticides using Genome-Wide Association Studies. Llewellyn Green^1,2, Josh Schmidt^1,2, Bec Smith^1,2, Paul Battlay^1,2, Charles Robin^1,2. 1) Genetics, The University of Melbourne, Melbourne, Victoria, Australia; 2) The Bio21 Institute, Melbourne, Victoria, Australia.

563B
Bayesian multi-phenotype genome-wide association for structured experimental designs. Anthony J. Greenberg^1,2, Gabriel E. Hoffman¹, Pavel Korniliev¹, Yuxin Shi¹, Susan McCouch², Jean-Luc Jannink², Jason Mezey¹. 1) Dept BSCB, Cornell Univ, Ithaca, NY; 2) Dept PBG, Cornell Univ, Ithaca, NY.

564C
Sperm length predicts female sperm loads in Drosophila species in the wild. Hiroto Kameyama¹, Esra Durmaz², Giovanni Hanna¹, Therese Markow¹. 1) University of California, San Diego, Division of Biological Sciences, 9500 Gilman Dr., La Jolla, CA 92093; 2) Hacettepe University, Faculty of Science, Department of Biology, 06800 Cankaya, Ankara / TURKEY.

565A
Genetic dissection of genomewide expression variation in the Drosophila female brain. Elizabeth G. King¹, B. Sanderson², Casey L. McNeil², Anthony D. Long¹, Stuart J. Macdonald². 1) Ecology & Evolutionary Biology, UC Irvine, Irvine, CA; 2) Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, Kansas 66045.

566B
Developmental noise and evolution of a new stable bristle pattern in D. santomea. Virginie Orgogozo¹, Isabelle Nuez¹, Amir Yassin¹, Daniel Matute², David Stern³, Jean David¹. 1) Institut Jacques Monod, CNRS UMR7592, Paris, France; 2) University of Chicago, Chicago, USA; 3) Janelia Farm, Ashburn, USA.

567C
Mitochondrial genotypes drive differential expression of nuclear genes under varied levels of hypoxia in Drosophila. David M. Rand, Yawei Ge, Nicholas Jourjine, Patrick Flight. Ecology & Evolution, Brown Univ, Providence, RI.

568A
Verification of single nucleotide polymorphisms affecting sleep in Drosophila. Yazmin L. Serrano, Susan T. Harbison. Laboratory of Systems Genetics, National Heart Lung and Blood Institute, Bethesda, MD.

569B
Genetic and plastic effects for body melanisation in cold adapted - D. takahashii. Shama Singh. ZOOLOGY, UNIVERSITY OF DELHI, DELHI, India.

570C
Epistatic interactions are prevalent in Drosophila 3’UTR evolution. Ying Zhen, Peter Andolfatto. Ecology and Evolutionary Biology, Princeton University, Princeton, NJ.

571A
Assaying functional divergence in the hybrid incompatibility gene Hybrid male rescue (Hmr) between D. melanogaster and D. simulans. Tawny N. Cuykendall, Daniel A. Barbash. Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY.

572B
Natural selection acts across species boundaries in Drosophila simulans and D. sechellia. Daniel Garrigan, Sarah Kingan, Cara Brand. Department of Biology, University of Rochester, Rochester, NY.

573C
Nuclear introgression in Drosophila subobscura and D. madeirensis despite distinct mitochondrial genomes. Danielle Herrig¹, Ana Llopart¹. 143 Biology Building University of Iowa, Iowa City, IA.

574A
Formation of reproductive barriers in a hybrid zone of American and Caribbean Drosophila melanogaster. Joyce Kao, Sergey Nuzhdin. University of Southern California, Los Angeles, CA.

575B
Patterns of divergence reveal genomic “islands of speciation” in young semispecies of Drosophila athabasca. Karen M. Wong Miller¹, Michael B. Eisen^2,3, Doris Bachtrog¹. 1) Department of Integrative Biology, University of California, Berkeley, CA; 2) Department of Molecular and Cell Biology, University of California, Berkeley, CA; 3) Howard Hughes Medical Institute, University of California, Berkeley, CA.

576C
The hybrid incompatibility gene Lhr represses repetitive elements. Satyaki P. Rajavasireddy, Shuqing Ji, Daniel A. Barbash. Molecular Biology and Genetics, Cornell University, Ithaca, NY.

577A
Transgenerational effects on Drosophila melanogaster populations detected after specific environmental changes. Patricia Ramos-Morales, Adriana MuÑoz, Blanca R. Hernandez, Hugo Rivas, Armando MuÑoz. FACULTAD DE CIENCIAS, UNAM, MEXICO.

Immunity and Pathogenesis

578B
JAK/Stat signaling in the D. melanogaster cellular immune response. Susanna E. Brantley, Nathan Mortimer, Todd Schlenke. Biology, Emory University, Atlanta, GA.

579C
Variation in fly transcriptional responses after infection by diverse endoparasitoid wasp species. Lindsey C. Fallis, Todd A. Schlenke. Biology Department, Emory University, Atlanta, GA.

580A
A role for nematocytes in the cellular immune response of the Drosophilid Zaprionus indianus. Balint Z. Kacsoh, Julianna Bozler, Todd A. Schlenke. Biology, Emory University, Atlanta, GA.

581B
Extracellular matrix-modulated FGF signaling in Drosophila blood progenitors regulates their differentiation via a ras/ETS/FOG pathway and TORC1 function
. Julian A. Martinez-Agosto, Michelle Dragojlovic-Munther. Department of Human Genetics, University of California Los Angeles, Los Angeles, CA.

582C
Immune self recognition in Drosophila: tuSz mutants exhibit an aberrant self-directed immune response. Nathan T. Mortimer, Todd A. Schlenke. Department of Biology, Emory University, Atlanta, GA.

583A
The role of hemocytes in the control of viral replication and disease in vivo. Javier Robalino, Louisa Wu. Institute for Bioscience and Biotechnology Research, Dept. of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742.

584B
RpS6 is a substrate of PALLBEARER and a negative regulator of apoptotic cell clearance in Drosophila. Hui Xiao, Nathalie Franc. The Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA.

585C
Production and Verification of Drosophila melanogaster Nora virus Monospecific Antisera. Morgan Caron Abert, Brad L. Ericson, Darby J. Carlson, Kimberly A. Carlson. Biology, University of Nebraska at Kearney, Kearney, NE.

586A
The Larval Clot and Immune Defense. Clara I. Bajzek, Mitchell S. Dushay. BCHS, Illinois Institute of Technology, Chicago, Il.

587B
Route of Nora virus transmission in Drosophila melanogaster. Justin L. Buchanan, Brad L. Ericson, Darby J. Carlson, Kimberly A. Carlson. Biology Department, University of Nebraska at Kearney, Kearney, NE.

588C
RNA-Seq analysis of the Drosophila transcriptome in response to infection by entomopathogenic nematodes and their mutualistic bacteria. Julio C. Castillo, Ioannis Eleftherianos. The George Washington University, Department of Biological Sciences, Washington, DC 20052.

589A
Severity of chronic infections depends on the amount of dietary sugar. Moria C. Chambers, Chloe Ota, Ilana Porges, Brian P. Lazzaro. Entomology, Cornell University, Ithaca, NY.

590B
Neural primordium as a target of Spiroplasma-induced male killing in Drosophila melanogaster. Trisha N. Chong, Jennifer C. Martin, Patrick M. Ferree. W. M. Keck Science Department, The Claremont Colleges, Claremont, CA.

591C
Regulation of energetic metabolism by adenosine during parasitic wasp infection. Tomas Dolezal^1,2, Adam Bajgar², Katerina Kucerova². 1) Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA; 2) Department of Molecular Biology, Faculty of Science, University of South Bohemia in Ceske Budejovice, Czech Republic.

592A
Sex-specific immune response against bacterial infection. David Duneau, Brian Lazzaro. Entomology, Cornell university, Ithaca, NY.

593B
Characterization of an anti-wasp response gene in Drosophila. Erin S. Keebaugh, Todd A. Schlenke. Dept Biol, Emory Univ, Altanta, GA.

594C
Evaluation of a Yeast Expression System to Direct Assembly of the Drosophila melanogaster Nora virus. Kellie D. Licking-Murray, Brad L. Ericson, Darby J. Carlson, Kimberly A. Carlson. Biology, University of Nebraska at Kearney, Kearney, NE.

595A
Identification of Drosophila genes involved in recovery from infection using an inducible RNAi system. Karla L. Lightfield, David S. Schneider. Microgiology and Immunology, Stanford University, Stanford, CA.

596B
Identification of recovery mechanisms from infection. Alexander Louie, David Schneider. Microbiology and Immunology, Stanford University, Stanford, CA.

597C
Antiviral Autophagy in Drosophila. Jerome M. Molleston, Ryan H. Moy, Beth Gold, Sara Cherry. Microbiology, Penn Genome Frontiers Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

598A
Role of Nora virus VP3 protein in Drosophila melanogaster infection. Sajna Anand Sadanandan¹, Jens-Ola EkstrÖm¹, Dan Hultmark^1,2. 1) DEPARTMENT OF MOLECULAR BIOLOGY, UMEÅ UNIVERSITY, UMEÅ, SWEDEN; 2) INSTITUE OF BIOMEDICAL TECHNOLOGY, UNIVERSITY OF TAMPERE, TAMPERE, FINLAND.

599B
Identification of Pseudomonas aeruginosa virulence factors in a Drosophila melanogaster intestinal infection model. Samantha Haller, Ferrandon Dominique. UPR9022 , CNRS, Université de Strasbourg, IBMC, Strasbourg, France.

600C
Elucidating the mechanistic basis for the trade-off between reproduction and immunity in female D. melanogaster. Robin A. Schwenke, Brian P. Lazzaro. Cornell University, Ithaca, NY.

601A
Effects of host diet on the tradeoff between mating and immunity in Drosophila melanogaster. Parvin Shahrestani, Brian Lazzaro. Entomology, Cornell University, Ithaca, NY.

602B
Role of Thioester-containing proteins in the immune response of Drosophila against entomopathogenic nematodes and their mutualistic bacteria. Upasana Shokal, Ioannis Eletherianos. Department of Biological Sciences, George Washington University, Washington, DC.

603C
Identification and characterization of the novel antiviral gene rogue in Drosophila melanogaster. Jessica Tang^1,2, Anne Macgregor^1,3, Louisa Wu^1,3. 1) Institute for Bioscience and Biotechnology Research,; 2) Molecular and Cell Biology Graduate Program,; 3) Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD.

604A
Rapid spread of Spiroplasma defensive endosymbionts in Drosophila hydei under high parasitoid wasp pressure. Jialei Xie, Lauryn Winter, Caitlyn Winter, Mariana Mateos. Wildlife and Fisheries Sciences, Texas A&M University, College Station, TX.

605B
Regulation of Drosophila innate immune signaling by amyloids and phospholipids. Anni Kleino¹, Jixi Li², Johanna Napetschnig², Lucy Chai¹, Kingsley Essien¹, Hao Wu², Neal Silverman¹. 1) Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA; 2) Program in Cellular and Molecular Medicine, Children's Hospital Boston, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

606C
Drosophila as a model organism to understand infection tolerance mechanisms. Victoria Allen, Reed O'Connor, Clarice Zhou, Vanessa Hill, Elizabeth Stone-Jacobs, Thomas McCord, Michelle Shirasu-Hiza. Genetics and Development, Columbia University Medical Center, New York, NY.

607A
Big bang and septate junctions modulates gut immune tolerance in Drosophila. François Bonnay¹, Eva Cohen-Berros¹, Gabrielle L. Boulianne², Jules A. Hoffmann¹, Nicolas Matt¹, Jean-Marc Reichhart¹. 1) UPR9022, CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France; 2) Programme in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.

608B
Investigating the allelic determinants of immunological natural variation in Drosophila melanogaster. Alejandra Guzman, David Schneider. Microbiology and Immunology, Stanford University, Stanford, CA.

609C
Infection Susceptibility in a TPI Deficiency Model. Natasha C. Hardina¹, Carolyn Steglich¹, Stacy L. Hrizo^1,2. 1) Biology , Slippery Rock University, Slippery Rock, PA; 2) Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

610A
Diedel, induced by NF-kB pathway, regulates tolerance during Sindbis infection. Olivier Lamiable¹, Cordula Kemp¹, Friedemann Weber², Laurent Troxler¹, Nadege Pelte^3,4, Michael Boutros⁴, Charles Hetru¹, Jean-Luc Imler¹. 1) Institut de Biologie Moléculaire et Cellulaire CNRS UPR9022, Strasbourg, France; 2) Institut für Medizinische Mikrobiologie und Hygiene, Freiburg, Germany; 3) Donnelly Centre for Cellular and Biomolecular research, Toronto, Canada; 4) Department of Cell and Molecular Biology, Heidelberg University, Heidelberg, Germany.

611B
Ingestion of Pseudomonas fluorescens Pf-5 by Drosophila melanogaster causes larval immune response dependent on bacterial media type. Kristin L. Latham, Amy Nicholson, Jenna Schneider, Elizabeth Mason. Biology, Western Oregon Univ, Monmouth, OR.

612C
Analysis of a novel antibacterial protein, Noduler that is conserved in insects and mammals. Asha Minz, Javaregowda Nagaraju. Laboratory of Molecular Genetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Andhra Pradesh, India.

613A
Identification of Transcriptionally Induced Antiviral Effectors in Drosophila. Gregory Osborn¹, Jie Xu¹, Ari Yasunaga¹, Ian Lamborn², Beth Gordesky-Gold¹, Sara Cherry¹. 1) Department of Microbiology, University of Pennsylvania, Philadelphia, PA; 2) Department of Immunology, University of Pennsylvania, Philadelphia, PA.

614B
Cr(VI) induced suppression of Drosophila cellular immune response: protection by sod overexpression. Pragya Prakash¹, Arvind Shukla¹, M.Z. Abdin², Debapratim Kar Chowdhuri¹. 1) Embryotoxicology, CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India; 2) Department of Biotechnology, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062.

615C
Characterisation of lipid-mediated inflammatory pathways in Drosophila. Mark A. Watson¹, Karen Massey², Soyeon Kwon¹, Anna Nicolaou², Paul Badenhorst¹. 1) Institute of Biomedical Research, University of Birmingham, Edgbaston B15 2TT, UK; 2) Bradford School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK.

616A
Bacterial diversity associated with Drosophila in the laboratory and in the natural environment. Fabian Staubach¹, John Baines², Sven Kuenzel², Elisabeth Bik³, Dmitri Petrov¹. 1) Biology, Stanford University, Stanford, CA; 2) Max Planck Institute for Evolutionary Biology, Plön, Germany,; 3) Department of Microbiology & Immunology, Stanford School of Medicine, Stanford, California, United States of America.

617B
Mechanisms of Wolbachia intracellular accumulation in somatic cells of the Drosophila ovary. Ajit Kamath, Eva Fast, Michelle Toomey, Horacio Frydman. Biology, Boston University, Boston, MA.

618C
Molecular mechanisms for Wolbachia hub tropism in Drosophila melanogaster. Rama Krishna Simhadri, Michelle Toomey, Parthena Mantis, Ajit Kamath, Horacio Frydman. Biology, Boston University, Boston, MA.

619A
Does stem cell niche tropism favor the evolutionary success of specific Wolbachia strains? Michelle E. Toomey, Mark Deehan, Kanchana Panaram, Horacio Frydman. Biology, Boston University, Boston, MA.

Neurophysiology and Behavior

620B
Bayesian Analysis of Genetic Variation in Complex Social Group Behaviour. Brad R. Foley¹, Julia B. Saltz¹, Paul Marjoram^1,2, Sergey Nuzhdin¹. 1) Mol Comp Bio, Univ Southern California, Los Angeles, CA; 2) Preventative Medicine, Keck School of Medicine, USC, Los Angeles, CA.

621C
An Analysis of the Genetic Architecture of Aggression in Drosophila melanogaster. John R. Shorter^1,3, Charlene Couch^2,3, Robert R. H. Anholt^2,3, Trudy F. C. Mackay^1,3. 1) Genetics, North Carolina State, Raleigh, NC; 2) Biology, North Carolina State, Raleigh, NC; 3) W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC.

622A
Evaluation of the functional roles of painless and dTRPA1 in chemical nociception in Drosophila. Samantha J. Mandel, Madison L. Shoaf, Pam A. Fazio, Jason T. Braco, Wayne L. Silver, Erik C. Johnson. Wake Forest University, Winston-Salem, NC.

623B
Mutational analysis suggests that circadian period-altering mutations of DBT affect Interactions of DBT with other circadian Proteins. Anandakrishnan Venkatesan¹, Michael Muskus², Ed Bjes¹, Jeffrey Price¹. 1) University of Missouri Kansas City, Kansas City, MO; 2) Washington University, St Louis, MO.

624C
Drosophila cryptochrome achieves high effective light sensitivity by integrating photon information over extreme time periods. Pooja G. Vinayak, Jamie Coupar, S. Emile Hughes, Preeya Fozdar, Jack Kilby, Jay Hirsh. University of Virginia, Department of Biology, Charlottesville, VA.

625A
The RHO1 signaling pathway acts in circadian clock neurons to control behavioral rhythms. Herman Wijnen^1,2,3, Neethi Rao³, Rachel Siegmund³, Laura Thomason³, Ariel Talts³, Emmanuel Anyetei-Anum³. 1) Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom; 2) Institute for Life Sciences, University of Southampton, Southampton, United Kingdom; 3) Deparment of Biology, University of Virginia, Charlottesville, VA.

626B
Quantification of post-mating feeding behavior in Drosophila females. Jennifer Apger, Mariana Wolfner. Cornell University, Ithaca, NY.

627C
Male-specific isoforms of Drosophila fruitless have different transcriptional regulatory roles conferred by their distinct DNA binding domains. Michelle Arbeitman¹, Justin Dalton¹, Justin Fear², Simon Knott⁴, Bruce Baker³, Lauren McIntyre². 1) College of Medicine, Biomedical Sciences, Florida State Univ, Tallahassee, FL; 2) Genetics Institute, University of Florida, Gainesville, FL 32610-3610; 3) Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 20147; 4) Cold Spring Harbor Laboratory, One Bungtown Road Cold Spring Harbor, NY 11724.

628A
Towards a molecular and functional analysis of the Drosophila mating plug. Frank W. Avila, Fatima S. Ameerudeen, Mariana F. Wolfner. Dept Mol Biol & Gen, Cornell Univ, Ithaca, NY.

629B
jim lovell (lov) regulates behavior through roles in both the PNS and CNS. Kathleen M. Beckingham, Sonia Bjorum, Rebecca Simonette, Raul Alanis, Michael Trejo, Keith Hanson. Dept Biochem & Cell Biol, Rice Univ, Houston, TX.

630C
To Sing or to Fly: Role of Muscle Proteins in Drosophila Song and Flight Behaviors. Samya Chakravorty, Bertrand Tanner, Matthew Rosenthal, Jim Vigoreaux. University of Vermont.

631A
An RNAi screening for genes involved in female mate choice in Drosophila melanogaster. Youngmin Chu, Rui Sousa Neves. Department of Biology, Case Western Reserve University, Cleveland, OH.

632B
Investigation of how the presence of a female germline and the receipt of sperm during mating influences gene expression changes in adult female head tissues after mating. Nicole R. Newell¹, Justin E. Dalton¹, Peter L. Chang², Sergey V. Nuzhdin², Michelle N. Arbeitman¹. 1) Biomedical Science, Florida State University, Tallahassee, FL; 2) Molecular & Computational Biology, University of Southern California, Los Angeles, CA.

633C
Sexually experienced Drosophila melanogaster males are better at courting and competing for mates. Sehresh Saleem, Ginger E. Carney. Texas A&M University, College Station, TX.

634A
Characterization of novel genes affecting male courtship and mating behavior in Drosophila melanogaster. Janna Schultzhaus, Ginger Carney. Biology, Texas A&M, College Station, TX.

635B
The ontogeny of feeding behavior. Maria A. Carvalho¹, Beryl Jones², Christen K. Mirth¹. 1) Instituto Gulbenkian de Ciência, Oeiras, Portugal; 2) Janelia Farm Research Campus, Ashburn VA, USA.

636C
Increased dopamine induces lethal foraging in Drosophila. Wanhao Chi, Cristi Frazier, Liwen Xu, Jeff Beeler, Xiaoxi Zhuang. Neurobiology, University of Chicago,IL.

637A
Direct comparison of Drosophila food intake assays. Sonali A. Deshpande, Ariadna Amador, Sany Hoxha, Angela M. Phillips, William W. Ja. Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL.

638B
Regulation of Drosophila feeding, growth, and development: linking neural precursor identity to functional significance. Amy L. Gresser, Brian Gebelein. Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

639C
Decision-making neurons for feeding behavior revealed by thermogenetic activation in Drosophila. Shinya Iguchi, Michael Gorczyca, Motojiro Yoshihara. Neurobiology, UMASS Med, Worcester, MA.

640A
Dissecting the Dopaminergic Circuitry Underlying Feeding Behavior in Drosophila. Lay Kodama¹, Qili Liu¹, Mark Wu^1,2. 1) Department of Neurology, Johns Hopkins University, Baltimore, MD; 2) Department of Neuroscience, Johns Hopkins University, Baltimore, MD.

641B
Acid taste detection in Drosophila. Sandhya Charlu¹, Zev Wisotsky², Adriana Medina³, Anupama Dahanukar^1,2,3. 1) Biomedical Sciences Graduate Program, UC Riverside; 2) Interdepartmental Neuroscience Program, UC RIverside; 3) Department of Entomology, IIGB, UC Riverside.

642C
Gustatory perception regulates the behavioral response to starvation. Nancy J. Linford, Scott D. Pletcher. Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.

643A
Modularity of Function among Rickets-expressing neurons in the Wing Expansion Network of Drosophila. Feici Diao¹, Fengqiu Diao¹, Chun-yuan Ting², Chi-hong Lee², Benjamin White¹. 1) NIMH, NIH,Bethesda,MD; 2) NICHD, NIH,Bethesda,MD.

644B
The Drosophila fat body modulates sexually dimorphic responses to stress. Wendi S. Neckameyer, Kathryn J. Argue. Dept Pharmac & Physiol Sci, St Louis Univ School Med, St Louis, MO.

645C
Neurotransmitter receptors regulate ecdysteroid biosynthesis and developmental transition in Drosophila. Yuko Shimada¹, Yosuke Umei¹, Jevgenija Maramzina¹, Ryusuke Niwa^1,2. 1) Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan; 2) PRESTO, JST, Japan.

646A
Deciphering how general anesthetics work: the role of ion channels. Joel P. Goodman¹, Trevor Batty¹, Winnie Cheung¹, J. Ryan Jackson¹, Michael J. Murray², Gerald B. Call¹. 1) Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ; 2) Department of Anesthesiology, Mayo Clinic, Scottsdale, AZ.

647B
The ion channel seizure regulates Adipokinetic hormone cell excitability. Rebecca J. Perry, Jason T. Braco, Erik C. Johnson. Department of Biology, Wake Forest University, Winston-Salem, NC.

648C
Genetic variation in associative learning ability of Drosophila melanogaster larvae. Seana Lymer, Julia Saltz, Sergey Nuzhdin. University of Southern California, Los Angeles, CA.

649A
Mapping Glial Circuits Underlying Neuronal Function and Behavior in Drosophila. Taylor R. Fore¹, Camille Milton*¹, Alexander Nasr*¹, Kody McKay*², Jered Stowers¹, Hong Bao¹, Bing Zhang¹. 1) Department of Biology, University of Oklahoma, Norman, OK; 2) Department of Biological Sciences, Southwestern Oklahoma State University, Weatherford, OK.

650B
Individual leg tracking reveals the basic building blocks of behavior. James S. Kain¹, Chris Stokes¹, Quentin Gaudry², Xiangzhi Song^1,3, James Foley¹, Rachel Wilson², Benjamin de Bivort^1,4. 1) The Rowland Institute at Harvard, Cambridge, MA; 2) Department of Neurobiology, Harvard Medical School, Boston, MA; 3) College of Chemistry & Chemical Engineering, Central South University, Changsha, China; 4) Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.

651C
Sensory modalities relevant for the walking behavior of adult Drosophila melanogaster. Cesar S. Mendes¹, Imre Bartos², Turgay Akay³, Szabolcs Marka², Richard Mann¹. 1) Columbia University, Dept. Biochemistry and Molecular Biochemistry, , New York, NY; 2) Columbia University Dept. of Physics New York , NY; 3) Columbia University Dept. of Neurological Surgery, New York, NY.

652A
Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer’s disease model. Ashley A. Zervos, William Reube, Felice Elefant. Dept Biol, Drexel Univ, Philadelphia, PA.

653B
Mechanisms of force generation and auditory amplification in auditory neurons of Drosophila melanogaster. Somdatta Karak¹, Julia Jacobs², Maurice Kernan³, Daniel Eberl², Martin Goepfert¹. 1) Schwann Schleiden Forschungszentrum, Univ of Goettingen, Goettingen, Niedersachsen, Germany; 2) 269BB, Dept. of Biology, Univ of Iowa, Iowa, IA 52242, USA; 3) Dept. of Neurobiology and Behavior, SUNY, New York, USA.

654C
Dopamine and ecdysone acutely modulate AKH signaling during physiological stress in Drosophila. Jason T. Braco, Greg E. Alberto, Emily L. Gillespie, Erik C. Johnson. Biology, Wake Forest University, Winston-Salem, NC.

655A
The temporal pattern of neural activity underlying ecdysis behavior is regulated by neuropeptides downstream of Ecdysis Triggering Hormone. John Ewer, Wilson Mena. Centro Interdisciplinario de Neurociencias, Universidad de Valparaiso, Valparaiso, Valparaiso, Chile.

656B
Neuropeptide signaling is required for tissue damage-induced nociceptive sensitization in Drosophila larvae. Seol-Hee Im¹, Daniel Babcock¹, Felona Gunawan², Michael Galko¹. 1) Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX; 2) Department of Biochemistry Cell and Molecular Biology, Rice University, Houston, TX.

657C
Control of Body Size by TGF-β Signaling. Lindsay Moss-Taylor, Michael O'Connor. University of Minnesota, Minneapolis, MN.

658A
Dopamine Can Regulate Period of the Drosophila Circadian Clock. Karol Cichewicz¹, Emma Garren¹, Magali Iché-Torres², Serge Birman², Jay Hirsh¹. 1) Biology, University of Virginia, Charlottesville, VA; 2) CNRS, ESPCI, Paris.

659B
Functional DTH expression from undriven UAS-DTHg. Emma J. Garren, Karol Cichewicz, Jay Hirsh. Biology, University of Virginia, Charlottesville, VA.

660C
The Effect of Peripheral and Central Histamine Deficiency on Courtship Behavior in Drosophila melanogaster. Judith A. Ingles¹, Anthony Hage¹, Shelby Lemke^1,3, Martin G. Burg^1,2. 1) Biomedical Sciences, Grand Valley State University, Allendale, MI; 2) Cell & Molecular Biology, Grand Valley State University, Allendale, MI; 3) Univ. of Michigan Med. School, Univ. of Michigan, Ann Arbor, MI.

661A
Virtual Fly Brain. Cahir J. O'Kane¹, David Osumi-Sutherland¹, Marta Costa¹, Nestor Milyaev², Gregory Jefferis³, J. Douglas Armstrong². 1) Department of Genetics, University of Cambridge, Cambridge, UK; 2) Institute for Adaptive and Neural Computation, University of Edinburgh, Edinburgh, UK; 3) MRC Laboratory of Molecular Biology, Cambridge, UK.

662B
Neurochemical Analysis of Drosophila Syndecan Mutants. LaPortia Pierce¹, Marleshia Hall², Olugbenga Doherty², Maria Deluca³, Janis O'Donnell². 1) Department of Natural Sciences, Stillman College, Tuscaloosa, AL; 2) Department of Biological Sciences, University of Alabama, Tuscaloosa, AL; 3) Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL.

663C
Two odor receptors contribute distinct and complex signals in response to structurally similar odor molecules. Scott A. Kreher, Christine Nguyen, Abhiram Nagaraj, Jorge Gacharna, Lorien Menhennett, Raquel Robles, Michael Wesolowski. Department of Biological Sciences, Dominican University, River Forest, IL.

664A
A phospholipid flippase essential for olfactory neuron function in Drosophila . Coral G. Warr, Yu-Chi Liu, Takahiro Honda, Michelle Pearce, Marien de Bruyne. School of Biological Sciences, Monash University, Clayton, VIC, Australia.

665B
Evaluating potential mechanisms underlying hormetic responses. Elizabeth J. Ales, Erik C. Johnson. Biology, Wake Forest University, Winston-Salem, NC.

666C
JAABA: An interactive machine-learning tool for automatic annotation of animal behavior. Kristin Branson¹, Mayank Kabra¹, Alice A. Robie¹, Marta Rivera-Alba^1,2, Steven Branson^1,3. 1) HHMI Janelia Farm Research Campus, Ashburn, VA; 2) Instituto Gulbenkian de Ciência, Oeiras, Portugal; 3) Dept. of Computer Science and Engineering, UC San Diego, La Jolla, CA.

667A
Dissecting the Mechanism of Parkinson’s Disease Using Drosophila model. Dongsheng Chen. Metablic and Degenerative Disease Center, Institute of Molecular Medicine, Houston, TX.

668B
Dopamine neurons drive competing actions for alcohol preference in Drosophila. Karla R. Kaun, Reza Azanchi, Yoshinori Aso, Gerald M. Rubin, Ulrike Heberlein. Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147.

669C
Neural dissection of active predator avoidance behavior in Drosophila. Claire J. Manson-Bishop, Gregg W. Roman. Biology and Biochemistry, University of Houston, Houston, TX.

670A
Behavioral contributions of the 12 neuron types in the fly lamina. Michael B. Reiser¹, John C. Tuthill^1,2, Aljoscha Nern¹, Gerry Rubin¹. 1) Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA; 2) Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA.

671B
Elucidation of Drosophila melanogaster G protein coupled receptor interactions through heterodimerization and chimeric receptor studies. Michael J. Rizzo, Erik C. Johnson. Wake Forest University, Department of Biology, Winston Salem, NC 27109.

672C
Establishing Drosophila Behavioral Paradigms Analogous to Mammalian Anxiety and Depression Models. Lauren Stein, Kelly Hainz, Wendi Neckameyer. Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO.

673A
Sexual Dimorphism in Drosophila exercise motivation. Alyson Sujkowski, Sara Ginzberg, Robert Wessells. Univ Michigan, Ann Arbor, MI.

674B
Investigating the cellular bases of cold nociception in Drosophila larvae. Luis Sullivan, Srividya C. Iyer, Eswar P. R. Iyer, Kevin Armengol, Daniel N. Cox. School of Systems Biol., Krasnow Inst. Adv. Study, George Mason University, Fairfax, VA.

675C
A novel mutation in the Drosophila slingshot (ssh) gene identifies a requirement for its function in the maintenance of synapse morphology. Jason E. Duncan, Kayla Johnson. Department of Biology, Willamette University, Salem, OR.

676A
Synaptic homeostasis is regulated by the kinesin motor protein Khc-73 in Drosophila melanogaster. Edward H. Liao, Kazuya Tsurudome, Wassim El Mounzer, Frances Wang, Fatima Elazzouzi, Pejmun Haghighi. Dept Physiology, McGill University, Montreal, QC, Canada.

677B/ Unprogrammed presentation number

Cell Biology and Cytoskeleton

679B
Talin autoinhibition is required for morphogenesis. Stephanie J. Ellis¹, Jenny Long², Michael J. Fairchild¹, Paolo Lobo³, Stefan Czerniecki¹, Filip van Petegem³, Frieder Schöck², Guy Tanentzapf¹. 1) Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada; 2) Biology Department, McGill University, Montreal, PQ, Canada; 3) Department of Biochemistry, University of British Columbia, Vancouver, BC, Canada.

680C
Septins regulate contractility of the actomyosin ring to enable adherens junction remodeling during cytokinesis of epithelial cells. Roland Le Borgne, Nabila Founounou, Nicolas Loyer. Institute of Genetics and Development of Rennes CNRS UMR 6290-Faculté de Médecine 2 av du Pr. Bernard 35000 Rennes FRANCE.

681A
Region-specific activity of the Diego protein in Planar Cell Polarity. Simon Collier¹, Hugh Cahill². 1) Dept Biological Sci, Marshall Univ, Huntington, WV; 2) School of Medicine, Marshall Univ, Huntington, WV.

682B
Fat2 controls planar microtubule alignment in the Drosophila follicle epithelium. Christian Dahmann, Ivana Viktorinova. Institute of Genetics, Dresden University of Technology, Dresden, Germany.

683C
Analysis of Integrator 1 function in Drosophila epithelial cells. Timm Haack, Dan T. Bergstralh, Daniel St. Johnston. The Gurdon Institute and the Department of Genetics, University of Cambridge, Cambridge, United Kingdom.

684A
The role of Dachsous and Fat in regulating planar cell polarity across the embryonic epidermis. Kynan Lawlor, Stephen DiNardo. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

685B
Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization. Soojin Lee, Seung Yeop Han, Minjung Lee, Kyoung Sang Cho. Department of Biological sciences, Kunkok university, Seoul, Seoul, South Korea.

686C
Moesin negatively regulates Crumbs at the marginal zone in Drosophila follicle cells. Kristin Sherrard, Richard Fehon. Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.

687A
Regulation of cell polarity and morphogenesis by Tousled-like kinase in Drosophila. Jenn-Yah Yu, Tsung-Han Yeh, Shu-Yu Huang, Gwo-Jen Liaw. Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan.

688B
Proper ER Morphology in the Drosophila Syncytial Embryo Depends on Reticulon-like Proteins. Zane J. Bergman, Justin D. Mclaurin, Amanda Q. Sims, Blake Riggs. Biology, San Francisco State University, San Francisco, CA.

689C
A Deficiency Screen to Identify Regions of the Third Chromosome that Genetically Interact with Activated Abl. Lacey Berry, Traci L. Stevens. Biology, Randolph-Macon College, Ashland, VA.

690A
Determining the roles of Dock proteins in dorsal vessel development. Bridget H. Biersmith, Erika R. Geisbrecht. Division of Cell Biology & Biophysics, University of Missouri-Kansas City, Kansas City, MO.

691B
Cellular blebbing in the ventral furrow. Jonathan S. Coravos, Adam Martin. Massachusetts Institute of Technology, Cambridge, MA.

692C
Spatial control of F-actin dynamics during pupal eye morphogenesis. Steven J. DelSignore, Victor Hatini. Cell, Molecular & Developmental Biol, Tufts Univ Sackler Sch Biomed Sci, Boston, MA.

693A
Role of formins during Drosophila embryonic myogenesis. Su Deng¹, Ingo Bothe², Mary Baylies². 1) Weill Cornell Medical College, New York, NY; 2) Memorial Sloan-Kettering Cancer Center.

694B
Group I PAKs Functions Downstream of Rac to Regulate Podosome Invasion During Myoblast Fusion in vivo. Rui Duan, Peng Jin, Fengbao Luo, Elizabeth Chen. Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD.

695C
Centrosomal and acentrosomal microtubules collaborate to direct the dorsal localisation of gurken mRNA in Drosophila oocyte. Rippei Hayashi, Mark Wainwright, Sophie Liddell, Sheena Pinchin, David Ish-Horowicz. Developmental Genetics Laboratory, London Research Institute, Cancer Research UK, London, London, United Kingdom.

696A
The love-hate relationship between APC2 and Diaphanous: Dissecting the mechanism of APC2-Diaphanous dependent actin assembly in the Drosophila syncytial embryo. Ezgi Kunttas-Tatli¹, Rebecca Webb², Orr Rozov¹, Kelly Shibuya¹, Brooke M. McCartney¹. 1) Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA; 2) Biology Department, University of Pittsburgh at Johnstown, Johnstown, PA.

697B
Exploring mechanisms of Troponin-T isoform switching and regulation of stoichiometry in the Troponin complex of Drosophila Indirect Flight Muscles. Aditi Madan, Divesh Thimmaiya, Prabodh Kumar, Upendra Nongthomba. MRDG, Indian Institute of Science, Bangalore, India.

698C
Polarized contraction coupled to F-actin turnover is required for pulsed contractions. Adam C. Martin, Frank M. Mason, Mike Tworoger. Biology, Massachusetts Institute of Technology, Cambridge, MA.

699A
Drosophila septins bundle and curve actin filaments. Manos Mavrakis¹, Yannick Azou¹, Feng-Ching Tsai², José Alvarado², Aurélie Bertin³, Francois Iv¹, Gijsje Koenderink², Thomas Lecuit¹. 1) Institut de Biologie du Développement de Marseille Luminy, CNRS UMR7288, Aix-Marseille University, Marseille, France; 2) FOM Institute AMOLF, Amsterdam, The Netherlands; 3) Institut de Biochimie et de Biophysique Moléculaire et Cellulaire, CNRS UMR8619, Université Paris-Sud, Orsay, France.

700B
The role of Dynein Heavy Chain in Drosophila bristle growth. Anna Melkov, Uri Abdu. Department of Life Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.

701C
Mechanisms of APC-Diaphanous mediated actin assembly. Olivia Molinar¹, Richa Jaiswal², Aneliya Rankova², Vince Stepanik¹, Bruce L. Goode², Brooke M. McCartney¹. 1) Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA; 2) Department of Biology, Brandeis University, Waltham, MA.

702A
A Genetic Screen Identifies Myo-V as a Component of Abl Signaling Pathways. Sierra K. Mosticone-Wangensteen, Traci L. Stevens. Biology, Randolph-Macon College, Ashland, VA.

703B
A novel role for the non-catalytic intracellular domain of Neprilysins in muscle physiology. Mareike Panz¹, Arne Jendretzki², Jürgen Heinisch², Achim Paululat¹, Heiko Harten¹. 1) Zoology, University of Osnabruck, Osnabruck, Germany; 2) Genetics, University of Osnabruck, Osnabruck, Germany.

704C
Rho1 functions through multiple effectors for proper epithelial wound repair. Travis K. Rahe, Jeffrey M. Verboon, Susan M. Parkhurst. Division of Basic Sciences, Fred Hutchinson Cancer Research Institute, Seattle, WA.

705A
The role of the motor protein, kinesin heavy chain, in Drosophila bristle development. Yasmin Simkhoni, Uri Abdu. Department of Life Sciences, Ben-Gurion University, Beer-Sheva, Israel.

706B
Morphogenetic apoptosis : a force generation mechanism. Magali Suzanne, Melanie Gettings, Bruno Monier, Thomas Mangeat. Paul Sabatier University, LBCMCP, Toulouse, France.

707C
Identification of cytoskeletal genes that are essential for lifelong maintenance of muscle function. Guy Tanentzapf, Alexander D. Perkins, Michael Lee, Fayeza Islam. CPS Dept, Univ British Columbia, Vancouver, BC, Canada.

708A
Calling the Shots: Prostaglandins Temporally Regulate Actin Remodeling During Drosophila Oogenesis. Tina L. Tootle, Andrew J. Spracklen, Xiang Chen. Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA.

709B
Characterization of the Bristle mutant in Drosophila melanogaster. Pooneh Vaziri, Eduardo Gonzalez-Niño, Jennifer Curtiss. New Mexico State University , Las Cruces, NM.

710C
The Identification and Characterization of a New Protein Essential for Drosophila Myotendinous Junction Formation. Zongheng Wang. University of Missouri-Kansas City, Kansas City, MO.

711A
A Screen to Identify Genes that Interact with Abl Tyrosine Kinase in Drosophila. Selena Washington, Traci L. Stevens. Biology, Randolph-Macon College, Ashland, VA.

712B
Twinstar is required for muscle development. Shannon F. Yu^1,2, Mary K. Baylies². 1) Gerstner Sloan-Kettering Graduate School, New York, NY; 2) Sloan-Kettering Institute, New York, NY.

713C
UBPY Controls the Stability of ESCRT-0 Complex in Development. Junzheng Zhang, Ying Su, Min Liu, Alan Jian Zhu. Dept. of Cellular & Molecular Medicine, Lerner Res Inst, Cleveland Clinic, Cleveland, OH.

714A
Cardiac integrity and function depends on the ADAMTSL protein Lonely heart. Maik Drechsler, Ariane Schmidt, Heiko Meyer, Achim Paululat. Department of Zoology/Developmental Biology, University of Osnabrueck, Osnabrueck, Germany.

715B
Molecular mechanisms underlying the intracellular distribution of ZP proteins for epidermal differentiation. Francois Payre^1,2, Helene Chanut-Delalande^1,2, Delphine Menoret^1,2, Serge Plaza^1,2. 1) Centre for Developmental Biology, University of Toulouse, Toulouse, France; 2) CNRS, UMR5547, Toulouse, France.

716C
Disruption of Rab protein vesicle transport by loss of huntingtin in vivo. Shermali D. Gunawardena, Derek Power, Shruthi Srinivasan. Biological Sciences, SUNY at Buffalo, Buffalo, NY.

717A
The Role of tbc-1 in Drosophila Salivary Gland Development. Dorothy M. Johnson, Deborah Andrew. Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.

718B
Atlastin regulates lipid-droplet in Drosophila melanogaster fat bodies. Han Lee¹, Diana Jin², Yi Guo². 1) Dept of Neurobiology of Disease, Mayo Graduate School, Rochester, MN; 2) Dept of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN.

719C
AP-1-dependent E-Cadherin trafficking in Drosophila oogenesis. Nicolas Loyer, Roland Le Borgne. CNRS UMR 6290-IGDR, Rennes, France.

720A
Roles of phosphatidylinositol 4-phosphate in Drosophila larval secretory granule biogenesis. Cheng-I J. Ma^1,2, Jason Burgess^2,3, Lauren M. Del Bel^2,3, Barbara Barylko⁴, Gordon Polevoy², Janet Rollins⁵, Joseph P. Albanesi⁴, Helmut Krämer⁶, Julie A. Brill^1,2,3. 1) Institute of Medical Science, University of Toronto, Toronto, ON, Canada; 2) Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; 3) Department of Molecular Genetics, University of Toronto, ON, Canada; 4) Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA; 5) Division of Natural Sciences, The College of Mount Saint Vincent, Riverdale, NY, USA; 6) Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.

721B
Rab8 is Required for the Regulation of Invagination of the Furrow Canal in Cellularization During Drosophila Embryogenesis. Lauren Mavor, J. Todd Blankenship. Biological Sciences, University of Denver, Denver, CO.

722C
Ykt6, a conserved v-SNARE, is required in neuronal function and maintenance. Kai Li Tan¹, Shinya Yamamoto², Manish Jaiswal², Hector Sandoval², Gabriela David¹, Bo Xiong¹, Wu-Lin Charng¹, Ke Zhang⁴, Vafa Bayat³, Hugo J. Bellen^1,2,4,5,6. 1) Program in Developmental Biology; 2) Department of Molecular and Human Genetics; 3) MSTP; 4) SCBMB Program; 5) HHMI; 6) Department of Neuroscience; Neurological Research Institute at Baylor of College of Medicine, Houston, TX.

723A
The retromer complex is required for photoreceptor maintenance and Rhodopsin recycling. Shiuan Wang¹, Bo Xiong¹, Shinya Yamamoto², Kai Li Tan¹, Hector Sandoval², Manish Jaiswal², Vafa Bayat³, Ke Zhang⁴, Wu Lin Charng¹, Gabriela David¹, Hugo Bellen^1,2,4,5,6. 1) Program in Developmental Biology; 2) Department of Molecular and Human Genetics; 3) MSTP; 4) SCBMB Program; 5) HHMI; 6) Department of Neuroscience; Neurological Research Institute at Baylor of College of Medicine, Houston, TX.

724B
Klar modulates oskar RNP transport in the Drosophila oocyte. Michael A. Welte¹, Imre Gáspár², Yanxun V. Yu^1,3, Anne Ephrussi². 1) Dept Biol, University of Rochester, Rochester, NY; 2) Developmental Biology Unit, EMBL, Heidelberg, Germany; 3) Dept Biology, Brandeis University, Waltham, MA.

725C
Crag is a GEF for Rab11 and regulates Rhodopsin trafficking in adult photoreceptor cells. Bo Xiong¹, Manish Jaiswal², Ke Zhang³, Hector Sandoval⁴, Wu-Lin Charng¹, Tongchao Li¹, Gabriela David¹, Shinya Yamamoto^1,4, Hugo Bellen^1,2,3,4,5,6. 1) PROGRAM IN DVELOPMENTAL BIOLOGY, BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX; 2) Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX; 3) Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX; 4) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 5) Department of Neuroscience, Baylor College of Medicine, Houston, TX; 6) Neurological Research Institute, Baylor College of Medicine, Houston, TX.

726A
Basal cell protrusive activity is a primary determinant of follicle cell planar polarity. Maureen P. Cetera¹, Lindsay Lewellyn¹, Michael J. Fairchild², Guy Tanentzapf², Sally Horne-Badovinac¹. 1) Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL; 2) Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC.

727B
Differential phosphorylation of the myosin light chain by multiple kinase pathways is required for collective cell migration. Jocelyn A. McDonald^1,2, Pralay Majumder¹, George Aranjuez^1,2, Ashley Burtscher¹. 1) Molecular Genetics, Cleveland Clinic, Cleveland, OH; 2) Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH.

728C
Emergence of embryonic pattern through contact inhibition of locomotion. Brian M. Stramer, John Davis, Chieh-Yin Huang, Jennifer Zanet, Daniel Soong, Graham Dunn. Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom.

729A
The influence of the myosin converter domain on muscle function in Drosophila. Bernadette Glasheen, Seemanti Ramanath, Qian Wang, Debra Sheppard, Lauren Riley, Douglas Swank. Center for Biotechnology and Interdisciplinary Studies, Department of Biology, Rensselaer Polytechnic Institute, Troy, NY.

730B
Characterization of septate junction biogenesis during embryogenesis in Drosophila. Sonia Hall, Jennifer Mendez, Sam Long, Robert Ward. Molecular Biosciences, University of Kansas, Lawrence, KS.

731C
Formation and remodeling of the muscle cell T-tubule membrane network. Amy Kiger, Jen Nguyen, Ines Ribeiro, Naonobu Fujita. Cell & Dev Biol, Univ California, San Diego, La Jolla, CA.

732A
Rab-mediated secretion of lipoproteins in Drosophila melanogaster. Sebastian Dunst, Marko Brankatschk, Anja Zeigerer, Marino Zerial, Suzanne Eaton. MPI-CBG, Dresden, Germany.

733B
Apical targeting of Diaphanous mediates polarized secretion in tubular organs. Eyal D. Schejter, Tal Rousso, Rada Massarwa, Erez Geron, Ben-Zion Shilo. Dept Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Pattern Formation

734C
Novel interactions between the NF-κB and BMP signaling pathways in the Drosophila melanogaster embryo. Sophia Carrell, Gregory Reeves. Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC.

735A
Lack of Functional Conservation in Early Axial Patterning of the Drosophila Embryo. Jackie F. Gavin-Smyth¹, Daniel R. Matute², Martin Krietman¹, John Reinitz¹. 1) Ecology and Evolution, University of Chicago, Chicago, IL; 2) Dept. of Human Genetics, University of Chicago, Chicago, IL.

736B
Essential roles for stat92E in patterning the proximodistal axis of the Drosophila wing imaginal disc. Victor Hatini, Ela Kula, David Nusinow, Steven DelSignore. Dept Anatomy & Cellular Biol, Tufts Univ, Boston, MA.

737C
Reduced cell number in the hindgut epithelium disrupts hindgut left-right asymmetry in a mutant of pebble, encoding a RhoGEF, in Drosophila embryos. Mitsutoshi Nakamura^1,2, Kenjiroo Matsumoto^1,2, Yuta Iwamoto^1,2, Ryo Hatori^1,2, Kenji Matsuno¹. 1) Dept, Biol Sci, Osaka univ, Toyonaka, Japan; 2) Dept, Bio/Tech, Tokyo Univ of Sci, Noda, Japan.

738A
Dorso-ventral patterning of the embryonic epidermis. Francois Payre^1,2, Ahmad Alsawadi^1,2, Robin Vuilleumier³, Philippe Valenti^1,2, Jennifer Zanet^1,2, Giorgos Pyrowolakis³, Serge Plaza^1,2. 1) Developmental Biology, University of Toulouse, Toulouse, France; 2) CNRS, UMR5547, Toulouse, France; 3) Institute for Biology I, University of Freiburg, Freiburg, Germany.

739B
The maternal-effect phenotype of the delorean mutation in Drosophila melanogaster. Georgette Sass, Sarah VanOeveren. Biology, Grand Valley State University, Allendale, MI.

740C
Taranis regulates posterior identity during imaginal disc regeneration. Keaton J. Schuster, Andrea Skinner, Rachel K. Smith-Bolton. Cell & Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL.

741A
Drosophila microRNA-9a modulates the process of muscle attachment assembly via downregulation of Dystroglycan. Andriy S. Yatsenko, Halyna R. Shcherbata. MPRG Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany.

742B
Homeodomain interacting protein kinase promotes normal and ectopic eye development through the repression of pax6 paralogs twin of eyeless and eyeless. Jessica A. Blaquiere¹, Wendy Lee^1,2, Esther M. Verheyen¹. 1) Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; 2) Dermatology and Cell Biology, NYU Langone Medical Center and School of Medicine, New York University, New York, NY, USA.

743C
Blimp-1 Participates in Patterning during Pupal Eye Development. Carrie L. Jenkins¹, Gerald B. Call². 1) Biomedical Sciences, Midwestern University, Glendale, AZ; 2) Dept. of Pharmacology, Midwestern University, Glendale, AZ.

744A
Midline Functions within the Notch-Delta Signaling Pathway Regulating Interommatidial Bristle Complex Formation within the Developing Eye of Drosophila . Sandra M. Leal, Sudeshna Das. Dept Biological Sci, Univ Southern Mississippi, Hattiesburg, MS.

745B
defective proventriculus (dve), a new member of DV patterning in the eye. Oorvashi Roy G. Puli¹, Takeshi Yorimitsu³, Hideki Nakagoshi³, Amit Singh^1,2,4. 1) Department of Biology, University of Dayton, 300 College Park Drive, Dayton, OH; 2) Premedical Program, University of Dayton, 300 College Park Drive, Dayton, OH; 3) School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan; 4) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH.

746C
Segregation of Eye and Antenna Fates: Initiation and Maintenance. Y. Henry Sun^1,2, Cheng-Wei Wang^1,2, Hui-Yu Ku^1,2. 1) Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China; 2) Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China.

747A
Domain specific function of Cullin-4 to promote cell survival in the ventral eye compartment in Drosophila . Meghana Tare¹, Madhuri Kango-Singh^1,2,3, Amit Singh^1,2,3. 1) Department of Biology, University of Dayton, 300 College Park Drive,Dayton, OH 45469; 2) Premedical Program, University of Dayton, 300 College Park Drive, Dayton OH 45469; 3) Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, 300 College Park Drive, Dayton OH 45469.

748B
Abams is a member of the neprilysin family of metallopeptidases that affects signaling pathways during Drosophila melanogaster eye development. Christine Woods, Landry Nfonsom, Jennifer Curtiss. New Mexico State University, Las Cruces, NM.

749C
Retrograde trafficking of apical extracellular matrix protein regulates epithelial tube geometry. Bo Dong¹, Ken Kakihara^1,2, Tetsuhisa Otani¹, Housei Wada¹, Shigeo Hayashi^1,2. 1) Riken CDB, Kobe, Japan; 2) Department of Biology, Kobe University Graduate School of Science.

750A
Screening for regulatory sequences that pattern the Drosophila eggshell. Nicole Pope, Maira Farhat, Robert A. Marmion, Nir Yakoby. Biology, Rutgers University- Camden, Camden, NJ.

751B
Function of PCP effector proteins, In, Fy and Frtz, in regulating planar cell polarity. Ying Wang¹, Jie Yan¹, Paul Adler^1,2. 1) Biology, University of Virginia, CHARLOTTESVILLE, VA; 2) Cell Biology,University of Virginia, CHARLOTTESVILLE, VA.

752C
Systematic Identification of Ftz and Ftz-F1 Responsive Target Genes and Their Enhancers. Amanda Field¹, Ray Anderson¹, Jie Xang¹, Leslie Pick^1,2. 1) Program in Molecular & Cell Biology, University of Maryland, College Park, MD; 2) Department of Entomology, University of Maryland, College Park, MD.

753A
Gap-gap cross-regulation in mid-embryo pattern formation: deterministic and stochastic modelling of hunchback-Krüppel interactions. David M. Holloway¹, Alexander V. Spirov^2,3. 1) Dept Mathematics, British Col Inst Tech, Burnaby, BC, Canada; 2) Computer Science and CEWIT, Stony Brook University, NY, USA; 3) Sechenov Institute for Evolutionary Physiology and Biochemistry, St. Petersburg, Russia.

754B
Describing the balance between cooperative binding and self-activation during pattern formation in Drosophila melanogaster. Francisco J. P. Lopes^1,2, Alexander V. Spirov^3,4, Paulo M. Bisch¹. 1) Instituto de Biofisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 2) Polo de Xerem, Universidade Federal do Rio de Janeiro, Duque de Caxias, Brazil; 3) Laboratory of Evolutionary Modelling, the Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint-Petersburg, Russia; 4) Computer Science Department and Center of Excellence in Wireless & Information Technology, State University of New York at Stony Brook, Stony Brook, USA.

755C
Signals from the pouch and notum restrict JAK/STAT signaling to the hinge to insure proper wing development. Erika Bach, Aidee Ayala-Camargo, Aloma Rodrigues, Marc Amoyel, Maria Sol Flaherty. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY.

756A
BMP signaling requires an inwardly rectifying K+ channel to pattern Drosophila wing. Giri Raj Dahal, Brandon Gassaway, Ben Kwok, Emily Bates. Chemistry and Biochemistry, Birgham Young University, Provo, UT.

757B
Inverse Regulation of Target Genes at the Brink of the Dpp Morphogen Activity Gradient. Offer Gerlitz¹, Oren Ziv¹, Rutie Finkelstein¹, Yaron Suissa¹, Tama Dinur¹, Girish Deshpande². 1) Developmental Biology and Cancer Research, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; 2) Department of Molecular Biology, Princeton University, Princeton, NJ 08540.

758C
The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis. Fabrice Roegiers, Diana Zitserman. Inst Cancer Res, Fox Chase Cancer Ctr, Philadelphia, PA.

Physiology and Aging

759A
The role of dietary restriction in age-related muscle atrophy. Guiping Du, Jennika Krisa, Patrick Li, Subhash Katewa, Aric Rogers, Matthew Laye, Pankaj Kapahi. Buck Institute for Research on Aging, Novato, CA.

760B
A metabolomics approach identifies β-Sitosterol to increases Longevity in adult Drosophila melanogaster. Matthew J. Laye, Kisha Barrett, Pankaj Kapahi. Buck Institute, Novato, CA.

761C
Is oxygen limitation a cue for the initiation of molting in Drosophila? Viviane Callier¹, Colin Brent², Jinkyu Kim¹, Shampa M. Ghosh³, Alexander W. Shingleton³, Jon F. Harrison¹. 1) School of Life Sciences, Arizona State University, Tempe, AZ; 2) USDA-ARS Arid-Land Agricultural Research Center, Maricopa, AZ; 3) Department of Zoology, Michigan State University, East Lansing, MI.

762A
Trans-interactions at Men in Drosophila melanogaster demonstrate environmental plasticity. Xinyang Bing¹, Teresa Rzezniczak², Thomas Merritt¹. 1) Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada; 2) Institute of Biochemistry, Carleton University, Ottawa, ON, K1S 5B6, Canada.

763B
The effect of altered mitochondrial function on larval development and adult lifespan. Rachel T. Cox, Aditya Sen. Dept Biochemistry and Molecular Bio, Uniformed Services University, Bethesda, MD.

764C
Drosophila melanogaster harbor the machinery to mediate an insulin-responsive sugar uptake response. Georgeta Crivat¹, Vladimir Lizunov², Caroline Li¹, Karin Stenkula³, Joshua Ziammerberg², Samuel Cushman², Leslie Pick¹. 1) Entomology, University of Maryland, College Park, MD; 2) Laboratory of Cellular and Molecular Biophysics, Program on Physical Biology, Eunice Kennedy Schriver National Institute of Child Health and Human Development, and the Experimental Diabetes, Metabolism, and Nutrition Section, Diabetes, Endocrinology, and; 3) Department of Experimental Medical Science, Lund University BMC F10, SE-221 84 Lund, Sweden.

765A
The TGF-β/Activin ligand daw regulates sugar and pH homeostasis in Drosophila melanogaster. Arpan Ghosh, Michael O'Connor. Gen Cell & Development, Univ Minnesota Twin Cities, Minneapolis, MN.

766B
The Control of Lipid Metabolism by mRNA Splicing in Drosophila. Robert Gingras¹, Bijal Kakrecha³, Nicole Chichearo³, Spencer Ng², Justin DiAngelo¹, Alexis Nagengast². 1) Dept Biol, Hofstra U, NY; 2) Dept Biochem, Widener U, PA; 3) Dept Biol, Widener U, PA.

767C
Lost in Translation: mitochondrial and nuclear incompatibility results in reduced longevity and increased oxidative stress resistance in Drosophila. Marissa A. Holmbeck, David M. Rand. Bio-Med, Brown University, Providence, RI.

768A
Regulation of fatty acid metabolism by the nuclear receptor DHR78. Stefanie M. Marxreiter, Carl S. Thummel. Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT.

769B
A recessive X-linked mutation causing a 3-fold reduction in total body zinc content is widespread within Drosophila melanogaster laboratory strains. Fanis Missirlis¹, Negar Afshar², Bilge Argunhan², Lucia Bettedi², Joanna Szular². 1) Departamento de Fisiología, Biofísica y Neurociencias, CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS (CINVESTAV), Mexico City, D.F., Mexico; 2) School of Biological and Chemical Sciences Queen Mary, University of London Mile End Road, London, United Kingdom E1 4NS.

770C
Transgenerational Inheritance of Metabolic State in Drosophila. Rebecca A. Somer, Carl S. Thummel. Human Genetics, University of Utah School of Medicine, Salt Lake City, UT.

771A
The role of FoxO in integrating insulin and ecdysone signaling during body size regulation. Takashi Koyama, Christen Mirth. Instituto Gulbenkian de Ciência, Oeiras, Portugal.

772B
Mio acts in the brain to control feeding and metabolism in Drosophila. Joseph Manno, Jacqueline McDermott, Justin DiAngelo. Department of Biology, Hofstra Univ, Hempstead, NY.

773C
Gustatory-mediated Neuronal Circuits Regulate Drosophila Physiology and Longevity. Michael J. Waterson¹, Tammy P. Chan², Zachary M. Harvanek³, Ivan Ostojic⁴, Joy Alcedo^4,5, Scott D. Pletcher^1,3. 1) Cellular and Molecular Biology Graduate Program, University of Michigan; 2) Department of Developmental Biology, Baylor College of Medicine, Houston, TX; 3) Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI; 4) Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; 5) Department of Biological Sciences, Wayne State University, Detroit, MI.

774A
Dietary Composition Regulates Drosophila Mobility and Cardiac Physiology. Sara Ginzberg, Brian Bazzell, Lindsey Healy, Robert Wessells. The University of Michigan, Ann Arbor, MI.

775B
Food pH and microbial growth modulate Drosophila longevity. Sany Hoxha, Ryuichi Yamada, Christine Mak, Brooke Hunter, William Ja. Department of Metabolism & Aging, The Scripps Research Institute, Jupiter, FL.

776C
The Insulin and Tor signaling pathways directly regulate cuticle melanization in Drosophila. Jennifer A. Kennell, Iryna Shakhmantsir. Biology, Vassar College, Poughkeepsie, NY.

777A
Towards complete ecdysteroidome of Drosophila melanogaster. Oksana Lavrynenko, Suzanne Eaton, Andrej Shevchenko. MPI CBG, Dresden, Germany.

778B
Brain Vacuolization and Muscle Protein Aggregation as Potential Biomarkers of Aging in Drosophila. Atanu Duttaroy¹, Kristopher Bcekwith², Peter Kibanyi Kibanyi¹, Eva Polston Polston². 1) Dept Biol, Howard Univ, Washington, DC; 2) Department of Physiology and Biophysics, Howard University, Washington, DC.

779C
Loss of the mitochondrial matrix protein Shaken not Stirring causes bang-sensitivity and early adult lethality. Daniel K. Bricker^1,3, Jon Van Vranken^2,3, Kelly J. Beumer^2,3, Dana Carroll^2,3, Jared Rutter^2,3, Carl S. Thummel^1,3. 1) Department of Human Genetics; 2) Department of Biochemistry; 3) University of Utah School of Medicine, Salt Lake City, UT.

780A
Morphological and molecular characterization of adult midgut compartmentalization in Drosophila . Nicolas Buchon^1,2, Dani Osman², Fabrice David², Jean-Philippe Boquete², Bart Deplancke², Bruno Lemaitre². 1) Cornell University, Ithaca, NY; 2) EPFL, Lausanne, Switzerland.

781B
SERF1 contribution to protein homeostasis in Drosophila melanogaster. Swagata Ghosh, Adna Karic, Susan Harrison, Douglas Harrison, Brian Rymond. Biology, University of Kentucky, Lexington, KY.

782C
Effects of rearing oxygen level on the structure of the adult tracheal system in Drosophila melanogaster. Jon F. Harrison, James Waters, Stephanie Heinrich, Taylor Biddulph, Sandra Kovacevic. School of Life Sciences, Arizona State University, Tempe, AZ.

783A
The role of the adiponectin receptor homolog in Drosophila melanogaster oogenesis. Kaitlin Laws, Leesa Sampson, Daniela Drummond-Barbosa. Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

784B
The regulation of muscle function by Mio in Drosophila. Grzegorz Polak, Justin DiAngelo. Department of Biology, Hofstra Univ, Hempstead, NY.

785C
Expression of drop-dead (drd) in the tracheae is sufficient to prevent neurodegeneration, but not early lethality. Christine L. Sansone, Edward M. Blumenthal. Biological Sci, Marquette Univ, Milwaukee, WI.

786A
Aging affects circadian control of glutathione biosynthesis in Drosophila melanogaster. Eileen Chow¹, Vladimir Klichko², Joanna Kotwica-Rolinska^1,3, Dani Long¹, William Orr², Svetlana Radyuk², Jadwiga Giebultowicz¹. 1) Department of Zoology, Oregon State University, Corvallis, OR, USA; 2) Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA; 3) Department of Animal Physiology, University of Warsaw, Warsaw, Poland.

787B
Effects of radiofrequency identifiers in embryos and pupae of Drosophila melanogaster. David A. Lavan^1,2,5, Luis Moreno², Rubén E. Acosta¹, Miguel Diaz⁵, Marcos Moroto³, Ricardo Yauri¹, Roxana Moran¹, Olga Bracamonte², Julio Valdivia-Silva⁴, Daniel Diaz¹. 1) National Institute Research of Telecommunications Training - INICTEL-UNI, Av. San Luis 1771, Lima 41, Peru; 2) Cytogenetics Laboratory, Universidad Nacional Mayor de San Marcos, Av. University s/n, Lima 1, Peru; 3) Department of Pharmacology and Therapeutics, School of Medicine, Universidad Autonoma de Madrid. Av. Morcillo 4 Madrid 28029, Spain; 4) Biotechnology and Space Medicine - NASA Ames Research Center, Build. N245 M/S:245-3, Moffett Field, CA 94035, USA; 5) Central Therapy Magnetic Field, International Institute of the Cancer and Pain; Av. Montero Rosas nº 1141 Lima 1, Peru.

788C
A genetic approach reveals selective elimination of damaged mitochondria in healthy cells and tissue. Yun Qi¹, Jahda Hill¹, Guofeng Zhang², Hong Xu¹. 1) GDBC, NHLBI, bethesda, MD; 2) NIBIB, bethesda, MD.

Regulation of Gene Expression

789A
A Novel Role for the Ribosomal Protein RpL22 in Poly(ADP-ribose)polymerase 1-Dependent Transcriptional Regulation. Ernest Boamah, Alexei Tulin. Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, Philadelphia, PA.

790B
A transcriptional code for muscle fiber identity in Drosophila. Anton L. Bryantsev¹, Sandy Duong¹, Tonya M. Brunetti¹, Maria B. Chechenova¹, TyAnna L. Lovato¹, Cloyce Nelson¹, Elizabeth Shaw¹, Juli D. Uhl², Brian Gebelein², Richard M. Cripps¹. 1) Department of Biology, University of New Mexico, Albuquerque, NM; 2) Division of Dev. Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

791C
Multiple screening approaches identify novel transcription factor binding partners for Eyes absent. Trevor L. Davis^1,2, Ilaria Rebay^1,2. 1) Committee on Development, Regeneration, and Stem Cell Biology, University of Chicago, Chicago, IL; 2) Ben May Department for Cancer Research, University of Chicago, Chicago, IL.

792A
Building an interactome: Identifying novel Akirin-interacting factors. William Dawkins, Meghan Troutt, Aayushi Bhagwanji, Kate Majeski, Shelby Rogers, Scott J. Nowak. Department of Biology and Physics, Kennesaw State University, Kennesaw, GA 30144.

793B
Functions of the co-activator CBP in transcription and in control of early Drosophila embryo development. Mattias Mannervik. Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

794C
Pan-leg developmental regulators control pro-thoracic leg specific Scr expression. Christopher L. McCallough, Ece Eksi, Emily R. Wyskiel, Teresa V. Orenic. Biology, University of Illinois at Chicago, Chicago, IL.

795A
Post-translational modification of Vestigial modulates transcriptional response in developing wing cells. Virginia Pimmett¹, Hua Deng², Andrew Simmonds¹. 1) Cell Biology, University of Alberta, Edmonton, Alberta, Canada; 2) Molecular Biology & Genetics, Johns Hopkins University, Baltimore, Maryland, USA.

796B
Zelda sites activate expression and promote transcription factor binding in a strength-dependent manner. Zeba Wunderlich¹, Rahul Satija², Meghan D. Bragdon¹, Robert K. Bradley³, Angela H. DePace¹. 1) Systems Biology, Harvard Medical School, Boston, MA; 2) Broad Institute of MIT and Harvard, Cambridge, MA; 3) Fred Hutchinson Cancer Research Center, Seattle, WA.

797C
pΔTubHA4C, a new versatile vector for constitutive expression in Drosophila. Stephanie M. Arcia^1,2, Yan Zhang¹, Pedro Fernandez-Funez^1,3,4, Diego E. Rincon Limas^1,4. 1) Department of Neurology; 2) HHMI Science for Life Undergraduate Program; 3) Department of Neurosciences; 4) Genetics Institute and Center for Translational Research on Neurodegenerative Diseases; McKnight Brain Institute, University of Florida, Gainesville, FL.

798A
Allele-specific expression analysis in a large panel of intraspecific Drosophila melanogaster crosses. Daniel Campo¹, Justin Fear², Rita Graze², Peter Poon¹, Matt Salomon¹, John Tower¹, Lauren McIntyre², Sergey Nuzhdin¹. 1) University of Southern California, Los Angeles, CA; 2) University of Florida, Gainesville, FL.

799B
Identification of a tissue-specific transcription factor required for ecdysone production in the prothoracic gland of Drosophila. Erik Thomas Danielsen¹, Morten E. Møller¹, Rachel Harder², Michael B. O’Connor², Kim F. Rewtiz¹. 1) Department of Biology, Copenhagen University, Faculty of Science, Copenhagen, Denmark; 2) Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, USA.

800C
The molecular basis of enhancer-promoter choice. Jia Ling, Theresa Apoznanski, Stephen Small. Department of Biology, New York University, New York, NY.

801A
KDM5 interacts with heat shock factor (Hsf) to regulate cellular response to oxidative stress. Xingyin Liu, Christina Greer, Juile Secombe. Genetics, Albert Einstein Med College, Bronx, NY.

802B
Modeling Dorsal Feedback Interactions in the Developing Embryo. Michael D. O'Connell, Gregory T. Reeves. Department of Chemical & Biomolecular Engineering, NC State University, Raleigh, NC.

803C
Transcriptional Twister: characterizing the plasticity of a bipartite TCF binding motif. Hilary Cara Archbold¹, Ken M. Cadigan^1,2. 1) Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI; 2) Department of Molecular, Cellular and Developmental Biology , University of Michigan, Ann Arbor, MI.

804A
Mapping the cis-regulatory landscape of early embryonic development in Drosophila with hundreds of TFs. C. Blatti¹, M. Kazemian¹, S. Celniker², M. Brodsky³, S. Sinha¹. 1) U of Illinois, Urbana, IL; 2) LBL, Berkeley, CA; 3) U Mass Med School, Worcester, MA.

805B
Thermodynamic models predict quantitative expression levels driven by synthetic cis-regulatory modules in the Drosophila embryo. Daniel K. Bork^1,2, Adam S. Brown², Lily Li², Robert A. Drewell², Jacqueline M. Dresch¹. 1) Mathematics Department, Harvey Mudd College, Claremont, CA; 2) Biology Department, Harvey Mudd College, Claremont, CA.

806C
A synthetic biology approach to investigate conserved regulatory motifs in Drosophila melanogaster. Adam S. Brown¹, Daniel K. Bork^1,2, Lily Li¹, Jacqueline M. Dresch², Robert A. Drewell¹. 1) Biology Department, Harvey Mudd College, Claremont, CA; 2) Mathematics Department, Harvey Mudd College, Claremont, CA.

807A
Temporal coordination of two enhancers relies on the modulation of a common inductive signal. Lily S. Cheung¹, Alisa Fuchs², David S. A. Simakov³, Len M. Pismen³, Giorgos Pyrowolakis², Stanislav Y. Shvartsman¹. 1) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ; 2) Institute for Biology I, Albert-Ludwigs University of Freiburg, Germany; 3) Department of Chemical Engineering, Technion-Israel Institute of Technology, Israel.

808B
Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos. Stephen S. Gisselbrecht¹, Luis Barrera^1,2, Martin Porsch^1,3, Preston W. Estep⁴, Anastasia Vedenko¹, Anton Aboukhalil^1,5, Alexandre Palagi^1,6, Yongsok Kim⁷, Xianmin Zhu⁷, Brian Busser⁷, Alan M. Michelson⁷, Martha L. Bulyk^1,2,8,9. 1) Division of Genetics, Brigham & Women's Hospital, Boston, MA 02115; 2) Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138; 3) Institute of Computer Science, Martin Luther University of Halle-Wittenberg, 06099 Halle, Germany; 4) TeloMe, Inc., Waltham, MA 02451; 5) Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA 02139; 6) Bioengineering Department, Polytech Nice Sophia, University of Nice Sophia Antipolis, 06903, France; 7) Laboratory of Developmental Systems Biology, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892; 8) Dept. of Pathology, Brigham & Women's Hospital, Boston, MA 02115; 9) Harvard-MIT Division of Health Sciences and Technology (HST); Harvard Medical School, Boston, MA 02115.

809C
REDfly: The Regulatory Element Database for Drosophila. Marc S. Halfon^1,2,3,4, Jeffrey T. Palmer^2,5, Michael Simich^1,2, Benjamin Des Soye^1,2, Steven M. Gallo^2,5. 1) Department of Biochemistry, SUNY at Buffalo, Buffalo, NY; 2) NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, NY; 3) Department of Biological Sciences, SUNY at Buffalo, Buffalo, NY; 4) Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Buffalo, NY; 5) Center for Computational Research, SUNY at Buffalo, Buffalo, NY.

810A
Context-dependent requirements for DNA-binding by Runt in transcription activation and repression. Michael L. Higgins¹, Lisa Prazak², J. Peter Gergen³. 1) Graduate Program in Biochemistry and Structural Biology, Stony Brook University, Stony Brook, NY. 11794; 2) Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY 11794-5215; 3) Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794-5215.

811B
Decoding the transcriptional program of epidermal cell morphogenesis. Francois Payre^1,2, Delphine Menoret^1,2, Marc Santolini³, Isabelle Fernandes^1,2, Jennifer Zanet^1,2, Yvan Latapie^1,2, Pierre Ferrer^1,2, Herve Rouault³, Vincent Hakim³, Philippe Besse⁴, Ignacio Gonzales⁴, Rebecca Spokony⁵, Keven White⁵, Stein Aerts⁶, Serge Plaza^1,2. 1) Centre for Developmental Biology, University of Toulouse, Toulouse, France; 2) CNRS, UMR5547, Toulouse, France; 3) Laboratoire de Physique Statistique, ENS, Paris, France; 4) Institut de Mathematique, Toulouse, France; 5) Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA; 6) Laboratory of Computational Biology, KU Leuven, Belgium.

812C
Conserved structure of regulatory regions of the gap genes giant and Krüppel in Drosophila melanogaster and Rhodnius prolixus. Rolando V. Rivera-Pomar^1,2, Andrés Lavore¹. 1) Centro de Bioinvestigaciones, Univ Nacional del Noroeste de Buenos Aires, Pergamino, Buenos Aires, Argentina; 2) Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata. Florencio Varela, Argentina.

813A
Dissecting the cis-regulatory DNA that controls the POU-domain transcription factor genes, pdm-1 and pdm-2. Jermaine Ross^1,2, Thomas Brody¹, Ward F. Odenwald¹. 1) Neural Cell-Fate Determinants Section, NINDS, NIH, Bethesda, MD; 2) Brown University, Providence, RI.

814B
Spatial and temporal regulation of cell adhesion is mediated by discrete regulatory elements in the delilah locus. Adi Salzberg, Atalya Nachman, Naomi Halachmi, Nirit Egoz-Matia. Gen/Rappaport Fac Medicine, Technion Israel Ins Technology, Haifa, Israel.

815C
Quantitative modeling of a gene’s expression from its intergenic sequence. Md Abul Hassan Samee¹, Tara Lydiard-Martin², Angela DePace², Saurabh Sinha^1,3. 1) Dept of Comp Sci, Univ of Illinois, Urbana, IL; 2) Dept of Systems Biology, Harvard Medical School, Boston, MA; 3) Institute for Genomic Biology, Univ of Illinois, Urbana, IL.

816A
Transcription factor collaboration at the intersection of growth and patterning in the Hippo signaling pathway. Matthew Slattery¹, Roumen Voutev², Lijia Ma¹, Nicolas Negre¹, Kevin White¹, Richard Mann². 1) Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL; 2) Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY.

817B
A screen for developmental enhancers targeted by the Notch effector Su(H). Elizabeth K. Stroebele¹, Andrew Brittain¹, Xin Yuan¹, Seth Brown², Albert J. Erives¹. 1) Department of Biology, University of Iowa, Iowa City, IA; 2) Carver College of Medicine, University of Iowa, Iowa City, IA.

818C
Transcriptional regulation of the unpaired3 gene during Drosophila development. Yu-Chen Tsai, Hsin-Yi Huang. Dept Life Science, Tung-hai Univ, Taichung, Taiwan.

819A
Chromatin and Transcriptional Regulation in Drosophila Salivary Gland Development. Michael B. Wells, Deborah J. Andrew. Department of Cell Biology, Johns Hopkins University, Baltimore, MD.

820B
Regulatory architecture of the Drosophila IAB7b enhancer. Lauren N. Winkler¹, Jessica S. Kurata¹, Michael J. Nevarez¹, Lily Li¹, Jacqueline M. Dresch², Robert A. Drewell¹. 1) Biology Department, Harvey Mudd College, Claremont, CA; 2) Mathematics Department, Harvey Mudd College, Claremont, CA.

821C
Mechanisms Controlling repo Transcription. Jamie L. Wood, Bradley W. Jones. Dept. of Biology, University of Mississippi, Oxford, MS.

822A
Deciphering the cis-trans regulatory circuit mediating RTK/RAS signaling in visceral muscle founder cell specification. Yiyun Zhou^1,2, Emily Deutschman^1,2, Jean-Daniel Feuz⁵, Korneel Hens⁵, Bart Deplancke⁵, Marc S. Halfon^1,2,3,4. 1) Dept. of Biochemistry, SUNY-Buffalo, Buffalo, NY; 2) NYS Center of Excellence in Bioinformatics & Life Sciences; 3) Dept. of Biological Sciences, SUNY-Buffalo, Buffalo, NY; 4) Mollecular and Cellular Biology Depatment, Roswell Park Cancer Institute, Buffalo, NY; 5) Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

823B
Genetic dissection of the Mcp regulatory element from the BX-C. Mario A. Metzler¹, Daryl Gohl², Paul Schedl³, Martin Müller¹, Markus Affolter¹. 1) Biozentrum, Universität Basel, Basel, Switzerland; 2) Stanford University, Stanford, USA; 3) Princeton University, Princeton, USA.

824C
Expression of Epigenetic Reporters During Wound Closure in Drosophila larvae. Aimee E. Anderson, Sirisha Burra, Michael J. Galko. Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX.

825A
Goodness of fit: structural equation modeling methods to reconcile gene regulatory networks. Justin Fear^1,2, Daniel Campo³, Matthew Salomon³, Sergey Nuzhdin³, Lauren McIntyre². 1) Genetics & Genomics, University of Florida, Gainesville, FL; 2) Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL; 3) Section of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA.

826B
Beyond Codon Usage Bias: The Regulation of Translation Encoded in Synonymous Sites. David S. Lawrie¹, Dmitri A. Petrov². 1) Genetics, Stanford University, Stanford, CA; 2) Biology, Stanford University, Stanford, CA.

827C
Drosophila Myb represses retrotransposition and regulates DNA copy number. Juan Santana¹, Abby Long², Kealie Rogers², Stephen Butcher², Scott McDermontt², J. Robert Manak^1,2,3. 1) Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA; 2) Department of Biology, University of Iowa, Iowa City, IA; 3) Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA.

828A
Investigating context-dependent transcription factor binding in early Drosophila development. Jessica L. Stringham¹, Adam S. Brown², Robert A. Drewell², Jacqueline M. Dresch³. 1) Computer Science Department, Harvey Mudd College, Claremont, CA; 2) Biology Department, Harvey Mudd College, Claremont, CA; 3) Mathematics Department, Harvey Mudd College, Claremont, CA.

829B
An integrated image-to-mesh conversion and machine learning framework for gene expression pattern image analysis. Wenlu Zhang¹, Daming Feng¹, Andrey Chernikov¹, Nikos Chrisochoides¹, Sudhir Kumar^2,3, Shuiwang Ji¹. 1) Department of Computer Science, Old Dominion University, Norfolk, VA; 2) Center for Evolutionary Medicine and Informatic, The Biodesign Institute, Arizona State University, Tempe, AZ; 3) School of Life Sciences, Arizona State University, Tempe, AZ 85287.

830C
Groucho mediates a subset of Capicua repressor activities in Drosophila. Leiore Ajuria¹, Claudia Nieva¹, Marta Forés¹, Rona Grossman², Sergio González-Crespo¹, Ze'ev Paroush², Gerardo Jiménez^1,3. 1) IBMB-CSIC, Parc Científic de Barcelona, Barcelona, Spain; 2) Dept. of Developmental Biology and Cancer Research, IMRIC, The Hebrew Univ., Jerusalem, Israel; 3) ICREA, Barcelona, Spain.

831A
The Role of Dbcl11 in Drosophila Muscle Formation. Wiley Barton, Jennifer Elwell, Erica Baca, Richard Cripps. Biology, University of New Mexico, ALbuquerque, NM.

832B
The influence of hairpin RNA against lawc on the expression of overlapping lawc and Trf2 genes in D. melanogaster. Olga B. Simonova, Roman O. Cherezov, Julia E. Vorontsova, Ilya B. Mertsalov, Dina A. Kulikova. Genetics of Morphogenesis, Koltzov Institute of Developmental Biology, Moscow, Russian Federation.

833C
Transcription factors FTZ-F1 and Blimp-1 control the pupal development and eclosion timing in Drosophila. Abdelrahman Sayed Sultan¹, Hitoshi Ueda^1,2. 1) THE GRADUATE SCHOOL OF NATURAL SCIENCE AND TECHNOLOGY, OKAYAMA UNIVERSITY, OKAYAMA, JAPAN; 2) BIOLOGY DEPARTMENT, FACULTY OF SCIENCE, OKAYAMA UNIVERSITY, OKAYAMA, JAPAN.

834A
A novel role of transcriptional repressors on the targets of the Jak/Stat pathway, in larval hematopoiesis. Aditi Vyas, Soichi Tanda. Dept. of Biological Sciences, Ohio University, Athens, OH.

835B
The transcription elongation factor Spt5 interacts with Pleiohomeotic to mediate Polycomb Group Repression. Barbara H. Jennings, Robert Harvey. UCL Cancer Institute, University College London, London, United Kingdom.

RNA Biology

836C
Expression and evolution of lincRNAs in Drosophila pseudoobscura using RNA-Seq. Kevin G. Nyberg, Carlos A. Machado. Department of Biology University of Maryland, College Park, MD 20742.

837A
A tissue-specific microRNA prevents cellular reprogramming by two master regulator transcription factors. Anna Lyuksyutova, Mark Krasnow. Dept Biochem, Stanford Univ, Stanford, CA.

838B
Drosophila miRNA affinity purification for cell-type and tissue-specific miRNA profiling. Amanda Thomas¹, Weimin Xiao², Cristian Coarfa³, Pei-Jung Lee¹, Esther Jung¹, Gregg Roman^2,4, Preethi Gunaratne², Herman Dierick^1,5. 1) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 2) Department of Biology and Biochemistry, University of Houston, Houston, TX; 3) Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX; 4) Biology and Behavior Insitute, University of Houston, Houston, TX; 5) Department of Neuroscience, Baylor College of Medicine, Houston, TX.

839C
Visualisation of Ribosomal Subunits Interaction in Drosophila Cells. Akilu S. Abdullahi. Bioscience, University of Birmingham, Birmingham, Birmingham, W. Midlands, United Kingdom.

840A
Identification of directly targeted mRNA substrates of the NMD pathway. Alex Chapin, Mark Metzstein. Human Genetics, University of Utah, Salt Lake City, UT.

841B
Bicaudal-C controls the spatial and temporal expression of the nanos mRNA during Drosophila oogenesis. Chiara Gamberi^1,2, Paul Lasko². 1) Institut des Recherches Cliniques de Montreal, Montreal, PQ, Canada; 2) Department of Biology, McGill University Montreal Canada.

842C
Identification and analysis of RNAs associated with Sm proteins. Zhipeng Lu, Greg Matera. Biology, UNC at Chapel Hill, Chapel Hill, NC., NORTH CAROLINA.

843A
The NMD gene Smg5 is required for viability independent of NMD function. Jonathan Nelson¹, Dominique Foerster², Stefan Luschnig², Mark Metzstein¹. 1) Human Genetics, University of Utah, Salt Lake City, UT; 2) University of Zurich IMLS, Zurich, Switzerland.

844B
In vivo interactions of eIF4E in Drosophila cytoplasmic foci. Rolando V. Rivera-Pomar^1,2, Carla Layana^1,2, Paola Ferrero^1,2, Ezequiel Paulucci¹, Pablo Gutierrez¹. 1) Centro Reg Estudios Genomicos, Univ Nacional de La Plata, Florencio Varela, Buenos Aires, Argentina; 2) Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de Buenos Aires. Pergamino, Argentina.

845C
Exploring the role of the GW182 protein Gawky during Drosophila early embryogenesis. Jing Li, Andrew Simmonds. Dept. of Cell Biology, University of Alberta, Edmonton, Canada.

846A
Pervasive RNA localization in Drosophila ovaries. Helena Jambor, Pavel Mejstrik, Stephan Saalfeld, Pavel Tomancak. Max Planck Institute of Molecular Cell Biology and Genetics.

847B
How piRNA inheritance affects endogenous gene expression across generations. Alexandra A. Erwin, Michelle Wickersheim, Justin Blumenstiel. University of Kansas, Lawrence, KS.

848C
Mutations affecting piRNA system components alter snRNA levels in Drosophila ovaries. Alina P. Korbut, Sergey Lavrov, Vladimir Gvozdev. Institute of Molecular Genetics, Moscow, Russian Federation.

849A
Paramutation in Drosophila linked to emergence of a piRNA-producing locus. Stephane Ronsseray¹, Augustin de Vanssay¹, Catherine Hermant¹, Antoine Boivin¹, Laure Teysset¹, Valérie Delmarre¹, Anne-Laure Bougé², Christophe Antoniewski^2,1. 1) Biol du Developpement, CNRS/UMR7622, Paris, France; 2) Drosophila Genetics and Epigenetics, CNRS/URA2578, Institut Pasteur, Paris, France.

850B
The Role of Piwi in Transposon Silencing and Heterochromatin Formation. Kiri Ulmschneider, Monica Sentmanat, Sidney Wang, Sarah Elgin. Dept Biol, Washington University, St. Louis, MO.

851C
A Bioinformatic Analysis of Alternative Splicing Patterns in Metabolic Genes of Drosophila. Stacey J. Lytle¹, Alexis Nagengast². 1) Dept Biology; 2) Dept Biochemistry & Chemistry, Widener University, Chester, PA.

852A
Selective translational control refines cell-type specific responses to the steroid hormone ecdysone. Robert Ihry, Arash Bashirullah. Sch Pharmacy, Univ Wisconsin, Madison, Madison, WI.

853B
Mutations in a 5' region of the osk gene disrupt both Osk protein function and osk mRNA translational activation. Matt Kanke, Goheun Kim, Young-Hee Ryu, Paul M. Macdonald. Molecular Cell and Developmental Biology, University of Texas at Austin, Austin, TX.

854C
Role of Bruno phosphorylation in translational regulation of oskar. Goheun Kim¹, Keiji Sato², Akira Nakamura², Paul Macdonald¹. 1) Molecular Cell & Developmental Biology, University of Texas at Austin, Austin, TX; 2) Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Japan.

855A
Nutritional control of mRNA translation in Drosophila larvae. Sabarish Nagarajan, Savraj Grewal. Souther Alberta Cancer Research Institute, University of Calgary, Calgary, Alberta, Canada.

856B
The role of Bicoid Stability Factor in oskar regulation. Young Hee Ryu, Paul Macdonald. Molecular Cell & Developmental Biology, University of Texas at Austin, Austin, TX.

857C
Clk mRNA turnover de-noises circadian transcription and behavior in time and space. Sebastian Kadener¹, Lerner Immanuel¹, Bartok Osnat¹, Afik Shaked¹, Friedman Nir². 1) Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel; 2) Computer Sciences Department and Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.

Stem Cells

858A
A Sensitized Screen for Genes that Interact with Bag-of-marbles During Definitive Hematopoiesis. Erin A. T. Boyle, Dawn W. Hopkins, Robert A. Schulz. University of Notre Dame, Notre Dame, IN.

859B
Yorkie and Scalloped regulate availability of Serrate signaling cells required for crystal cell differentiation in the larval lymph gland. Gabriel B. Ferguson, Julian Martinez-Agosto. University of California, Los Angeles, Department Of Human Genetics. Los Angeles, CA.

860C
Loss of the nuclear lamina protein Otefin causes Checkpoint kinase 2-mediated death in female germline stem cells. Lacy J. Barton, Pamela K. Geyer. Dept Biochemistry, Univ Iowa, Iowa City, IA.

861A
Notch signaling controls Drosophila female germline stem cell competitiveness for niche occupancy. Tseng Cheng-Yuan^1,2, Hsu Hwei-Jan^1,2. 1) Institution of Cellular and Oragnismic Biology, Academia Sinica, Taipei, Taiwan; 2) Institution of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

862B
Bazooka Forms a Platform that Integrates Stem Cell Polarity and Cell Cycle Progression. Mayu Inaba^1,2, Yukiko Yamashita¹. 1) Center for stem cell biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI; 2) Department of Molecular Biology The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

863C
A Novel Interaction Between Stem Cell Factors FMRP and Zfrp8. William Tan, Tatyana Naryshkina, Neha Changela, Curtis Schauder, Ruth Steward. Waksman Institute, Rutgers University, Piscataway, NJ.

864A
pineapple eye, a putative Drosophila E3 ligase for FOXO, is required for stem cell self-renewal in three adult stem cell types, female GSC, male GSC and ISC. Yalan Xing, Manisha Thuparani, Irina Kurtz, Hannele Ruohola-Baker. Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, SEATTLE, WA.

865B
Systemic regulation of intestinal tissue homeostasis in Drosophila melanogaster. Arshad Ayyaz, Jason Karpac, Heinrich Jasper. Buck Institute for Research on Aging, Novato, CA.

866C
Transcriptome profiling of Drosophila melanogaster midgut cell populations by mRNA sequencing. Devanjali Dutta, Bruce Edgar. CELL GROWTH AND PROLIFERATION, ZMBH-DKFZ, HEIDELBERG, BADEN-WÜRTTEMBERG, Germany.

867A
Elucidating the tissue damage-sensing mechanism that maintains Drosophila midgut homeostasis. Julieta A. Maldera, Bruce A. Edgar. DKFZ-ZMBH Alliance, Heidelberg, Germany.

868B
APC loss-induced intestinal tumorigenesis in Drosophila: roles of Ras in Wnt signaling activation and tumor progression. Chen-Hui Wang, Rui Zhao, Pin Huang, Zhenghui Quan, Fu Yang, Na Xu, Rongwen Xi. NIBS, No. 7, Science Park Road, Zhongguancun Life Science Park,Beijing, China.

869C
Age-related stem cell de-regulation by ER stress in the Drosophila intestine. Lifen Wang¹, Hyung Don Ryoo², Heinrich Jasper¹. 1) Buck institute for research on aging.8001 Redwood Blvd, Novato, California. 94945, USA; 2) Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.

870A
Regulation of String during Drosophila intestinal stem cell proliferation. Jinyi Xiang, Bruce Edgar. Cell growth and proliferation, DKFZ-ZMBH Alliance, Heidelberg, Germany.

871B
SWI/SNF Chromatin Remodeling Complexes Regulate Stem Cell Asymmetric Division and Daughter Cell Fate Specification in Adult Drosophila Posterior Midgut. Xiankun Zeng¹, Xinhua Lin², Steven Hou¹. 1) The Mouse Cancer Gen Program, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702; 2) Key Laboratory of Stem Cell and Developmental Biology Institute of Zoology, Chinese Academy of Sciences, Beijing 1 Beichen West Road, Chaoyang District Beijing 100101, P.R.China.

872C
Drosophila activating transcription factor 3 non-autonomously regulating intestinal stem cell division and differentiation. Jun Zhou, Anna-Lisa Boettcher, Michael Boutros. Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany.

873A
Distinguishing progenitor cells from stem cells by dampening their responses to self-renewal transcription factors. Cheng-Yu Lee^1,2,3,4, Derek Janssens⁴, Hideyuki Komori¹. 1) Center for Stem Cell Biology, Life Sciences Institute; 2) Division of Molecular Medicine and Genetics, Department of Internal Medicine; 3) Department of Cell and Developmental Biology; 4) Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109.

874B
Selective functions for core promoter factors in neuroblast identity. Alexandre A. Neves, Robert N. Eisenman. Dept Basic Sci, Fred Hutchison Cancer Res Ctr, Seattle, WA.

875C
Hmgcr regulates spermatogonial dedifferentiation in Drosophila male germline. CY Ason Chiang¹, Yukiko Yamashita^1,2. 1) Cell and Developmental Biology, University of Michigan, Ann Arbor, MI; 2) Life Sciences Institute, University of Michigan, Ann Arbor, MI.

876A
Pvr is a receptor tyrosine kinase (RTK) that functions in Drosophila testis cyst stem cells. Kenneth Hammer, Kelli Johnson, Judy Leatherman. Biological Sciences, University of Northern Colorado, Greeley, CO.

877B
Investigating germline stem cell abscission delay as a mechanism for stem cell coordination in the testis niche. Kari Lenhart, Steve DiNardo. Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA.

878C
Ecdysone Regulation of Stem Cell Maintenance in the Drosophila Testis Niche. Yijie Li, Qing Ma, Erika Matunis*. Dept of Cell Biology, 725 N. Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205.

879A
A novel niche-specific aminopepetidase regulates dedifferentiation of progenitor germ cells in Drosophila testis. Cindy Lim, Xin Chen. Biology, Johns Hopkins University, Baltimore, MD.

880B
Impact of Wolbachia on the male stem cell niche biology. Stephanie M. Pontier¹, François Schweisguth^1,2. 1) Departement de developement, Institut Pasteur, Paris, France; 2) CNRS URA 2578.

881C
patched Increases Cellular Proliferation and Skews Neutral Drift Among Testis Stem Cells During Niche Competition. Marc Amoyel¹, Benjamin Simons², Erika Bach¹. 1) Biochemistry and Mol Pharmacology, New York University School of Medicine, New York, NY; 2) Department of Physics and The Wellcome Trust/Gurdon Institute, University of Cambridge, Cambridge UK.

882A
Diet controls Drosophila Follicle Stem Cell proliferation via Hedgehog sequestration and release. Tiffiney R. Hartman, Alana O'Reilly. Fox Chase Cancer Center, Philadelphia, PA.

883B
Multiple ovarian follicle stem cells reside in the germarium and contribute stochastically to follicle cell daughters. Amy Reilein¹, Ari Berg¹, David Melamed¹, Natania Field¹, Elisa Cimetta², Nina Tandon², Gordana Vunjak-Novakovic², Daniel Kalderon¹. 1) Biological Sciences; 2) Biomedical Engineering, Columbia University, New York, NY.

884C
Characterization of the Follicle Stem Cell Niche in Drosophila Ovary. Pankaj Sahai-Hernandez, Todd G. Nystul. Anatomy Dept., UCSF, San Francisco, CA.

885A
Identifying target genes for the stem cell transcription factor Zfh1 in the Drosophila testis. Qi Zheng^1,3, Stephen DiNardo^2,3. 1) Department of Biology, School of Arts and Sciences, Univ Pennsylvania, Philadelphia, PA; 2) Dept Cell & Developmental Biol, Perelman Sch Med, Univ Pennsylvania, Philadelphia, PA; 3) Penn Institute for Regenerative Medicine, Philadelphia, PA.

Systems Biology

886B
Mechanism of Silver Nanoparticles Action on Insect Pigmentation Reveals Intervention of Copper Homeostasis. Atanu Duttaroy¹, Najealicka Armstrong¹, Malaisamy Ramamoorthy², Delina Lyon², Kimberly Jones². 1) Dept Biol, Howard Univ, Washington, DC; 2) Department of Civil and Environmental Engineering, Howard University, Washington, DC.

887C
Constructing a Synthetic Gene Network to Model and Understand Signaling Interactions in Drosophila melanogaster. Ashley Jermusyk, Gregory Reeves. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC.

888A
Mining ChIP data for evidence of mechanisms underlying transcription factor DNA-occupancy. Qiong Cheng¹, Majid Kazemian¹, Hannah Pham², Charles Blatti¹, Michael Brodsky², Saurabh Sinha¹. 1) Department of Computer Science, UIUC, IL 61801; 2) Department of Molecular Medicine, University of Massachusetts Medical School, MA 01655.

889B
Direct Quantification of Transcriptional Regulation at an Endogenous Gene Locus. Heng Xu¹, Anna Sokac¹, Ido Golding^1,2. 1) Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX; 2) Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL.

Techniques and Functional Genomics

890C
Phylogenetic footprinting and comparative analysis of related cis-regulatory modules reveals structural constraints on enhancer evolution and function. Thomas Brody¹, Alexander Kuzin¹, Mukta Kundu¹, Jermaine Ross¹, Amar Yavatkar², Ward F. Odenwald¹. 1) Neural Cell-Fate Determinants Section; 2) Information Technology Program, NINDS/NIH, Bethesda, MD.

891A
GeneSeer: A Flexible, Easy-to-Use Tool to Aid Drug Discovery by Exploring Evolutionary Relationships Between Genes Across Genomes. Douglas D. Fenger, Matthew Shaw, Philip Cheung, Tim Tully. Bioinformatics Dept, Dart NeuroScience, San Diego, CA.

892B
myFX: Turn-key software for laboratory desktops that analyzes spatial patterns of gene expression in Drosophila embryos. Sudhir Kumar^1,2, Ivan Montiel¹, Qian Sun^1,3, Michael McCutchan¹, Bremen Braun¹, Adam Orr¹, Stuart Newfeld^1,2, Jieping Ye^1,3. 1) Center for Evolutionary Medicine and Informatics, Arizona State Univ, Tempe, AZ; 2) School of Life Sciences, Arizona State Univ, Tempe, AZ; 3) School of Computing, Informatics, and Decision Systems Engineering, Arizona State Univ, Tempe, AZ.

893C
Sinbad Fly: A resource for functional variant discovery in Drosophila melanogaster. Kjong-Van Lehmann, Paul Marjoram, Ting Chen. University of Southern California, Los Angeles, CA.

894A
Advances in the FlyExpress Platform Facilitate the Integration of Gene Expression Spatial Patterns with Associated Regulatory Sequence. Michael E. McCutchan¹, Sudhir Kumar^1,2. 1) Center for Evolutionary Medicine and Informatics, Biodesign Institute, Arizona State Univ, Tempe, AZ; 2) School of Life Sciences, Arizona State Univ, Tempe, AZ.

895B
Recent advances in NCBI's Eukaryotic Genome Annotation Pipeline and expansion to process RNA-seq data. Terence D. Murphy, Alexander Souvorov, Francoise Thibaud-Nissen, Eyal Mozes, Wratko Hlavina, Eric Engelson, Olga Ermolaeva, Alex Astashyn, Craig Wallin, David Managadze, Kim Pruitt, Paul Kitts, Michael DiCuccio. NCBI, NIH, Bethesda, MD.

896C
Impact of P278A mutation conferring Breast Cancer susceptibility in the p53 DNA-Binding Core Domain interacting partners. Yeguvapalli Suneetha, Chitrala Kumaraswamy Naidu. Department of zoology, Sri venkateswara University, Tirupati, India.

897A
Leveraging a knowledge base of Drosophila cis-regulatory modules for regulatory element discovery in diverged insect species. Kushal Suryamohan¹, Majid Kazemian², Jia-Yu Chen², Yinan Zhang², Marc Halfon^1,3,4, Saurabh Sinha². 1) Department of Biochemistry and Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo; 2) Department of Computer Science, University of Illinois Urbana-Champaign, IL; 3) Department of Biological Sciences, State University of New York at Buffalo; 4) Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Buffalo, NY.

898B
Automated Annotation of Developmental Stages of Drosophila Embryos by Image Analysis. Jieping Ye^1,2, Lei Yuan^1,2, Qian Sun^1,2, Cheng Pan^1,2, Michael McCutchan¹, Stuart Newfeld³, Sudhir Kumar^1,3. 1) Center for Evolutionary Medicine and Informatics, Biodesign Institute, Arizona State University, Tempe, AZ; 2) Computer Science and Engineering, Arizona State University, Tempe, AZ; 3) School of Life Sciences, Arizona State University, Tempe, AZ.

899C
MiMIC-TIFF: A Method for Making Gene-specific Gal4 lines from MiMIC Insertions into Coding Introns. Fengqiu Diao¹, Feici Diao¹, Sarah Naylor¹, Holly Ironfield², Matthias Landgraf², Benjamin White¹. 1) Laboratory of Molecular Biology, NIMH, NIH, Bethesda, MD 20892; 2) University of Cambridge, Dept. of Zoology, Cambridge, UK.

900A
Transposon-based forward and reverse genetics in Anopheles mosquitoes. David A. O'Brochta^1,2, Kristina L. Pilitt¹, Robert A. Harrell, II¹, Channa Aluvihare¹, Robert T. Alford¹. 1) Institute for Bioscience and Biotechnology Research, University of Maryland, College Park, MD; 2) Department of Entomology, University of Maryland, College Park, MD.

901B
Tools to Facilitate Circuit-Mapping Using the Split Gal4 System. William C. Shropshire¹, Haojiang Luan^1,2, Benjamin White¹. 1) Section on Neural Function, NIH, NIMH, Bethesda, MD; 2) Janelia Farm Research Campus, Ashburn, VA.

902C
Developing a quantitative, cellular resolution morphology and gene expression atlas for Drosophila embryogenesis: towards a digital 'Campos-Ortega and Hartenstein’. Soile V. E. Keränen¹, Jonathan T. Barron², Pablo Arbelaez², Jitendra Malik², Mark D. Biggin¹, David W. Knowles¹. 1) Life Sci Div, Lawrence Berkeley Natl Lab, Berkeley, CA; 2) Electrical Engineering and Computer Science, UC Berkeley, Berkeley, CA.

903A
Ultrastructural analysis of Drosophila melanogaster using Helium Ion Microscopy. Dennis R. LaJeunesse^1,3, Adam Boseman¹, Kyle Nowlin¹, Jijin Yang². 1) Dept Nanoscience, Joint School of Nanoscience and Nanoengineering, Greensboro, NC; 2) Carl Zeiss NTS, LLC, Peabody, Massachusetts; 3) Department of Biology, UNCG, Greensboro, NC 27402.

904B
A high-throughput template for optimizing Drosophila organ culture with response surface methods. Jeremiah J. Zartman^1,2, Simon Restrepo², Konrad Basler². 1) Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN; 2) Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

905C
Accounting for systematic error in RNA-seq based analysis of allele-specific expression. Rita M. Graze^1,4, Luis G. Léon-Novelo², George Casella (posthumous)^3,4, Justin M. Fear^1,4, Lauren M. McIntyre^1,4. 1) MGM, UF, Gainesville, FL; 2) Mathematics, UL-LFT, Lafayette , LA; 3) Statistics, UF, Gainesville, FL; 4) Genetics Institute, UF, Gainesville, FL.

906A
Forward genetic screen to identify genes functioning in winner cells during cell competition. Chang Hyun Lee, Gerard Rimesso, Nicholas Baker. Genetics, Albert Einstein College of Medicine, Bronx, NY.

907B
Global analysis of the Dorsal-ventral patterning regulatory network in the wasp Nasonia vitripennis. Jeremy A. Lynch^1,2, Thomas Buchta², Orhan Özüak², Siegfried Roth². 1) Molecular, Cell, and Developmental Biology, University of Illinois at Chicago, Chicago, IL; 2) Institute for Developmental Biology, University of Cologne, Cologne, Germany.

908C
Vienna Tiles (VT) GAL4 driver lines: New resources at the Vienna Drosophila RNAi Center (VDRC). Lisa A. Meadows¹, Dickson Group², Stark Group², VDRC Team¹, Alexander Stark², Barry Dickson². 1) Vienna Drosophila RNAi Center, Campus Science Support Facilities, Vienna, Austria; 2) IMP - Research Institute of Molecular Pathology, Vienna, Austria.

909A
dmFUCCI - a novel tool for studying cell proliferation in complex tissues. Norman Zielke, Jerome Korzelius, Monique van Straaten, Hanna Reuter, Katharina Bender, Gregor Schuhknecht, Juliette Pouch, Bruce Edgar. DKFZ/ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.

910B
A cytosolic Superoxide dismutase mutant allele and it’s metabolism: Investigating the metabolic profile of a mutant fly using Liquid Chromatography - Mass Spectrometry. Jose M. Knee¹, Teresa Rzezniczak¹, Kevin Guo², Thomas Merritt¹. 1) Chemistry & Biochemistry Department, Laurentian University, Sudbury, Ontario, Canada; 2) Bruker Daltonics Inc., Billerica, MA.

Neural Development

911C
CG3533 plays an important role in axonal targeting and circuit formation in the olfactory system of Drosophila. Arzu Çelik¹, Thomas Hummel², Mustafa Talay¹, Kaan Apaydin¹, Selen Zülbahar¹. 1) Dept Mol Bio and Genetics, Bogazici Univ, Istanbul, Turkey; 2) Dept Neurobiology, Univ Vienna, Vienna, Austria.

912A
Establishing new roles of Daughterless in the Drosophila melanogaster central nervous system. Mitchell D'Rozario¹, Tina Hu¹, Mohammad Nayal¹, Kaveesh Kutty¹, Daniel Marenda^1,2. 1) Department of Biology, Drexel University, Philadelphia, PA; 2) Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA.

913B
Cross-talk between cellular identity specification and axon growth cone guidance in the developing Drosophila embryonic nerve cord. Mary Ann Manavalan, Gaziova Ivana, Bhat Krishna M. Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX.

914C
Transcriptome analysis of unfulfilled-dependent gene expression in the mushroom body neurons. Janos Molnar, Karen Bates, Steven Robinow. Biology, University of Hawaii, Honolulu, HI.

915A
Cell death influences structural reorganization of the larval nervous system during metamorphosis. Soumya Banerjee, Matthew Siefert, Marcus Toral, Joyce Fernands. Zoology, Miami Univ, Oxford, OH.

916B
Characterization of developmental expression pattern and identification of associated genes in Gal4 enhancer traps. Christopher R. Dunne, Devin T. Gordon-Hamm, Elizabeth C. Marin. Biology, Bucknell University, Lewisburg, PA.

917C
Expression of the Calcium-independent Receptor of α-Latrotoxin (Cirl) in developing Drosophila melanogaster. Steve M. Saylor, Mark FA VanBerkum. Biological Sciences, Wayne State University, Detroit, MI.

918A
Manipulation of dHb9-expressing Motor Neurons Results in Eclosion Defects. Marcus A. Toral, Soumya Banerjee, David Conway, Joyce Fernandes. Miami University, Oxford, OH.

919B
The Novel Zinc-BED transcription factor, bedwarfed, is essential for dendritic growth and scaling. Eswar P. R. Iyer, Srividya C. Iyer, Luis Sullivan, Yukting Lau, Shaurya Prakash, Vihitha Thota, Farheen Shaikh, Daniel N. Cox. School of Systems Biology, Krasnow Institute for Advanced Study, George Mason Univ, Fairfax, VA.

920C
Ubuiquitin proteasome system regulates dendrite pruning of Drosophila sensory neuron. Tzu Lin, Yi-Ping Wu, Sih-Hua Chen, Hsiu-Hsiang Lee. Institute of Molecular Medicine, College of Medicine, National Taiwan University.

921A
Analysis of Dendrite Patterning Dynamics in Novel Self-Avoidance Mutant. Marvin Nayan, Jay Parrish. Dept. of Biology, University of Washington, Seattle, WA.

922B
Nejire, a CBP/p300 family transcription factor, regulates dendritic development by modulating the localization of the Krüppel-like transcription factor Dar1 in Drosophila da neurons. Myurajan Rubaharan, Srividya C. Iyer, Eswar P. R. Iyer, Daniel N. Cox. School of Systems Biol., Krasnow Inst. Adv. Study, George Mason University, Fairfax, VA.

923C
Survival of glia in optic lamina is maintained by EGFR signal provided by photoreceptors in adult Drosophila visual system. Yuan-Ming Lee^1,2, Y. Henry Sun^1,2. 1) N415, Inst Molecular Biology, Taipei, Taiwan; 2) Institute of Genomic Science, National Yang-Ming University, Taipei, Taiwan.

924A
Basigin maintains glial wrapping of axons. Lindsay Petley-Ragan. Zoology, University of British Columbia, Vancouver, BC, BC, Canada.

925B
Manipulating the remodeling of glial ensheathment of peripheral nerves during metamorphosis. Matthew Siefert, Soumya Banerjee, Sayantan Mitra, Jack Wilber, Joyce Fernandes. Zoology, Miami University, Oxford, OH.

926C
Regulating neuronal composition in the Drosophila mushroom body through hormonal extrinsic cues. Daniel I. Fritz, Abigail Lubin, Alper Dincer, Jaspinder Kanwal, Elizabeth Marin. Biology, Bucknell University, Lewisburg, PA.

927A
A screen for suppressors of unfulfilled reveals novel roles for genes in Drosophila mushroom body development. Karen E. Bates¹, Carl Sung², Joshua Meldon¹, Liam Hilson¹, Steven Robinow¹. 1) University of Hawaii Department of Biology 2450 Campus Road Honolulu, HI 96822; 2) University of Chaminade Department of Natural Sciences and Mathematics Honolulu, HI 96822.

928B
Regulation of dendrite morphogenesis by Nanos and Pumilio. Balpreet Bhogal, Elizabeth Gavis. Department of Molecular Biology, Princeton University, Princeton, NJ.

929C
Regulation of metamorphic neuronal remodeling by alan shepard (shep).. Dahong Chen, Randall Hewes. Department of Biology, University of Oklahoma, Norman, OK.

930A
Drosophila Tempura, a putative protein prenyltransferase, regulate synaptic growth and synaptic transmission. Kuchuan Chen¹, Wu-Lin Charng¹, Shinya Yamamoto¹, Nele Haelterman¹, Guang Lin^2,4, Hugo Bellen^1,2,3,4. 1) Program in Developmental Biology; 2) Dept of Molecular and Human Genetics; 3) Dept of Neuroscience; 4) Howard Hughes Medical Institute; Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, TX.

931B
PPR-proteins, which are implicated in the neurodegenerative disease Leigh Syndrome, reveal a role for mitochondria in attenuating BMP-signaling. Nele Haelterman¹, Manish Jaiswal², Berrak Ugur¹, Hector Sandoval², Ke Zhang³, Taraka Donti², Brett Graham², Vafa Bayat¹, Shinya Yamamoto^1,2, Hugo Bellen^1,2,3,4. 1) Program in Developmental Biology; 2) Department of Molecular and Human Genetics; 3) Structural and Computational Biology & Molecular Biophysics Graduate Program; 4) Howard Hughes Medical Institute, Neurological Research Institute, Baylor College of Medicine, Houston, TX 77030.

932C
Adult brain compartment formation requires proper scaffolding by secondary neuronal lineages. Jennifer K. Lovick, Volker Hartenstein. MCDB, UCLA, Los Angeles, CA.

933A
A Drosophila Cobblestone Lissencephaly model reveals Dystroglycan is buffered by microRNA-310s via its alternative 3’UTR. Halyna R. Shcherbata, Andriy S. Yatsenko, April K. Marrone. MPRG of Gene Expression and Signaling, Max Planck Institute, Goettingen, Germany.

934B
Role of cell death in the development of the adult Drosophila optic lobe during metamorphosis. Hidenobu Tsujimura¹, Tatsuya Sudo¹, Yusuke Hara^1,2, Yu Togane¹, Hiromi Akagawa^1,2, Ayano Ishitsuka¹, Masashi Iwamura¹, Ryo Iizuka¹, Ayaka Tsutsumi¹. 1) Dept Dev Biol, Tokyo Univ Agric & Tech, Fuchu-si, Tokyo, Japan; 2) Dept Bio Pro Sci, Tokyo Univ of Agric & Tech, Fuchu-si, Tokyo, Japan.

935C
Regulation of Axonal Branch Refinement by EGF-Receptor Signaling. Marlen Zschaetzsch, Bassem Hassan. VIB, Leuven, Belgium.

936A
Sexual identity affects the development and mature function of a defined neural circuit in Drosophila melanogaster. Parag Bhatt, Selma Advagic, Harsha Swamy. Pharmcological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO.

937B
The transcriptional code of adult motoneuron identity in Drosophila. Jonathan Enriquez¹, Myungin Baek², Richard Mann¹. 1) Department of Biochemistry and Molecular Biophysic, Columbia University Medical Center , New York, NY; 2) NYU School of Medicine Neuroscience Program 522 First Avenue SML504 New York, NY 10016.

938C
Antp regulates segment-specific survival and morphology in the postembryonic ventral nervous system. Ginna E. Freehling, Danielle R. Alaimo, Kirstin T. Rudd, Anthony R. Cillo, Elizabeth C. Marin. Bucknell University, Lewisburg, PA.

939A
Actin associates with bHLH proneural proteins in nucleus and positively regulates neural precursor gene expression. Yun-Ling Hsiao^1,2, Yu-Ju Chen^1,2, Hsiao-Fong Yeh², Haiwei Pi^1,2. 1) Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan; 2) Department of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan.

940B
Thinking hard for Scarecrow, the NKX2.1 homolog of Drosophila. Crystal L. Maki, Albert J. Erives. Dept. of Biology, University of Iowa.

941C
Salt Inducible Kinases in Drosophila Neural Development. Bahar H. Sahin¹, Sercan Sayin^1,2, Nic Tapon³, Arzu Celik¹. 1) Molekuler Biyoloji ve Genetik Bolumu, Bogazici Universitesi, Istanbul, Turkey; 2) Max Planck Institute of Neurobiology, Munchen, Germany; 3) London Research Institute, Lincoln’s Inn Fields Laboratories, London, UK.

942A
The larval-to-pupal onset of let-7-Complex microRNAs regulates chinmo to specify neuronal temporal identity. Nicholas S. Sokol, Yen-Chi Wu. Dept Biol, Indiana Univ, Bloomington, IN.

943B
Mitosis in neurons: Roughex and APC/C maintain cell cycle exit to prevent cytokinetic and axonal defects in Drosophila photoreceptor neurons. Nick Baker¹, Robert Ruggiero¹, Abhijit Kale¹, Barbara Thomas². 1) Genetics, Albert Einstein College of Medicine, Bronx, NY; 2) Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD.

944C
Characterization of neuronal death and degeneration upon cell cycle re-entry in rux and APC/C mutants. Adriana De La Garza, Nicholas E. Baker. Albert Einstein College of Medicine, Bronx, NY.

945A
Function of JAK/STAT and Hippo signaling pathways on Drosophila mushroom body neuroblast maintenance and cell proliferation. Lijuan Du¹, Jian Wang^1,2. 1) Molecular and Cell Biology Program, University of Maryland, College Park, MD; 2) Entomology Department, University of Maryland, College Park, MD.

946B
Muscle associated Drosophila adducin regulates Drosophila larval neuromuscular junction (NMJ) development and the localization of Draper to the synapse. Mannan Wang¹, Simon Wang², Charles Krieger¹, Nicholas Harden², Wade Parkhouse¹. 1) Department of Biomedical Physiology and Kinesiology, SFU, Burnaby, BC, Canada; 2) Department of Molecular Biology and Biochemistry, SFU, Burnaby, BC, Canada.

947C
Variation in larval locomotion and NMJ among melanogaster sibling species. Emma Yang, Mirela Belu, Claudia Mizutani. Case Western Reserve University, Cleveland, OH.

948A
Nemo is a core proneural target gene and a feedback inhibitor of Atonal in the Drosophila eye. Vilaiwan Fernandes¹, Lorena Braid^1,2, Esther Verheyen¹. 1) Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada; 2) Defence Research and Development Canada - Suffield, Biotechnology Section, Medicine Hat, Alberta, T1A 8K6, Canada.

949B
The transcription factor Escargot is involved in neuronal differentiation. Anne Ramat, Michel Gho. Laboratory of Developmental Biology CNRS/UPMC, Paris, France.

950C
Sanpodo controls sensory organ precursor fate by regulating Notch trafficking and interaction with gamma-secretase. Fabrice Roegiers¹, Alok Upadhyay¹, Vasundhara Kandachar¹, Diana Zitserman Zitserman¹, Xin Tong Tong^1,2. 1) Fox Chase Cancer Ctr, Philadelphia, PA; 2) Dept. of Molecular & Integrative Physiology University of Michigan Medical School.

951A
Synaptic localization of iGluR complexes is regulated by the modulation of Neto extracellular domain. Young-Jun Kim, Mihaela Serpe. NICHD, National Institute of Health, Bethesda, MD.

952B
Two Neto isoforms are required for proper synapse assembly at the Drosophila NMJ. Cathy I. Ramos, Oghomwen Igiesuorobo, Mihaela Serpe. NICHD, NIH, Bethesda, MD.

953C
BMP signaling is required for synapse assembly at the Drosophila neuromuscular junction. Mikolaj J. Sulkowski¹, Young-Jun Kim¹, Bing Zhang², Mihaela Serpe¹. 1) Program in Cellular Regulation and Metabolism, NICHD, NIH, Bethesda, MD, USA, 20892; 2) Department of Zoology, University of Oklahoma, Norman, OK, USA, 73019.

954A
Pk17e regulates Drosophila NMJ synapse development and function. Guoli Zhao¹, Li Du², Qifu Wang¹, Yongqing Zhang¹. 1) Institute of Genetics and Developmental Biology, Beijing, Beijing 100101, China; 2) College of Life Science, Hubei University, Wuhan, Hubei 430062, China.

Educational Initiatives

955B
Nora virus Transmission in Drosophila melanogaster: An Investigation to Teach Virulence and Pathogenic Prophylaxis to Biology Students. Darby J. Carlson¹, Wayland Weatherred^1,2, Kimberly A. Carlson¹. 1) Biology Department, University of Nebraska at Kearney, Kearney, NE; 2) Aspen High School, Glenwood Springs, CO.

956C
The Genomics Education Partnership (GEP): Bringing Genomics Research into Undergraduate Classrooms. SCR Elgin¹, M. Burg², J. DiAngelo³, A. Haberman⁴, C. Jones⁵, L. Kadlec⁶, SCS Key⁷, J. Leatherman⁸, GP McNeil⁹, H. Mistry¹⁰, A. Nagengast¹⁰, DW Paetkau¹¹, S. Parrish¹², L. Reed¹³, S. Schroeder¹⁴, S. Smith¹⁵, M. Wawersik¹⁶, L. Zhou¹⁷, D. Lopatto¹⁸. 1) Washington U MO; 2) Grand Valley St MI; 3) Hofstra NY; 4) Oberlin OH; 5) Moravian PA; 6) Wilkes PA; 7) NC Central NC; 8) Northern Colorado CO; 9) York/CUNY NY; 10) Widener PA; 11) St Mary's IN; 12) McDaniel MD; 13) Alabama-Tuscaloosa AL; 14) Webster MO; 15) Arcadia PA; 16) William & Mary VA; 17) U Pittsburgh PA; 18) Grirnnell IA.

957A
Learning Outcomes in a Required Biology Majors Genetics Course Using Two Different Pedagogies: Modified Team Based Learning Compared to Traditional Lecture. Susan R. Halsell, Timothy A. Bloss, Kimberly H. Slekar. Dept Biol, James Madison Univ, Harrisonburg, VA.

958B
An Investigative Genetics Lab Course Using Drosophila Neurologic Mutants. Pat C. Lord, Cole Crowson, Erik C. Johnson. Dept Biol, Wake Forest Univ, Winston-Salem, NC.

959C
Annotation of Fosmid 60 of Drosophila erecta and of DMAC 47 of Drosophila mojavensis as control sequences in the comparative genomic analysis of the Drosophila dot chromosome. Carolina Marques dos Santos Viera, Tiara Tirasawasdichai, Susan Parrish. Biology Department, McDaniel College, Westminster, MD 21157.

960A
An Interdisciplinary Approach to Molecular Bioscience Content in the Undergraduate Curriculum. Alexis Nagengast^1,3, Shirley Fischer-Drowos^1,3, Robert W. Morris^1,2, Hemlata Mistry^1,2. 1) Dept Biochemistry; 2) Dept Biology; 3) Dept Chemistry, Widener University, Chester, PA.

961B
A comparative genomic analysis of the Drosophila dot chromosome. William G. Neutzling, Melissa Jones, Genomics Education Partnership. Biology, McDaniel College, Westminster, MD.

962C
The blog “Ciber-Genética” is a resource for teaching and learning. Rosario Rodriguez-Arnaiz, Lucero León Rangel, Isaac Reyes Martínez, Jovana Jasso Martínez, América Nitxin Castañeda Sortibrán. Dept Cellular Biol, Sci Fac, UNAM, Mexico, DF, D.F., Mexico.

963A
Mapping and cloning recessive wing mutations in an undergraduate course. Eric P. Spana, Samuel C. Arnold, S. Canon Brodar, Emily Chang, Karen Y. He, Andrew Hollis, Yanjun Anna Liu, David K. Lung, Sasha McEwan, Uchenna C. Osuji, Ann Prybylowski, Clara Starkweather, Diana L. Xie, Qingyun Li. Department of Biology, Duke University, Durham, NC.

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